骨促结缔组织增生性纤维瘤的临床病理观察

目的：了解骨促结缔组织增生性纤维瘤的临床病理。方法：收集骨促结缔组织增生性纤维瘤1例和6例腹壁外韧带样纤维瘤病的临床资料。手术切除组织HE染色光镜观察。涂胶切片做Vimentin,Desmin,NF,S100蛋白的单克隆标记。结果：骨促结缔组织增生性纤维瘤的组织学改变和免疫组织化学标记与腹壁外韧带样纤维瘤病相似,临床症状和影像学改变与骨样骨瘤相似。结论：骨促结缔组织增生性纤维瘤易发生于青年男性,病理才能将其确诊,有复发的可能。     

Long-term outcome prediction by clinicopathological risk classification algorithms in node-negative breast cancer--comparison between Adjuvant!, St Gallen, and a novel risk algorithm used in the prospective randomized Node-Negative-Breast Cancer-3 (NNBC-3) trial

BACKGROUND: Defining risk categories in breast cancer is of considerable clinical significance. We have developed a novel risk classification algorithm and compared its prognostic utility to the Web-based tool Adjuvant! and to the St Gallen risk classification. PATIENTS AND METHODS: After a median follow-up of 10 years, we retrospectively analyzed 410 consecutive node-negative breast cancer patients who had not received adjuvant systemic therapy. High risk was defined by any of the following criteria: (i) age <35 years, (ii) grade 3, (iii) human epithelial growth factor receptor-2 positivity, (iv) vascular invasion, (v) progesterone receptor negativity, (vi) grade 2 tumors >2 cm. All patients were also characterized using Adjuvant! and the St Gallen 2007 risk categories. We analyzed disease-free survival (DFS) and overall survival (OS). RESULTS: The Node-Negative-Breast Cancer-3 (NNBC-3) algorithm enlarged the low-risk group to 37% as compared with Adjuvant! (17%) and St Gallen (18%), respectively. In multivariate analysis, both Adjuvant! [P = 0.027, hazard ratio (HR) 3.81, 96% confidence interval (CI) 1.16-12.47] and the NNBC-3 risk classification (P = 0.049, HR 1.95, 95% CI 1.00-3.81) significantly predicted OS, but only the NNBC-3 algorithm retained its prognostic significance in multivariate analysis for DFS (P < 0.0005). CONCLUSION: The novel NNBC-3 risk algorithm is the only clinicopathological risk classification algorithm significantly predicting DFS as well as OS.     

中药灯盏花中两个新的苷类化合物结构的研究

从中药灯盏花（Erigeron breviscapus)全草乙醇提取物中分离得到了二个新化合物灯盏花苷I和Ⅱ,应用现代波谱技术和化学方法确定了它们的化学结构。     

MR 平面回波快速成像技术应用研究

目的 结合不同类型ＥＰＩ成像技术的特点,研究不同对比度ＥＰＩ的颅脑疾病诊断中的临床应用价值。方法 各类颅脑疾病患者１３６例所有病例行常规的ＭＲ扫描及ＥＰＩ。结果 ①应用ＥＰＩ扩散加像（及ＡＤＣ图）与ＥＰＩ－Ｔ２加权像对超急性期脑中风的诊断灵敏性与特异性均为１００％,联合ＴＳＥ－Ｔ２ＷＩ与Ｔ１ＷＩ的灵敏性与特异性分别为０％与４２．８５％（ｘ＾２＝１４．０８,Ｐ〉０．０１）。②常规ＭＲＩ上胆脂瘤表现为     

MR 平面回波快速成像技术与常规MRI 的比较研究

目的 阐明了ＥＰＩ的技术特点,与常规ＭＲＩ进行比较研究。讨论产生各种对比度ＥＰＩ成像的序列设计原理。探讨不同类型ＥＰＩ在颅脑疾病诊断中的价值与限度。方法 对颅脑疾病１２５例进行常规的ＭＲ扫描及ＥＰＩ成像。结果民①成像速度：ＥＰＩ成像速度达到３０毫秒／层。可去除运动伪影。②ＥＰＩ－ＴＷＩ、ＥＰＩｉｒｍ对病灶的显示率低于ＴＳＥ－Ｔ２ＷＩ、ＴＳＥ－反转恢复序列与双回波序列。对颅内病灶的显示率分别为７２．     

颞下颌关节上腔扩张术治疗内紊乱致张口受限的临床研究

】     

Clinical and laboratory studies of levamisole in patients with rheumatoid arthritis.

Two studies with levamisole in rheumatoid arthritis are reported. In the first study of 30 patients levamisole was superior to placebo in terms of pain relief, reduction in articular tenderness, duration of morning stiffness, erythrocyte sedimentation rate (ESR), and radioisotope uptake in knee and wrist joints. There were no consistent differences in lymphocyte function, immunoglobin or complement concentration, or polymorphonuclear granulocytic function. In the second study forty patients were commenced on treatment with either gold or levamisole. At the end of one year there were significant improvements with both regimens in pain score, joint tenderness and ESR. The patients on levamisole showed significant improvement of duration of morning stiffness, while the patients on gold showed significant improvement of rheumatoid factor titre and left hand grip, but there were no significant differences between the two regimens.     

骨髓铁染色对缺铁性贫血与慢性疾病性贫血的鉴别诊断价值

目的:探讨骨髓铁染对缺铁性贫血和慢性疾病性贫血的鉴别诊断价值。方法:选取缺铁性贫血、慢性疾病性贫血的骨髓片行染色检查,显微镜下检测细胞内外铁。结果:缺铁性贫血和慢性疾病性贫血患者细胞内铁明显减少;缺铁性贫血患者细胞外铁明显减少,慢性疾病贫血患者胞外铁明显增加(P<0.001)。结论:骨髓铁染色是鉴别诊断缺铁性血和慢性疾病性贫血简单易行的方法。     

犬PRF复合BMSCs修复拔牙窝颊侧骨壁缺损的实验研究

目的:评价富血小板纤维蛋白(PRF)构建的组织工程骨,在颊侧骨壁缺损修复中的成骨作用。方法:体外将PRF作用于比格犬的骨髓间充质干细胞(BMSCs),第21天测定钙结节量;4、7、11 d时采用实时定量PCR法检测成骨相关基因。9只成年比格犬拔除上颌左右两侧的侧切牙,构建颊侧骨壁缺损的拔牙位点,并随机分为血凝块组、PRF组和组织工程骨组,在手术后即刻、6周及12周时评价各组的颊侧骨高度和拔牙窝的骨密度。结果:PRF在体外实验中能明显促进BMSCs的增殖,提高成骨分化以及钙化能力(P<0.05)。动物实验中,PRF表现出了促进早期伤口愈合的能力。在颊侧骨壁缺损的修复中,组织工程组在6周时骨高度和骨密度分别为(2.63±0.57)mm、(765.19±59.70)HU,较血凝块组[(5.65±2.91)mm、(599.08±53.88)HU]和PRF组[(4.14±1.16)mm、(644.76±65.39)HU]显著增高(P<0.05)。结论:PRF复合BMSCs构建的组织工程骨可以在早期有效地修复拔牙窝骨壁缺损。