全文获取类型
收费全文 | 28581篇 |
免费 | 2737篇 |
国内免费 | 2328篇 |
专业分类
耳鼻咽喉 | 204篇 |
儿科学 | 340篇 |
妇产科学 | 315篇 |
基础医学 | 3704篇 |
口腔科学 | 482篇 |
临床医学 | 3946篇 |
内科学 | 4640篇 |
皮肤病学 | 262篇 |
神经病学 | 1452篇 |
特种医学 | 1093篇 |
外国民族医学 | 21篇 |
外科学 | 2946篇 |
综合类 | 4443篇 |
现状与发展 | 9篇 |
一般理论 | 4篇 |
预防医学 | 1724篇 |
眼科学 | 722篇 |
药学 | 2887篇 |
32篇 | |
中国医学 | 1492篇 |
肿瘤学 | 2928篇 |
出版年
2024年 | 108篇 |
2023年 | 495篇 |
2022年 | 1280篇 |
2021年 | 1635篇 |
2020年 | 1220篇 |
2019年 | 969篇 |
2018年 | 1068篇 |
2017年 | 911篇 |
2016年 | 874篇 |
2015年 | 1379篇 |
2014年 | 1693篇 |
2013年 | 1335篇 |
2012年 | 2007篇 |
2011年 | 2254篇 |
2010年 | 1366篇 |
2009年 | 1083篇 |
2008年 | 1404篇 |
2007年 | 1522篇 |
2006年 | 1401篇 |
2005年 | 1532篇 |
2004年 | 896篇 |
2003年 | 797篇 |
2002年 | 742篇 |
2001年 | 621篇 |
2000年 | 621篇 |
1999年 | 690篇 |
1998年 | 538篇 |
1997年 | 500篇 |
1996年 | 419篇 |
1995年 | 381篇 |
1994年 | 302篇 |
1993年 | 177篇 |
1992年 | 229篇 |
1991年 | 174篇 |
1990年 | 154篇 |
1989年 | 145篇 |
1988年 | 167篇 |
1987年 | 107篇 |
1986年 | 106篇 |
1985年 | 83篇 |
1984年 | 45篇 |
1983年 | 39篇 |
1982年 | 41篇 |
1981年 | 33篇 |
1980年 | 19篇 |
1979年 | 21篇 |
1978年 | 11篇 |
1976年 | 9篇 |
1975年 | 11篇 |
1971年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
分析了1984~1993年期间47例经治的急性视神经炎患者。治疗应用地塞米松10mg、青霉素480万u静脉点滴7天,随后减量。结果治愈35例(74.47%),好转6例(12.76%),无效2例(4.26%),转院及自动出院各2例。47例中11例治疗效果不好者行筛窦开放术后,视力逐渐恢复正常,显示筛窦开放术有其临床实用价值。 相似文献
112.
小鼠经6Gy、15Gy和100Gy全身一次γ线照射后用荧光法测定小肠组织胺含量.实验结果表明,小肠组织胺含量因照射剂量和照后时间不同而变化:6Gy照后每克小肠组织胺含量轻度下降;15Gy和100Gy照后小肠组织胺含量逐渐增加;在照后第三天各组小肠组织胺含量分别为正常的84.0%、149.7%和151.9%.实验同时观察到15Gy照前用WR-2721预防与单纯同剂量照射组相比小肠组织胺增加程度明显缓和.文章中对上述小肠组织胺含量改变的可能机制进行了讨论. 相似文献
113.
114.
目的 利用聚合酶链反应的酶联免疫吸附试验 ,探讨检测自排尿脱落细胞端粒酶活性在膀胱癌早期诊断中的意义。方法 应用 (端粒酶重复序列扩增基础上PCR -ELISA)TRAP -PCR -ELISA方法检测 5 8例膀胱癌患者、 2 5例良性血尿患者及 30例健康体检者尿脱落细胞的端粒酶活性。结果 (1) 5 8例膀胱癌患者尿脱落细胞阳性率为 81 0 % (4 7/ 5 8) ,2 5例良性血尿患者及健康体检者均无端粒酶活性表达。 (2 )TRAP -PCR -ELISA方法检测膀胱癌患者尿脱落细胞端粒酶活性与常规尿细胞形态学镜检间的差别有非常显著性意义 (P <0 0 1)。结论 尿脱落细胞端粒酶活性的检测法对膀胱癌患者的阳性检出率较常规尿细胞形态学方法高 ,可用于膀胱癌的早期诊断。 相似文献
115.
本文观察了频率为20Hz、振幅为0.67mm和作用时间为40min的振动预处理对急性缺氧小鼠肺损伤的影响。结果发现实验组的肺组织匀浆脂质过氧化物LghdPeroxde(LPO)、支气管肺泡灌洗液(BALF)中蛋白含量和白细胞数明显低于对照组(P<0.05)。这表明在特定率数的振动作用下能明显减轻急性缺氧小鼠肺的损伤。 相似文献
116.
Ivermectin for the chemotherapy of bancroftian filariasis: a meta-analysis of the effect of single treatment 总被引:4,自引:4,他引:0
Wu-chun Cao Catharina P. B. Van der Ploeg Anton P. Plaisier I. J. Sivera van der Sluijs J. Dik F. Habbema 《Tropical medicine & international health : TM & IH》1997,2(4):393-403
Summary The efficacy and safety of ivermectin in the treatment of filariasis due to Wuchereria bancrofti was assessed by a meta-analysis of the results from 15 published clinical trials. Seven hundred and forty-eight microfilaraemic patients were enrolled in 7 dose-finding and 8 comparative studies. Administered as a single dose, ivermectin induced nearly complete clearance of microfilariae from the blood from the first day to 30 days post-treatment, followed by gradual recurrence of microfilaraemia and increase in its intensity. Higher doses of ivermectin showed greater clearance effects and maintained lower microfilaraemia levels for a longer time. The adverse reactions caused by the drug were flu-like, transient, generally mild and well tolerated by patients. The frequency and intensity of adverse reactions were strongly associated with pretreatment microfilaria counts in the blood, but independent of dose. The findings of the meta-analysis suggest that ivermectin given at a single annual dose of 200 μg/kg body weight or higher, whether or not in combination with DEC, has great potential for therapeutic strategies to control bancroftian filariasis. 相似文献
117.
Anatomic and spiral computed tomographic study of the genial tubercles for genioglossus advancement.
Shan Kai Yin Hong Liang Yi Wen Ying Lu Jian Guan Hong Min Wu Zhen Yu Cao Dong Zhen Yu Yan Yan Huang Chun Gen Wu 《Otolaryngology--head and neck surgery》2007,136(4):632-637
OBJECTIVE: To measure and compare Chinese mandibular genial tubercles measured anatomically and with computed tomography (CT). STUDY DESIGN AND SETTING: Spiral CT scans were taken of 40 adult human skulls; the superior genial spines were measured using anatomic and CT methods. RESULTS: The height and width of the superior genial spines, mandible thickness, and distance from the menton to the inferior and superior margins of the superior genial spines were 5.82 +/- 0.71, 6.98 +/- 1.35, 11.95 +/- 1.59, 11.08 +/- 2.05, and 16.91 +/- 2.30 mm from anatomic measurements and 6.17 +/- 0.71, 7.01 +/- 1.13, 12.19 +/- 1.64, 10.41 +/- 1.55, and 15.73 +/- 2.12 mm using spiral CT, respectively. The anatomic and CT measurements were correlated. CONCLUSION: Spiral CT of the genial tubercles can help locate the osteotomy in genioglossus advancement. SIGNIFICANCE: This study acquired reference data on Chinese genial tubercles demonstrating that CT measurements of the genial tubercles reflect their anatomy, which should allow accurately locate the osteotomy. 相似文献
118.
We detected the presence and distribution of HBcAg in the liver by immunohistochemistry (ABC method) and the presence of HBV-DNA in serum (spot hybridization) and anti-HBe in serum (ELISA) from 59 cases of hepatitis B hospitalized in our hospital, including 47 cases of CAH, 5 cases of CPH, and 7 cases of subacute fulminant hepatitis. 1. HBcAg in the liver was detected in 25 out of 47 cases (53%) of CAH, in 2 out of 5 cases of CPH and in 4 out of 7 cases of subacute fulminant hepatitis. The total percentage was 53% (31/59). 2. There was no positive correlation between HBV replication activity and liver disease activity (P greater than 0.05). Our results did not support the hypothesis that suggests a direct cytopathic effect of HBV. Oppositely, the fact was that the presence, the amount and the patterns of HBcAg in the liver, and the presence of HBV-DNA in serum were predominant in mild CAH compared with those in severe CAH, predominant in CAH without cirrhosis compared with those in CAH with cirrhosis. There was a tendency of inverse correlation between HBV replication activity and liver disease activity. The results above were in line with the concept that HBcAg expressed on the surface of infected hepatocytes may be relevant target for T lymphocyte cytotoxicity. The results have suggested that an immune response to HBV is present, leading to the destruction of most infected cells. 3. There was a positive correlation between HBV-DNA in serum and HBcAg in the liver (P less than 0.005), indicating that HBV-DNA in serum can represent HBV replication.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
119.
肝动脉化疗,栓塞与肝静脉暂时闭塞治疗肝癌 总被引:1,自引:0,他引:1
本文报道在10例肝癌患者中运用肝静脉暂时闭塞和肝动脉内灌注化疗、栓塞的方法治疗取得较好疗效。7例甲胎蛋白阳性患者5例下降大于50%,2例转阴。4例肿瘤缩小>50%。2例合并肝动-静脉瘘者成功实行碘油栓塞,1例经治疗后肝动-静脉瘘消失。对肝功能的影响与普通介入治疗相同。消化道反应相对较轻。并可提高肿瘤局部药物浓度,延长药物作用时间。配合肝段动脉或靶血管的插管可进一步提高疗效,减少并发症。 相似文献
120.
HLA-DR, DQ genotypes of celiac disease patients and healthy subjects from the West of Ireland 总被引:2,自引:0,他引:2
J. P. Michalski C. C. McCombs T. Arai R. C. Elston T. Cao C. F. McCarthy F. M. Stevens 《Tissue antigens》1996,47(2):127-133
Celiac disease (CD) has one of the strongest class II HLA associations of any human illness. We used DNA-RFLP typing to study the class II HLA genotypes of celiac disease patients from the West of Ireland, the geographic area with the highest rate of celiac disease in the world. We confirmed the high frequency of HLA-DR3 in this population, and we were also able to demonstrate the additional risk of developing celiac disease imparted by HLA-DR7. This was done by clearly distinguishing DR7, DQ2 haplotypes from DR7, DQ9 haplotypes, and by "subtraction analysis" of haplotype frequencies. As reported in other populations, most of the patients without DR3 were heterozygous for DR7 and DR11 or 12 (DR5), or had DR4. We used PCR-RFLP and direct sequencing of amplified DNA to examine HLA-DR4 subtypes. The frequency of HLA-DR4 was markedly decreased in patients compared with controls (p=0.000001) and there was a significant alteration of DR4 subtypes of the patients compared with controls (p=0.0227). Moreover, all of the CD patients (5 of 5) with DR4 had a haplotype associated with the DQB1*0302 allele compared with only 11 of 23 control subjects with DR4. Our results in this population with exceptionally high risk of CD strongly support the DQ heterodimer hypothesis and suggest that the recently described sequence difference between the DQB1*02 alleles of DR3 and DR7 may contribute to a synergistic increased risk when these haplotypes are inherited together. In addition, our findings suggest a role for HLA-DQ in DR4-associated CD. 相似文献