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991.
Shelly Choo Guy Marti Manuel Nastai Jessie Mallalieu Michele A. Shermak 《Obesity surgery》2010,20(10):1422-1428
Background
The aim of this study is to assess skin strength in MWL patients relative to control cosmetic abdominoplasty patients biophysically, biochemically, and histologically. Growing success of weight loss programs has brought about an increase in the MWL population. Skin quality is thought to be impaired by MWL, but there are no compelling studies that have fully addressed the structural mechanisms involved. 相似文献992.
Shingo Shibata Chiori Ueno Tsuyoshi Ito Keitaro Yamanouchi Takashi Matsuwaki Masugi Nishihara 《Age (Dordrecht, Netherlands)》2010,32(2):239-253
Growth hormone (GH) is known to have a pivotal role in the maintenance of skeletal muscle mass. Sarcopenia, the loss of skeletal
muscle mass, is a common phenomenon in aging, and it is widely accepted that sarcopenia is largely attributed to age-related
decline in GH secretion. In the present study, we tested if human growth hormone transgenic rats (GH-TG rats) whose plasma
GH levels are maintained relatively low could be an appropriate model for sarcopenia. Analyses of GH-TG rats revealed that
they exhibit skeletal muscle growth defect as well as atrophy of myofibers. The number of myofibers in tibialis anterior muscle
was comparable to that of WT rats, while the proportion of type I slow myofibers in tibialis anterior muscle was increased
in GH-TG rats after 5 months. Neither increased expression of ubiquitin ligases, MuRF1 and MAFbx, nor indication of apoptotic
cell death was observed. Notably, myogenic differentiation potential of skeletal muscle progenitor cells in GH-TG rats was
lower than WT rats, and this was accompanied by increased adipogenic potential. These results indicate that GH-TG rats could
be a useful model to elucidate the mechanism of sarcopenia induced by reduced GH action and raised the possibility that decreased
GH action may cause an alteration of differentiation potential of skeletal muscle progenitor cells. 相似文献
993.
994.
Rafael E. de la Hoz Michael R. Shohet Jeffrey M. Cohen 《Current allergy and asthma reports》2010,10(2):77-83
The World Trade Center disaster and its recovery work involved a range of hazardous occupational exposures that have not been
fully characterized but that can be reasonably assumed to have the potential to cause mucosal inflammation, preferentially
(but not exclusively) in the upper airway. A high prevalence of rhinosinusitis and upper airway disease (UAD) symptoms was
reported by several early surveys. Clinical studies demonstrated objective, clinically significant, and persistent chronic
perennial rhinosinusitis and UAD—with or without seasonal exacerbation—in a large proportion of patients. Demonstration of
an association between UAD and available exposure indicators has been limited. Atopy seemed to be associated with increased
UAD symptom severity and to be a risk factor for upper, but not lower, airway disease. World Trade Center-related UAD is considered
an irritant-induced disease but not, in many cases, of acute onset. No data thus far suggest an increased upper airway cancer
incidence. 相似文献
995.
Hypertension is an important risk factor for the development of heart failure. Increased production of reactive oxygen species
(ROS) contributes to cardiac dysfunction by activating numerous pro-hypertrophic signaling cascades and damaging the mitochondria,
thus setting off a vicious cycle of ROS generation. The way in which oxidative stress leads to exacerbation of systolic and
diastolic dysfunction is still unclear, however. In skeletal muscle and ischemic myocardium, increased ROS production causes
preferential oxidation of myofibrillar proteins and provides a mechanistic link between oxidative damage and impaired contractility
through disruption of actin-myosin interactions, enzymatic functions, calcium sensitivity, and efficiency of cross-bridge
cycling. In this review, we summarize recent findings in the fields of heart failure and sarcomere biology and speculate that
oxidative damage to myofibrils may contribute to the development of heart failure. 相似文献
996.
Catherine A. Brownstein Paul Wicks 《Clinical orthopaedics and related research》2010,468(10):2581-2585
Background
Osteogenesis imperfecta (OI) is an inherited connective tissue disorder with many phenotypic presentations ranging from mild to severe. It is often called “brittle bone disease.” Treatment consists of physical therapy, surgical interventions, medications and, in some cases, experimental therapies. Because treatment is not standardized and is often experimental, information on the success of different methods is usually not available or well documented. 相似文献997.
998.
Mitnala Sasikala D. Nageshwar Reddy Nitesh Pratap Sanjeev Kumar Sharma P. Reddy Balkumar Anuradha Sekaran Rupa Banerjee D. Bhaskara Reddy 《Indian journal of gastroenterology》2009,28(5):169-174
Background and Objective
The role of Mycobacterium avium ss paratuberculosis (MAP) in the etiopathology of Crohn’s disease (CD) remains controversial, because of conflicting reports demonstrating the presence of MAP-specific insertion sequence from intestinal biopsy tissues of patients clinically diagnosed for the disease. The present study was carried out to investigate the presence of MAP DNA in the intestinal tissues of CD patients to ascertain the relevance of MAP in Indian patients with CD. 相似文献999.
Vijayakumar Raju Muralidharan Srinivasan Chandrasekar Padmanaban Venkatadevanathan Muthubaskaran Rajpal Kanaklal Abhaichand 《Indian Journal of Thoracic and Cardiovascular Surgery》2011,27(1):36-38
Diagnostic evaluation of embolic neurologic events requires the consideration of cardiac causes. Lambl’s Excrescences (LE)are
filiform fronds that occur at sites of valvular closure due to “wear and tear” (Lambl Wien Med Wschr 6:244–247, 1856). The complex form of LE is “giant Lambl’s Excrescences” which results from the adherence of multiple adjacent excrescences
that grow large. We recently had young male adult who presented with features of posterior circulation stroke (basilar) and
detected to have two separate giant Lambl’s Excrescences on the aortic valve and treated successfully. 相似文献
1000.