前列腺素E1治疗老年慢性肺心病急性期的疗效观察

目的 :探讨前列腺素E1(PGE1)对老年慢性肺心病急性期的疗效。方法 :对 40例老年慢性肺心病急性期患者应用PGE110 0 μg·d-1静脉滴注 ,疗程 7d。于治疗前后同步检测患者血浆D -二聚体 (D -dimer) ,血清纤维蛋白降解产物 (FDP) ,动脉血氧分压 (PaO2 ) ,及动脉血二氧化碳分压 (PaCO2 )并观察症状体征变化 ,同时与对照组患者及 2 0例健康者进行比较。结果 :两组老年慢性肺心病急性期患者的D -二聚体和FDP显著高于健康组 (P <0 .0 1) ,治疗组病例治疗后D -二聚体及FDP较治疗前显著降低 (P <0 .0 1) ,症状体征显著改善 (P <0 .0 5～ 0 .0 1) ,对照组的D -二聚体 ,FDP及部分症状和体征 ,治疗前后比较差异有显著性 (P <0 .0 5～ 0 .0 1)。治疗后PaO2 两组均显著增高 (P <0 .0 1) ,组间比较无差别 (P >0 .0 5 )。治疗后PaCO2 两组均降低 ,但治疗组降低幅度更明显 (P <0 .0 1)。结论 :PGE1对老年慢性肺心病急性期确有良好疗效     

The effect of cardiovascular morbidity on clinical response provided by tadalafil in patients with erectile dysfunction

We aimed to investigate the association between erectile dysfunction and severity of cardiovascular morbidity and to assess clinical responses to tadalafil of patients in different cardiovascular risk groups. Between November 2019 and August 2020, a total of 258 male patients aged 45–70 years with ED were included. They were divided into three groups according to the Framingham risk score: low-risk (n: 86, 33.3%), intermediate-risk (n: 103, 39.9%) and high-risk (n: 69, 26.8%). At admission, all domains of the International Index of Erectile Function score were worse in high-risk group compared to other risk groups (p < .001). After a 12-week follow-up, a more significant improvement was observed in all domains of erectile function in all risk groups, but high-risk group had lower sexual scores (p < .001). The lowest rate for complete responsiveness to tadalafil was observed in the high-risk group (37.7%). The rate of failure in complete responsiveness was found to be 4.127 times greater with higher Framingham score and 3.102 times greater with higher erectile dysfunction severity at admission. Our preliminary findings show that more severe sexual disorders are observed in high-risk patients with cardiovascular morbidity. Individualised treatment may be important in high-risk group since they may benefit less from tadalafil, and failure in complete responsiveness can be more common in this group.     

Assessment of changes in penile sensation by electrophysiological study after radical prostatectomy: A pilot study

Background:To evaluate the changes in penile sensation by electrophysiological tests in patients who underwent radical prostatectomy (RP) and to demonstrate the role of dorsal penile nerve injury in postoperative erectile dysfunction.Materials and methods:Twenty-six volunteer patients who were eligible for RP were included in the study. Preoperative penile sensory electromyography and the International Index of Erectile Function-5 (IIEF-5) questionnaire were done for each patient. Erectile function assessment and electrophysiological evaluation of penile sensation were repeated at postoperative 3rd and 6th months.Results:Postoperative IIEF-5 scores and electromyography values were significantly lower than preoperative findings (p < 0.05). The IIEF-5 scores in the nerve sparing-RP (NS-RP) group were significantly higher than the non-nerve sparing-RP (NNS-RP) group in the postoperative period. Nerve conduction velocity values in the NS-RP group were also higher than the NNS-RP group at the postoperative 3rd and 6th months. However, these changes were not statistically significant (p > 0.05).Conclusions:Patients who underwent RP have decreased penile sensation due to cavernous nerve damage and a possible dorsal penile nerve injury. The decrease of penile sensation may be associated with postoperative erectile dysfunction.     

Bilateral immediate two-stage breast reconstruction in patients with unilateral breast cancer: Outcomes analysis and risk assessment

IntroductionContralateral prophylactic mastectomy has the potential to decrease the occurrence of cancer and reduce psychological burden. However, it is known that complications after bilateral mastectomy are higher compared with unilateral mastectomy. Our goal was to evaluate outcomes of immediate breast reconstruction in patients undergoing bilateral mastectomy and to compare complication rates between therapeutic and prophylactic sides.Patients and MethodsElectronic medical records of patients with unilateral breast cancer who underwent bilateral mastectomy and immediate reconstruction with expanders were reviewed. Postoperative complications were compared between therapeutic and prophylactic mastectomy sides.ResultsSixty-two patients were analyzed. The overall complication rate after both stages was 23.9% on the therapeutic side and 16.5% on the prophylactic side. Infection was the most common complication on both sides. All infections on the prophylactic mastectomy side were successfully treated with intravenous (IV) antibiotics (salvage rate of 100%), whereas 35.7% of infected tissue expander/implants on the therapeutic mastectomy side were explanted despite treatment.ConclusionCareful counselling of patients undergoing elective contralateral prophylactic mastectomy is essential as complications can develop in either breast after reconstruction.     

Compulsive Conditioned Sexual Responding of Male Japanese Quail in Extinction

Archives of Sexual Behavior - Previous experiments showed that following acquisition of an association between a terry-cloth object conditioned stimulus (CS) and a live female unconditioned...     

脂多糖对胆汁分泌的影响

[目的 ]通过脂多糖对胆汁分泌的影响实验 ,初步探讨引起肝功能障碍及肝内结石形成的机理 .[方法 ]在麻醉状态下 ,直接往实验动物肝内注入脂多糖等实验药物 ,测定相关数据 .[结果 ]脂多糖对胆汁分泌有抑制作用 ,并对胆汁酸、磷脂浓度有降低作用 ,而对胆红素、钙的浓度无显著作用 .[结论 ]脂多糖对胆汁分泌有明显作用 ,对诱发肝功能障碍及形成肝内胆结石有一定的影响     

双苄基异喹啉季铵类化合物的合成及肌肉松驰活性

目的：获得起效快、复原快的肌肉松驰剂。方法：1类化合物以汉防乙甲素为原料,经季铵化制得。Ⅱ类以阿曲库铵的结构为模板,对其1－取代基进行结构改造而得,所有目的化合物的结构经IR、^1HNMR、MS鉴定。结果：设计合成了未见文献报道的11个两类双苄基异喹啉季铵类化合物。结论：初步药理试验表明,目的化合物1c的起效剂量、起效时间与汉肌松相当。     

蛛网膜下腔再出血(附11例报告)

? Objective:To explore the molecular mechanism of G1arrest of thymocytes and splenocytes in mice induced by whole body irradiation(WBI) .Methods:Flow cytometry(FCM) and dotblotwere used to analyze MDM2 m RNA and protein expressions of thymocytes and splenocytes in Kunming mice after whole body irradiation (WBI) with x- rays.Results:The expressions of MDM2 protein of thymocytes in mice increased from 4h to 8h after 2 Gy WBI.There were no significant changes of MDM2 m RNA level of thymocytes and splenocytes from0 to48h after75m Gy or2 Gy WBI.No changes of MDM2 m RNA level were also found in thymocytes or splenocytes of mice4h after0～ 6Gy WBI.Conclusion:These results suggest that ionizing radiation could induce MDM2 protein expression and make G1arrest cells reentering cell cycle. 〔     

Early and late visual prognosis in solar retinopathy

Background: Solar retinopathy was observed in a total of 86 eyes of 58 patients following the solar eclipse over Turkey in April 1976. The visual prognosis and the presence of late complications were evaluated at the early and late periods. Methods: Of the 58 patients, 34 (51 eyes) presented during the first week and came for follow-up examination in the succeeding week, also after 1, 3, 12 and 18 months. After that they were examined at yearly intervals (mean 4.2 years). Twenty-four patients (35 eyes) presented during the period between 1 and 11 years post-eclipse and were followed up for a mean period of 3.4 years. After a period of 15 years, all of the patients were invited for re-examination and nine patients (14 eyes) attended. Results: The improvement in visual acuity was observed to have taken place mostly during the first 2 weeks to 1 month after the eclipse. Further improvement in visual acuity was not observed in any of the eyes after the 18-month examination. The improvement in visual acuity was more prominent and earlier in the eyes that had visual acuity of 0.2 or better initially. Only the eyes with initial visual acuity equal to or better than 0.4 had a chance to improve their acuity to 10/10. Having observed the 51 eyes for mean period of 4.2 years and the 35 eyes for 3.4 years, no change in visual acuity was observed. Among the total of 86 eyes, 9 were found to have pseudolamellar macular holes. Conclusion: Correlation was found between initial visual acuity and the funduscopic appearance after the 2nd week. Fluorescein angiography was not found to be a conclusive test in solar retinopathy. No late complications were observed.