环氧司坦对胎盘滋养层、黄体细胞及胚胎与子宫内膜共培养的影响

环氧司坦(2-氰基-3,17 α-二羟基-4β,17β-二甲基-4α,5α-环氧-雄甾烯(epostane)被认为是颇有希望的止孕药物,国外已应用于临床,为了进一步探讨环氧司坦的止孕机理,我们研究了它对离体人胎盘滋养层细胞和豚鼠黄体细胞的直接作用及对hCG的促黄体激素生成作用和小鼠胚胎与子宫内膜“共培养”的影响。     

Expression of blood group A antigens in human bone marrow cells

We have studied the appearance of blood group A-activity during hematopoiesis in human bone marrow cells by the use of the blood group A-specific lectin from Vicia cracca. Cells that bound the lectin were identified using antiserum against the lectin followed by rosetting with protein A-containing Staphylococcus aureus cells. Only cells of the erythroid lineage from blood group A individuals formed staphylococcal rosettes. A-activity occurred in basophilic normoblasts and later stages of erythropoiesis, whereas pronormoblasts were negative. The appearance of blood group A-activity coincided roughly with the onset of hemoglobin synthesis and slightly later than the expression of the major sialoglycoprotein of erythrocytes, glycophorin A. Glycophorin A did not, however, contain blood group A-activity when analyzed by immunoprecipitation and gel electrophoresis.     

Sulfatide as a biochemical marker in cerebrospinal fluid of patients with vascular dementia

The myelin-associated glycosphingolipid sulfatide in cerebrospinal fluid (CSF) was investigated in 20 patients with vascular dementia (VAD), 43 with Alzheimer's disease (AD) and 20 age-matched controls. The sulfatide concentration in the VAD group (307 +/- 118 nmol/l) was significantly (p less than 0.0001) higher than that in controls (145 +/- 86 nmol/l) and the AD group (178 +/- 79 nmol/l). Among the VAD patients, 8/20 had a significantly increased concentration of sulfatide (greater than mean + 2 S.D.), as compared with controls, while only 2/43 of the AD patients had a sulfatide concentration above this level. It is suggested that the elevated concentration of sulfatide in CSF from VAD patients reflects demyelination. Furthermore, sulfatide determinations, when combined with clinical findings, may be of diagnostic value, for discriminating between VAD and AD.     

参数设置对多层螺旋CT三维重建误差的影响

研究多层螺旋CT三维重建性能与几个主要参数之间的关系。用一台多层螺旋CT对同一个试验物品在不同参数下扫描成像，然后比较和分析不同参数下三维重建结果的误差大小。结果显示层厚、螺距等参数设置对三维成像质量有很大的影响。     

Endometrial carcinoma staging by MR imaging

The potential of magnetic resonance (MR) imaging in the detection of endometrial carcinoma and in the assessment of its extent was evaluated prospectively in 51 patients clinically suspected of having the disease. MR imaging findings were compared with the results of surgical-pathologic staging and lymph node sampling following hysterectomy. Histologic findings showed 45 patients to have endometrial carcinoma, three to have no residual tumor after dilatation and curettage, and three to have adenomatous hyperplasia of the endometrium. MR imaging demonstrated an endometrial abnormality in 43 of the 51 patients (84%). Endometrial carcinoma could not be differentiated from adenomatous hyperplasia or blood clots. Therefore, MR imaging was not specific for tumor detection, and histologic diagnosis remains essential. The overall accuracy of MR imaging in staging endometrial carcinoma was 92%; its overall accuracy in demonstrating the depth of myometrial invasion was 82%. Demonstration of lymphadenopathy and adnexal or peritoneal metastases by MR imaging was suboptimal.     

颈淋巴结阳性的头颈癌患者适形放疗后颈部复发：行救治性颈淋巴清扫抑或放弃？

对头颈癌适形放疗后局部复发的患者行救治性颈淋巴清扫术的作用还缺乏认识。该文对550例颈淋巴结阳性并接受放疗的头颈癌患者进行回顾性分析，平均放疗剂量为74．4Gy，其中133例（24％）行化疗。341例行颈淋巴清扫术，209例观察，并随访颈淋巴结的复发情况。