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91.
Â. Novais C. Sousa J. de Dios Caballero A. Fernandez-Olmos J. Lopes H. Ramos T. M. Coque R. Cantón L. Peixe 《European journal of clinical microbiology & infectious diseases》2014,33(8):1391-1399
Reliable, quick and low-cost methods are needed for the early detection of multidrug-resistant and highly virulent high-risk B2 and D Escherichia coli clones or clonal complexes (HiRCC). Matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) seems to have a good discriminatory potential at different subspecies levels, but it was never evaluated for the discrimination of E. coli clones. We assessed the potential of MALDI-TOF MS coupled to multivariate data analysis to discriminate representative E. coli B2 and D HiRCC. Seventy-three E. coli isolates from B2 (including ST131 and B2 non-ST131 clones) and D (ST69, ST393, ST405) with variable pulsed-field gel electrophoresis (PFGE) patterns, origins and dates (1980–2010) were tested. MS spectra were acquired from independent extracts obtained from different plate cultures in two different Microflex LT MALDI-TOF devices (Bruker) after a standard extraction procedure. MALDI-TOF MS fingerprinting analysis revealed a good discriminatory ability between the four HiRCC analysed (ST131, ST69, ST405, ST393) and between B2 ST131 and other B2 non-ST131 isolates. Clusters defined by MALDI-TOF MS were consistent with the clonal complexes assigned by multilocus sequence typing (MLST), although differences were detected regarding the composition of clusters obtained by the comparison of PFGE profiles. We demonstrate, for the first time, that characteristic mass fingerprints of different E. coli HiRCC are sufficiently discriminatory and robust to enable their differentiation by MALDI-TOF MS, which might represent a promising tool for the optimisation of infection control, individual patient management and large-scale epidemiological studies of public health relevance. The good correlation between phenotypic and genotypic features further corroborates phylogenetic relationships delineated by MLST. 相似文献
92.
Rocio Ramos‐Medina Aurea García‐Segovia Juana Gil Javier Carbone Angel Aguarón de la Cruz Ansgar Seyfferth Bárbara Alonso Jorge Alonso Juan A. León Diana Alecsandru Elena Meliá Elena Carrillo de Albornoz Daniel Ordoñez Isabel Santillán Victoria Verdú Jose Maria Garcia Ruiz de Morales Marcos López‐Hoyos Arturo López Larios Almudena Sampalo Pedro Caballero Luis Ortiz Quintana Eduardo Fernández‐Cruz Silvia Sánchez‐Ramón 《American journal of reproductive immunology (New York, N.Y. : 1989)》2014,71(5):458-466
93.
Immediate postoperative imaging after uncomplicated endoscopic approach to the anterior skull base: is it necessary?
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Vicente Plaza Myriam Calle Jesús Molina Santiago Quirce Joaquín Sanchis José Luis Viejo Fernando Caballero 《Archivos de bronconeumología》2012
The understanding of physicians and the skill of patients in the use of inhalers continues to be inadequate. 相似文献
97.
Montoro-García S Hernández-Romero D Jover E García-Honrubia A Vilchez JA Casas T Martínez P Climent V Caballero L Valdés M Marín F 《European Journal of Internal Medicine》2012,23(2):169-174
BackgroundThe growth differentiation factor 15 (GDF-15) has been shown up-regulated in stress conditions and to have regulatory actions in myocyte hypertrophy. We hypothesized that GDF-15 could be related to disease severity and functional status in patients with hypertrophic cardiomyopathy (HCM).Methods and resultsWe performed a study which includes 102 consecutive outpatient HCM subjects, 73% males, aged 47.1 ± 14.6 years. A complete history and clinical examination was performed, including 12-lead electrocardiogram, echocardiography, symptom-limited treadmill exercise, 24-hour ECG-Holter monitoring, and magnetic resonance with Gadolinium. Several biomarkers, associated with myocardial remodeling and damage, were compared to GDF-15 levels. The assays were performed with commercial ELISAs or standardized methods when available. There was a significant association between GDF-15 levels and comorbidities, being higher in hypertension (p = 0.001), diabetes (p = 0.030), atrial fibrillation (p = 0.012), dyspnea (p = 0.020) and NYHA ≥ II functional class (p = 0.037). GDF-15 levels were positively correlated with clinical variables (age, worse exercise capacity and mild renal dysfunction) and biomarkers of interstitial remodeling, such as metalloproteinase-2 (r: 0.40; p = 0.009), N-terminal pro-B-type natriuretic peptide (r: 0.28; p = 0.049), high-sensitivity troponin T (r: 0.30; p = 0.003) and von Willebrand factor (r: 0.33; p = 0.001). Multivariate analysis was assessed to estimate the involvement of these different factors in the GDF-15 levels, confirming the independent implication of severe dyspnea and functional status.ConclusionsThe present results show that higher levels of GDF-15 are associated to conditions of severe disease in HCM. Hence, GDF-15 is suggested as a novel marker related to the severity and could represent a further useful tool in monitoring functional capacity of HCM patients. 相似文献
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Juan J. Grau MD PhD Gabriel Zanon MD PhD Carlos Caso MD Xavier Gonzalez MD Araceli Rodriguez MD Miguel Caballero MD PhD Albert Biete MD PhD 《Annals of surgical oncology》2013,20(9):2822-2827
Background
Many women covered by the Spanish public health system also have an extra private insurance policy for gynecological examinations and routine annual mammography. We retrospectively analyzed the long-term survival rates in these patients when diagnosed with breast cancer.Methods
We analyzed the survival and prognostic factors in patients diagnosed with breast cancer who were referred to a medical oncology unit for multidisciplinary treatment covered by private health insurance.Results
Between 1994 and 2009, a total of 434 patients with breast tumor were analyzed: 33 in situ and 401 infiltrating. Among the infiltrating carcinomas, 38 were stage IV and 363 were stage I, II, or III. With a median follow-up of 62 months, the 5-year global survival rate was 91 %: 97 % for stage I, 94 % for stage II, and 77 % for stage III tumors. In the patients diagnosed by routine mammography, the 5-year survival rate was 96 %, compared with 86 % in those consulting their gynecologist after breast self-examination or for other symptoms (p = 0.0159). Seventy-four percent were treated conservatively and experienced better survival than the 26 % who underwent mastectomy (p = 0.0024). Patients with disease with positive hormone receptors had a better survival rate (p = 0.0264); hormone receptor status was the only independent prognostic factor in the Cox multivariate analysis. Postmenopausal patients who received adjuvant tamoxifen plus exemestane had a better prognosis than those who received tamoxifen alone (p = 0.0203).Conclusions
Long-term survival rate was high in breast cancer patients with extra private insurance coverage. This is probably because disease was diagnosed at an early stage. 相似文献100.