全文获取类型
收费全文 | 4333篇 |
免费 | 447篇 |
国内免费 | 259篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 24篇 |
妇产科学 | 42篇 |
基础医学 | 519篇 |
口腔科学 | 59篇 |
临床医学 | 636篇 |
内科学 | 632篇 |
皮肤病学 | 40篇 |
神经病学 | 204篇 |
特种医学 | 155篇 |
外国民族医学 | 1篇 |
外科学 | 391篇 |
综合类 | 707篇 |
一般理论 | 1篇 |
预防医学 | 319篇 |
眼科学 | 144篇 |
药学 | 422篇 |
7篇 | |
中国医学 | 324篇 |
肿瘤学 | 389篇 |
出版年
2024年 | 18篇 |
2023年 | 87篇 |
2022年 | 218篇 |
2021年 | 261篇 |
2020年 | 226篇 |
2019年 | 174篇 |
2018年 | 171篇 |
2017年 | 156篇 |
2016年 | 124篇 |
2015年 | 215篇 |
2014年 | 256篇 |
2013年 | 219篇 |
2012年 | 330篇 |
2011年 | 343篇 |
2010年 | 253篇 |
2009年 | 178篇 |
2008年 | 204篇 |
2007年 | 214篇 |
2006年 | 197篇 |
2005年 | 183篇 |
2004年 | 125篇 |
2003年 | 142篇 |
2002年 | 95篇 |
2001年 | 98篇 |
2000年 | 93篇 |
1999年 | 79篇 |
1998年 | 55篇 |
1997年 | 50篇 |
1996年 | 46篇 |
1995年 | 50篇 |
1994年 | 40篇 |
1993年 | 22篇 |
1992年 | 26篇 |
1991年 | 16篇 |
1990年 | 8篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 5篇 |
1986年 | 9篇 |
1985年 | 12篇 |
1984年 | 7篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1969年 | 1篇 |
排序方式: 共有5039条查询结果,搜索用时 15 毫秒
971.
目的:探讨应用髂腹股沟入路治疗复杂髋臼骨折的方法及临床疗效。方法:回顾性分析2011年9月至2015年10月,采用髂腹股沟入路手术治疗,并获得随访的13例复杂髋臼骨折的患者资料。其中男性10例,女性3例;年龄24~58岁,平均36.8岁;伤后至手术时间5~13 d,平均8 d;骨折按Letournel-Judet分型:双柱骨折8例,前方伴后半横型骨折3例,T型骨折2例。术中通过髂腹股沟入路复位固定前后柱,术后按照Matta复位标准评估复位质量,按照改良的D’Aubigne-Postel评分标准评价髋关节功能。结果:13例患者均获得随访,随访时间8~49个月,平均23.4个月。术后按照Matta复位标准评估复位质量,优8例,良4例,差1例,优良率92.3%;按照改良的D’Aubigne-Postel评分标准评价髋关节功能,优7例,良4例,差2例,优良率84.6%。2例发生伤口脂肪液化,1例经换药后愈合,1例经手术室再次清创后愈合。1例术后拔除引流管后管口持续渗血,经腹带加压输血及应用止血药后创面愈合。4例发生股外侧皮神经损伤,均于术后3个月到半年逐渐减轻并恢复。1例复位差的患者于术后半年发生创伤性关节炎。结论:正确评估髋臼骨折类型,周密的术前计划,术中仔细操作,通过髂腹股沟入路,可以对前方伴后方横行骨折、大部分双柱骨折及部分T型骨折进行复位及固定,并获得满意的临床疗效。 相似文献
972.
Zhongyue Ren Yan Hong Yalan Huo Lingling Peng Huihui Lv Jiahui Chen Zhihua Wu Cuixiang Wan 《Nutrients》2022,14(22)
In modern society, where new diseases and viruses are constantly emerging, drugs are still the most important means of resistance. However, adverse effects and diminished efficacy remain the leading cause of treatment failure and a major determinant of impaired health-related quality of life for patients. Clinical studies have shown that the disturbance of the gut microbial structure plays a crucial role in the toxic and side effects of drugs. It is well known that probiotics have the ability to maintain the balance of intestinal microecology, which implies their potential as an adjunct to prevent and alleviate the adverse reactions of drugs and to make medicines play a better role. In addition, in the past decade, probiotics have been found to have excellent prevention and alleviation effects in drug toxicity side effects, such as liver injury. In this review, we summarize the development history of probiotics, discuss the impact on drug side effects of probiotics, and propose the underlying mechanisms. Probiotics will be a new star in the world of complementary medicine. 相似文献
973.
Xia Yulong Fan Fangfang Huo Ya Wei Yaping Huang Meiqing Zhang Yan Li Jianping Liu Lishun Zhou Jing Huo Yong 《Journal of clinical hypertension (Greenwich, Conn.)》2022,24(11):1473
The aim of this study was to investigate the association between baseline resting heart rate (RHR) and all‐cause death in the China Stroke Primary Prevention Trial (CSPPT). A post hoc analysis was conducted using data from 20,648 hypertensive adults without cardiovascular disease in the CSPPT and with baseline RHR data available. Over a median follow‐up duration of 4.5 years, the baseline RHR and risk for all‐cause death had a nonlinear relationship. The risk of all‐cause death was higher in participants with an RHR ≥85 bpm (hazard ratio 1.42; 95% confidence interval 1.03–1.96, p = .031) than in those with a baseline RHR of 75–80 bpm. The effect of RHR on all‐cause death during the treatment period was modified by the folate level (p = .020) and systolic blood pressure (SBP) during treatment(p = .056). The effect of RHR on the risk of all‐cause death was stronger when the folate level was low than when it was high; the risk was higher when the RHR was < 75 bpm or ≥80 bpm than when it was 75–80 bpm. RHR had a greater effect on the risk of all‐cause death when SBP during treatment was well controlled than when it was not; again, the risk was higher when the RHR was < 75 bpm or ≥80 bpm than when it was 75–80 bpm. A higher baseline RHR resulted in an increased risk of all‐cause mortality in Chinese adults with hypertension but no history of stroke or myocardial infarction. 相似文献
974.
Xinwei Chen Ruiying Li Xiaoyu Hou Yuqin Wang Mingming Pan Ning Kang Yinghao Yuchi Wei Liao Xiaotian Liu Zhenxing Mao Wenqian Huo Chongjian Wang Jian Hou 《Nutrients》2022,14(17)
Background: To assess the associations of platelet traits and obesity indices with aging biomarkers (telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN)). Methods: A cross-sectional study was performed among 5091 rural Chinese adults. Obesity indices (waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR)) and platelet traits (plateletcrit (PCT), platelet large cell ratio (P-LCR), mean platelet volume (MPV) and platelet distribution width (PDW)) were collected by physical examination. The aging biomarkers were determined by quantitative real-time polymerase chain reaction. Generalized linear regression models and mediation analysis were applied to explore the relationships between platelet traits, obesity indices, and aging biomarkers. Results: The mean age of the participants was 56 years (range: 18–79). Each one-unit increment in WC, WHR and WHtR were related to a 0.316 (95% confidence interval (CI): −0.437, −0.196), 0.323 (95% CI: −0.513, −0.134) and 0.277 (95% CI: −0.400, −0.153) decrease in relative TL; or a 0.102 (95% CI: −0.197, −0.007), 0.109 (95% CI: −0.258, −0.041) and 0.101 (95% CI: −0.199, −0.004) decrease in relative mtDNA-CN. The proportions of obesity indices with aging biomarkers mediated by platelet indices ranged from 2.85% to 10.10%. Conclusions: Increased central obesity indices in relation to shortened relative TL or decreased mtDNA-CN were mediated by platelet traits, indicating that obesity in association with the accelerated aging process may be partially attributable to abnormal platelet activity. 相似文献
975.
976.
目的::研究扫描信号强度(SS)对光学相干断层扫描血管成像(OCTA)测量正常人黄斑浅层血流密度的影响。方法::系列病例研究。对2020年9—12月在北京同仁医院进行健康体检的某事业单位在职职工进行系统眼科检查,应用光学相干断层扫描(OCT)和OCTA测量平均黄斑节细胞内丛状层(mGCIPL)厚度和黄斑6 mm×6 m... 相似文献
977.
Jie Ma Xu-Yun Hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Xin Gao Han Zhang Jian-Guang Xu 《Korean journal of radiology》2022,23(10):986
ObjectiveWhether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs.Materials and MethodsThis study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent 18F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called “individual contribution index” were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUVmean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association.ResultsThe means ± standard deviations of the individual contribution index were (0.697 ± 10.9) × 10-3 and (0.0967 ± 0.0545) × 10-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785–0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUVmean of the limbic network (p < 0.001).ConclusionThe individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs. 相似文献
978.
979.
Haowei Lu Heren Wang Xingfa Huo Guoyuan Li 《The Journal of international medical research》2022,50(9)
Persistent left superior vena cava (PLSVC) is a common venous variation that is usually accompanied by an absence of the left brachiocephalic vein, and displays a higher incidence in patients with congenital heart disease. Here, the case of a 57-year-old male patient who was found to have PLSVC on chest computed tomography (CT) during screening for gastric cancer metastasis at the Affiliated Hospital of Qinghai University, is described. Further coronal CT and three-dimensional reconstruction of the chest revealed the patient''s double superior vena cava (DSVC), double odd veins, and left brachiocephalic vein dysplasia. The patient did not have congenital heart disease and the case was associated with dysplasia of the left brachiocephalic vein, indicating an unusual and rare venous abnormality. At the time of writing, the patient was receiving antitumour therapy. 相似文献