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61.
Expression of connexin36 in the adult and developing rat brain 总被引:12,自引:0,他引:12
Belluardo N Mudò G Trovato-Salinaro A Le Gurun S Charollais A Serre-Beinier V Amato G Haefliger JA Meda P Condorelli DF 《Brain research》2000,865(1):695-138
The distribution of connexin36 (Cx36) in the adult rat brain and retina has been analysed at the protein (immunofluorescence) and mRNA (in situ hybridization) level. Cx36 immunoreactivity, consisting primarily of round or elongated puncta, is highly enriched in specific brain regions (inferior olive and the olfactory bulb), in the retina, in the anterior pituitary and in the pineal gland, in agreement with the high levels of Cx36 mRNA in the same regions. A lower density of immunoreactive puncta can be observed in several brain regions, where only scattered subpopulations of cells express Cx36 mRNA. By combining in situ hybridization for Cx36 mRNA with immunohistochemistry for a general neuronal marker (NeuN), we found that neuronal cells are responsible for the expression of Cx36 mRNA in inferior olive, cerebellum, striatum, hippocampus and cerebral cortex. Cx36 mRNA was also demonstrated in parvalbumin-containing GABAergic interneurons of cerebral cortex, striatum, hippocampus and cerebellar cortex. Analysis of developing brain further revealed that Cx36 reaches a peak of expression in the first two weeks of postnatal life, and decreases sharply during the third week. Moreover, in these early stages of postnatal development Cx36 is detectable in neuronal populations that are devoid of Cx36 mRNA at the adult stage. The developmental changes of Cx36 expression suggest a participation of this connexin in the extensive interneuronal coupling which takes place in several regions of the early postnatal brain. 相似文献
62.
Bombardieri T Cafiero C Fiumanò F Morabito C Palmanova A Rispoli F Vasile R 《Chirurgia italiana》2000,52(5):611-614
Taking as their starting point a case of greater omental torsion recently observed in their surgical department, the authors carefully review the topic and the relevant literature data. This is a rare condition, which though presenting diagnostic difficulties which make it hard to identify preoperatively, poses no problems of a therapeutic nature. 相似文献
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64.
The authors describe a case of intestinal cystic pneumatosis in a patient submitted to gastric banding and then proceed with a critical review of the literature on the subject, examining the state of the art with regard to the pathogenetic hypotheses and the clinical manifestations of the disease and outlining the advantages of the instrumental investigations employed. On the basis of clinical considerations, an integrated pathogenetic hypothesis is advanced which takes account of the various indications expressed in the literature. In particular, recurrent vomiting is believed to bring about epithelial microlesions which, in the presence of severe respiratory impairment, the execution of endoscopic examinations and a mainly carbohydrate-based diet, are thought to cause onset of cystic pneumatosis. 相似文献
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66.
BACKGROUND: Surgical treatment in the patient effected by secondary hyperparathyroidism consists in subtotal parathyroidectomy or total parathyroidectomy plus autotransplantation of parathyroid tissue. METHODS: The results obtained with surgical treatment of 6 patients observed in the years 1995-1996 are analyzed. Two glands were hyperplastic in four patients, 3 in the others. Every patient was submitted to a subtotal parathyroidectomy. RESULTS: Postoperative course was marked by transient hypoparathyroidism in one case. After 18 months of follow-up, no recurrences were observed. CONCLUSIONS: It is pointed out that in case of secondary hyperparathyroidism subtotal parathyroidectomy represents the surgical treatment of choice, according with literature data. Otherwise total parathyroidectomy plus autotransplantation, characterized by a more complex surgical technique, lead to the same results. 相似文献
67.
Ciotta L Stracquadanio M Pagano I Andò A Valenti O Roccasalva L 《Minerva ginecologica》2012,64(1):15-22
AIM AND METHODS: Phytoestrogens are plant substances that have estrogenic properties; they haven't steroid structure but they are heterocyclic phenols and for this reason are similar to 17 β estradiol from the functional and structural point of view; they compete for the same receptor sites of endogenous estrogens, but with an activating capacity a thousand times lower. For this reason, the isoflavones are an alternative to hormone-replacement treatment: they are prescribed to all those women who cannot be treated with HRT for several contraindications, such as thrombosis or breast tumor familiarity. The aim of our study was to demonstrate the effectiveness of soy isoflavones on menopausal symptoms. RESULTS AND CONCLUSION: In our experience, literature data were confirmed, with a 40% reduction of the vasomotor symptoms after 6 months of treatment. Associated with this improvement, there is also the reduction in the degree of insomnia and depressive symptoms. The musculoskeletal pains, however, are not reduced significantly as no positive change was found on vaginal dryness, a major cause of dyspareunia in postmenopausal period. 相似文献
68.
Enrique Soto-Perez-De-Celis Kah Poh Loh Capucine Baldini Nicolò Matteo Luca Battisti Yanin Chavarri-Guerra Nienke A. De Glas 《Expert opinion on investigational drugs》2013,22(10):787-801
ABSTRACTIntroduction: One-third of breast cancer (BC) cases worldwide occur in women aged 65 years and older, with 10 to 15% overexpressing the human epidermal growth factor receptor 2 (HER2). Although several HER2-targeted therapies have been developed, the lack of data regarding their use in older patients hampers evidence-based decision-making for this population.Areas Covered: We review current evidence on the efficacy and safety of HER2-targeted therapies in older adults with BC, focusing on approved therapies such as trastuzumab, lapatinib, pertuzumab, ado-trastuzumab-emtansine, and neratinib. Additionally, we discuss drugs under development to target the HER2-receptor, and to overcome resistance to existing therapies. Finally, we highlight the cardiotoxicity of HER2-targeted drugs among older adults.Expert Opinion: Older adults are underrepresented in trials of HER2-targeted therapies in BC. We propose strategies to increase recruitment of older adults in clinical trials in order to increase the evidence base to treat this growing population. 相似文献
69.
奇乳海参中两个具有抗真菌活性的三萜皂苷 总被引:2,自引:0,他引:2
目的:研究奇乳海参体内的化学成分,寻找结构新颖具有抗真菌活性的三萜皂苷类成分。方法:应用多种色谱分离技术对奇乳海参体内的化学成分进行分离纯化,根据化合物的理化性质,波谱数据及化学方法鉴定其结构。结果:分离得到2个三萜皂苷化合物,分别为axilogoside A(1)和holothurin B(2),并对其抗真菌活性进行了研究(4≤MIC80≤16μg·mL^-1)。结论:化合物1为一新的三萜皂苷化舍物,化合物2为首次从奇乳海参中分离得到,它们均显示一定的抗真菌活性。 相似文献
70.
Emilio Bria MD Federica Cuppone MD Diana Giannarelli PhD Michele Milella MD Enzo Maria Ruggeri MD Isabella Sperduti PhD Paola Pinnarò MD Edmondo Terzoli MD Francesco Cognetti MD Paolo Carlini MD 《Cancer》2009,115(15):3446-3456