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Objective
To characterize the clinical behavior of rare sinonasal malignancies.Methods
Clinical data from the cases of rare sinonasal malignancies at Gujarat Cancer and Research Institute during 2001–2007 were extracted. Data for histologic type of tumor, tumor stage and survival were analyzed.Results
Eighty-nine cases of the non-squamous cell malignancy were identified. The mean patient age was 54 years. In this study, we found minor salivary gland tumor in 31 patients, sarcoma in 19 patients, spindle cell carcinoma (SpCC) in 19 patients, undifferentiated carcinoma in 9 patients, lymphoma in 6 patients and melanoma in 3 patients. Adenoid cystic carcinoma exhibited the best survival rate (3 years survival rate was 77%), whereas melanoma and undifferentiated carcinoma exhibited poor survivals (1 year survival was 25% and 33%, respectively and 3 years survival rate is 0%).Conclusions
Adenoid cystic carcinoma is the most common squamous cell carcinoma (SCC) of the sinonasal track. Survival for the patients with undifferentiated carcinoma and melanoma involving the sinonasal track is poor. 相似文献Study selection and data extraction Literature from 2000 to 2008 was identified using MEDLINE and EMBASE, the Cochrane Library and relevant specialist register of the Cochrane Collaboration, and by checking reference lists of known primary studies and review articles. Studies were selected if the accuracy of the fetal ultrasound parameters or Doppler studies of blood flow in the fetal vessels was estimated compared with a reference standard. Data from the selected studies were abstracted as 2 × 2 tables comparing the diagnostic test result with the reference standard. Results were pooled where appropriate. Diagnostic accuracy was expressed as likelihood ratios.
Results Twenty-five primary studies were identified containing suitable data on middle cerebral artery Doppler peak systolic velocity (MCA-PSV). The largest group of studies whose data could be pooled containing nine studies gave a positive likelihood ratio of 4.30 (95% CI: 2.50 to 7.41) and a negative likelihood ratio of 0.30 (95% CI: 0.13 to 0.69) for 675 cases in detecting severe anaemia in the analysis.
Discussion Although middle cerebral artery peak systolic velocity Doppler has limited diagnostic accuracy, it remains the gold standard for noninvasive screening of fetal anaemia. 相似文献
Mangled extremities were classically managed by amputation. But over the past few decades, with the advancement in surgical techniques, an increased number of limb salvages have been possible. As muscles usually get damaged in such grievous injuries, a thorough understanding of muscle regeneration may give a better insight into muscle healing in these injuries. Muscles are composed of slow and fast fibers which can be represented by slow and fast myosin, respectively. There are some animal studies which reported differential regeneration of slow and fast muscle fibers during muscle healing. We conducted this pilot study to find out whether the same holds true for muscle healing in mangled extremities also. This pilot study is designed in 15 patients with lower limb mangled extremities presenting to trauma center of PGIMER, Chandigarh, who were operated within 24 h of injury to see whether muscle healing in mangled extremities follows the same pattern. Biopsies were taken during initial surgery conducted within 24 h of injury and on the 7th day of injury when patient was posted again for secondary wound closure procedure or revision amputation. The biopsy samples were subjected to histopathological and immunohistochemistry examination using antibodies against fast and slow myosin. We found that the regenerating muscle fibers in the biopsy sample taken on the 7th day of injury showed only slow muscle fibers with the absence of fast muscle fibers when compared with the initial biopsy results showing differential regeneration of slow muscle fibers.
相似文献Intertrochanteric fractures are commonly encountered in day-to-day trauma practice having various fracture patterns. Adequate reduction and appropriate fixation methodology is required for optimum results. However, failure rates are very high in unstable fractures. Here we describe a unique unstable variant of intertrochanteric fracture characterized by a long spike of proximal fragment, irreducibility of fracture with standard traction and internal rotation and soft tissue interposition. This appears as typical figure of 3 signs on right side and epsilon ε sign on left side on AP X-ray of pelvis with both hips.
Materials and methodsIn retrospective review of 924 intertrochanteric fractures treated at our institution from June 2005 to January 2017, twenty patients with this typical highly unstable fracture pattern (epsilon sign/figure of 3 at fracture site) were operated at our institution, which included 18 males and two females with average age of 43.5 years (range 30–60 years). All patients required open reduction with specific maneuver and dynamic hip screw fixation.
ResultsAll patients had good reduction at the end of surgery, and all patients had good signs of clinico-radiological union at follow-up. None of the patients had implant loosening or screw back out.
ConclusionThe typical radiological pattern seen on X-ray will guide the surgeon to predict this unstable variant of IT fracture preoperatively and will suggest toward requirement of open reduction with specific maneuver and internal fixation with dynamic hip screw.
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