全文获取类型
收费全文 | 2319篇 |
免费 | 200篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 68篇 |
妇产科学 | 92篇 |
基础医学 | 330篇 |
口腔科学 | 33篇 |
临床医学 | 272篇 |
内科学 | 546篇 |
皮肤病学 | 58篇 |
神经病学 | 207篇 |
特种医学 | 39篇 |
外科学 | 283篇 |
综合类 | 7篇 |
一般理论 | 3篇 |
预防医学 | 239篇 |
眼科学 | 30篇 |
药学 | 100篇 |
中国医学 | 2篇 |
肿瘤学 | 181篇 |
出版年
2024年 | 4篇 |
2023年 | 52篇 |
2022年 | 81篇 |
2021年 | 185篇 |
2020年 | 110篇 |
2019年 | 141篇 |
2018年 | 126篇 |
2017年 | 91篇 |
2016年 | 87篇 |
2015年 | 105篇 |
2014年 | 122篇 |
2013年 | 137篇 |
2012年 | 218篇 |
2011年 | 192篇 |
2010年 | 74篇 |
2009年 | 61篇 |
2008年 | 127篇 |
2007年 | 108篇 |
2006年 | 97篇 |
2005年 | 72篇 |
2004年 | 79篇 |
2003年 | 76篇 |
2002年 | 55篇 |
2001年 | 12篇 |
2000年 | 7篇 |
1999年 | 5篇 |
1998年 | 11篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 4篇 |
1994年 | 7篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1989年 | 2篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1962年 | 1篇 |
1935年 | 2篇 |
1934年 | 1篇 |
1929年 | 1篇 |
排序方式: 共有2524条查询结果,搜索用时 46 毫秒
51.
I. Diana Fernandez Nancy P. Chin Carol M. Devine Ann M. Dozier Camille A. Martina Scott McIntosh Kelly Thevenet-Morrison Hongmei Yang 《American journal of public health》2015,105(10):2167-2174
Objectives. We assessed the effects of a worksite multiple-component intervention addressing diet and physical activity on employees’ mean body mass index (BMI) and the percentage of employees who were overweight or obese.Methods. This group-randomized trial (n = 3799) was conducted at 10 worksites in the northeastern United States. Worksites were paired and allocated into intervention and control conditions. Within- and between-groups changes in mean BMIs and in the percentage of overweight or obese employees were examined in a volunteer sample.Results. Within-group mean BMIs decreased by 0.54 kilograms per meter squared (P = .02) and 0.12 kilograms per meter squared (P = .73) at the intervention and control worksites, respectively, resulting in a difference in differences (DID) decrease of 0.42 kilograms per meter squared (P = .33). The within-group percentage of overweight or obese employees decreased by 3.7% (P = .07) at the intervention worksites and increased by 4.9% (P = .1) at the control worksites, resulting in a DID decline of 8.6% (P = .02).Conclusions. Our findings support a worksite population strategy that might eventually reduce the prevalence of overweight and obesity by minimizing environmental exposures to calorically dense foods and increasing exposures to opportunities for energy expenditure within worksite settings.Sixty-eight percent of adults residing in the United States are overweight or obese,1 and these conditions affect more than 1.4 billion adults worldwide.2 Traditional obesity control strategies, which have focused on changing diet and physical activity (PA) behaviors, provide significant individual benefits3 but are considered insufficient to reduce population disease burdens,4,5 for which broad, population-based approaches are needed.6 In addition to individual biology and behaviors, the physical, social, and cultural environment appears to contribute to the upward trend in population estimates of overweight and obesity7,8 by facilitating high-energy, low-nutrient diets and reducing the need to be physically active to perform activities of daily life.9Worksites are feasible self-contained environments with established communication systems in which interventions manipulating the food and PA environment and the social marketing of lifestyle changes can be implemented. Given that 58.4% of the US population aged 16 years or older is employed,10 worksite interventions have the potential to reach large number of adults11 and can foster the participation of employees in project development and sustainability.12–14 Moreover, participatory worksite interventions address workers’ needs, priorities, and interests and allow strategies to be adapted to the realities of individual sites.13 There is also a business case for weight control programs. In comparison with their nonobese counterparts, overweight and obese employees have higher absenteeism rates, have more work limitations, and are less productive.15–18With these issues in mind, the National Heart, Lung, and Blood Institute developed the Obesity Prevention in the Worksite initiative, a population-based approach to promoting behavioral change through environmental interventions that address prevention and control of weight gain.19 Prior to this initiative, worksite trials were either limited scope interventions, targeting a few aspects of the food or PA environment,9,20–23 or broader scope efforts simultaneously targeting risk factors for cardiovascular disease and cancer (e.g., smoking, diet).24–28 In addition, few studies addressed environmental influences related to excessive weight gain.Here we report the results of Images of a Healthy Worksite, one of the studies that is part of the Obesity Prevention in the Worksite initiative; this comprehensive nutrition and PA intervention was designed to promote healthy lifestyles and to stop the shift to the right of the population body mass index (BMI) curve. In this study, worksites were designated to receive an environmental intervention, and employees participated in intervention design. We hypothesized that mean BMIs among employees at the intervention worksites and the percentages of employees who were overweight or obese would not increase over a 2-year period or would increase less than at control worksites. 相似文献
52.
Camille Chatelle Solveig L. Hauger Charlotte Martial Frank Becker Bernd Eifert Dana Boering Joseph T. Giacino Steven Laureys Marianne Løvstad Petra Maurer-Karattup 《Archives of physical medicine and rehabilitation》2018,99(9):1755-1762
Objectives
To investigate the relation between consciousness and nociceptive responsiveness (ie, Nociception Coma Scale–Revised [NCS-R]), to examine the suitability of the NCS-R for assessing nociception in participants with disorders of consciousness (DOC), and to replicate previous findings on psychometric properties of the scale.Design
Specialized DOC program.Setting
Specialized DOC program and university hospitals.Participants
Participants (N=85) diagnosed with DOC.Interventions
Not applicable.Main Outcome Measures
We prospectively assessed consciousness with the Coma Recovery Scale–Revised (CRS-R). Responses during baseline, non-noxious, and noxious stimulations were scored with the NCS-R and CRS-R oromotor and motor subscales.Results
CRS-R total scores correlated with NCS-R total scores and subscores. CRS-R motor subscores correlated with NCS-R total scores and motor subscores, and CRS-R oromotor subscores correlated with NCS-R total scores as well as verbal and facial expression subscores. There was a difference between unresponsive wakefulness syndrome and minimally conscious state in the proportion of grimacing and/or crying participants during noxious conditions. We replicated previous findings on psychometric properties of the scale but found a different score as the best threshold for nociception.Conclusions
We report a strong relation between the responsiveness to nociception and the level of consciousness. The NCS-R seems to be a valuable tool for assessing nociception in an efficient manner, but additional studies are needed to allow recommendations for clinical assessment of subjective pain experience. 相似文献53.
54.
M. Camille Harris Eric J. Dotseth Bryan T. Jackson Steven D. Zink Paul E. Marek Laura D. Kramer Sally L. Paulson Dana M. Hawley 《Emerging infectious diseases》2015,21(4):646-649
La Crosse virus (LACV), a leading cause of arboviral encephalitis in children in the United States, is emerging in Appalachia. For local arboviral surveillance, mosquitoes were tested. LACV RNA was detected and isolated from Aedes japonicus mosquitoes. These invasive mosquitoes may significantly affect LACV range expansion and dynamics. 相似文献
55.
Camille Tagliaferri Jérôme Salles Jean-François Landrier Christophe Giraudet Véronique Patrac Patrice Lebecque Marie-Jeanne Davicco Audrey Chanet Corinne Pouyet Amélie Dhaussy Alain Huertas Yves Boirie Yohann Wittrant Véronique Coxam Stéphane Walrand 《European journal of nutrition》2015,54(7):1139-1149
56.
Eubanks August Coulibaly Bakary Dembélé Keita Bintou Anoma Camille DAH Ter Tiero Elias Mensah Ephrem Maradan Gwenaëlle Bourrelly Michel Mora Marion Riegel Lucas Rojas Castro Daniela Yaya Issifou Spire Bruno Laurent Christian Sagaon-Teyssier Luis 《AIDS and behavior》2022,26(11):3524-3537
AIDS and Behavior - We investigated the rate and predictors of ineffective HIV protection in men who have sex with men (MSM) taking pre-exposure prophylaxis (PrEP) in a prospective cohort study... 相似文献
57.
Sk Masum Billah Tarana E. Ferdous Patrick Kelly Camille Raynes-Greenow Abu Bakkar Siddique Nuzhat Choudhury Tahmeed Ahmed Stuart Gillespie John Hoddinott Purnima Menon Michael John Dibley Shams El Arifeen 《Maternal & child nutrition》2022,18(1):e13267
Adequate dietary diversity among infants is often suboptimal in developing countries. We assessed the impact of nutrition counselling using a digital job aid on dietary diversity of children aged 6–23 months using data from a cluster randomised controlled trial in Bangladesh. The trial had five arms, each with 25 clusters. The four intervention arms provided counselling using a digital job aid and different prenatal and post-natal combinations of lipid-based supplements and the comparison arm with usual practice. We enrolled 1500 pregnant women and followed them until the children reached their second birthday. We developed a tablet-based system for intervention delivery, data collection and project supervision. We combined the four intervention arms (n = 855), in which community health workers (CHWs) provided age-appropriate complementary feeding counselling, to compare against the comparison arm (n = 403). We calculated the outcome indicators from the children's 24-h dietary recalls. Overall, the intervention increased the mean dietary diversity score by 0.09 (95% confidence interval [CI]: 0.2–0.16) and odds of minimum dietary diversity by 18% (95% CI: 0.99–1.40). However, there was a significant interaction on the effect of the intervention on dietary diversity by age. The mean dietary diversity score was 0.24 (95% CI: 0.11–0.37) higher in the intervention than in the comparison arm at 9 months and 0.14 (95% CI: 0.01–27) at 12 months of age. The intervention effect was non-significant at an older age. Overall, consumption of flesh food was 1.32 times higher in the intervention arm (odds ratio [OR] 1.32, 95% CI: 1.11–1.57) in 6–23 months of age. The intervention significantly improved child dietary diversity score in households with mild and moderate food insecurity by 0.27 (95% CI: 0.06–0.49) and 0.16 (0.05–27), respectively, but not with food-secure and severely food-insecure households. Although the study did not evaluate the impact of digital job aid alone, the findings indicate the utility of nutrition counselling by CHWs using a digital job aid to improve child feeding practices in broader programmes. 相似文献
58.
Guillaume Harl Camille Kowalski Juan Dubrot Dale Brighouse Gaëlle Clavel Robert Pick Natacha Bessis Jennifer Niven Christoph Scheiermann Monique Gannag Stphanie Hugues 《The Journal of experimental medicine》2021,218(6)
Lymphatic endothelial cells (LECs) present peripheral tissue antigens to induce T cell tolerance. In addition, LECs are the main source of sphingosine-1-phosphate (S1P), promoting naive T cell survival and effector T cell exit from lymph nodes (LNs). Autophagy is a physiological process essential for cellular homeostasis. We investigated whether autophagy in LECs modulates T cell activation in experimental arthritis. Whereas genetic abrogation of autophagy in LECs does not alter immune homeostasis, it induces alterations of the regulatory T cell (T reg cell) population in LNs from arthritic mice, which might be linked to MHCII-mediated antigen presentation by LECs. Furthermore, inflammation-induced autophagy in LECs promotes the degradation of Sphingosine kinase 1 (SphK1), resulting in decreased S1P production. Consequently, in arthritic mice lacking autophagy in LECs, pathogenic Th17 cell migration toward LEC-derived S1P gradients and egress from LNs are enhanced, as well as infiltration of inflamed joints, resulting in exacerbated arthritis. Our results highlight the autophagy pathway as an important regulator of LEC immunomodulatory functions in inflammatory conditions. 相似文献
59.
Elio Schouppe Camille Mommer Kiavash Movahedi Damya Laoui Yannick Morias Conny Gysemans Ariane Luyckx Patrick De Baetselier Jo A. Van Ginderachter 《European journal of immunology》2013,43(11):2930-2942
Tumor growth coincides with an accumulation of myeloid‐derived suppressor cells (MDSCs), which exert immune suppression and which consist of two main subpopulations, known as monocytic (MO) CD11b+CD115+Ly6G?Ly6Chigh MDSCs and granulocytic CD11b+CD115?Ly6G+Ly6Cint polymorphonuclear (PMN)‐MDSCs. However, whether these distinct MDSC subsets hamper all aspects of early CD8+ T‐cell activation — including cytokine production, surface marker expression, survival, and cytotoxicity — is currently unclear. Here, employing an in vitro coculture system, we demonstrate that splenic MDSC subsets suppress antigen‐driven CD8+ T‐cell proliferation, but differ in their dependency on IFN‐γ, STAT‐1, IRF‐1, and NO to do so. Moreover, MO‐MDSC and PMN‐MDSCs diminish IL‐2 levels, but only MO‐MDSCs affect IL‐2Rα (CD25) expression and STAT‐5 signaling. Unexpectedly, however, both MDSC populations stimulate IFN‐γ production by CD8+ T cells on a per cell basis, illustrating that some T‐cell activation characteristics are actually stimulated by MDSCs. Conversely, MO‐MDSCs counteract the activation‐induced change in CD44, CD62L, CD162, and granzyme B expression, while promoting CD69 and Fas upregulation. Together, these effects result in an altered CD8+ T‐cell adhesiveness to the extracellular matrix and selectins, sensitivity to FasL‐mediated apoptosis, and cytotoxicity. Hence, MDSCs intricately influence different CD8+ T‐cell activation events in vitro, whereby some parameters are suppressed while others are stimulated. 相似文献
60.
Bouvet Cyrille Battin Clémence Cappelaere Camille Leroy-Hatala Claire 《Community mental health journal》2021,57(5):853-863
Community Mental Health Journal - The community-based mental health organizations known as “Clubhouses” have existed since the 1940s in the United States, and the model has since spread... 相似文献