全文获取类型
收费全文 | 2393095篇 |
免费 | 184812篇 |
国内免费 | 4871篇 |
专业分类
耳鼻咽喉 | 33443篇 |
儿科学 | 79663篇 |
妇产科学 | 69072篇 |
基础医学 | 345356篇 |
口腔科学 | 66622篇 |
临床医学 | 211631篇 |
内科学 | 470203篇 |
皮肤病学 | 53610篇 |
神经病学 | 192114篇 |
特种医学 | 92187篇 |
外国民族医学 | 793篇 |
外科学 | 363339篇 |
综合类 | 54107篇 |
现状与发展 | 4篇 |
一般理论 | 743篇 |
预防医学 | 184604篇 |
眼科学 | 55099篇 |
药学 | 175510篇 |
2篇 | |
中国医学 | 5204篇 |
肿瘤学 | 129472篇 |
出版年
2018年 | 25240篇 |
2017年 | 19157篇 |
2016年 | 21711篇 |
2015年 | 24597篇 |
2014年 | 34458篇 |
2013年 | 51748篇 |
2012年 | 70470篇 |
2011年 | 75105篇 |
2010年 | 44351篇 |
2009年 | 42057篇 |
2008年 | 70769篇 |
2007年 | 75672篇 |
2006年 | 76665篇 |
2005年 | 74599篇 |
2004年 | 71716篇 |
2003年 | 68808篇 |
2002年 | 67191篇 |
2001年 | 113195篇 |
2000年 | 115936篇 |
1999年 | 97339篇 |
1998年 | 27818篇 |
1997年 | 25059篇 |
1996年 | 25176篇 |
1995年 | 23886篇 |
1994年 | 21987篇 |
1993年 | 20664篇 |
1992年 | 75826篇 |
1991年 | 73499篇 |
1990年 | 71626篇 |
1989年 | 69061篇 |
1988年 | 63756篇 |
1987年 | 62506篇 |
1986年 | 58987篇 |
1985年 | 56302篇 |
1984年 | 42509篇 |
1983年 | 36476篇 |
1982年 | 21958篇 |
1981年 | 19522篇 |
1979年 | 38936篇 |
1978年 | 27570篇 |
1977年 | 23277篇 |
1976年 | 22110篇 |
1975年 | 23599篇 |
1974年 | 28081篇 |
1973年 | 27078篇 |
1972年 | 25582篇 |
1971年 | 23542篇 |
1970年 | 22163篇 |
1969年 | 20982篇 |
1968年 | 19728篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
41.
Whitney S. Brandt Wanpu Yan Jian Zhou Kay See Tan Joseph Montecalvo Bernard J. Park Prasad S. Adusumilli James Huang Matthew J. Bott Valerie W. Rusch Daniela Molena William D. Travis Mark G. Kris Jamie E. Chaft David R. Jones 《The Journal of thoracic and cardiovascular surgery》2019,157(2):743-753.e3
Objective
Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non–small cell lung cancer has not been extensively studied.Methods
Patients with cT2-4N0-1M0 non–small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan–Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching.Results
In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response.Conclusions
Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non–small cell lung cancer who undergo complete surgical resection. 相似文献42.
Metabolism describes the series of chemical reactions that are concerned with the provision of energy to biological systems. They may be divided into reactions involved in energy yield (catabolism: demand exceeds supply), and energy storage (anabolism: supply exceeds demand). Regulation of these pathways is critical for homeostasis, and derangements in metabolism are seen in a wide variety of pathological processes. Understanding metabolism is key to the treatment of many diseases, notably diabetes, as well as underpinning clinical nutritional support. 相似文献
43.
44.
45.
46.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study 下载免费PDF全文
47.
Pradeep Balasubramanian M.D. C. R. Srinivas M.D. Pavai Arunachalam M.S. M.Ch. K. S. Thirumurthy M.S. M.Ch. P. R. Rajkumar M.S. M.Ch. H. Manuvidhya M.B.B.S. 《Pediatric dermatology》2015,32(3):e78-e81
We report on a child with several café au lait spots in association with a lumbar lipomeningomyelocele as an apparently new association. Cutaneous markers, the identification of which plays a crucial role in the early diagnosis and management of spinal malformations, can accompany occult spinal dysraphism. Herein we report a case of lumbar lipomeningomyelocele associated with an overlying café au lait spot that served as a marker of occult spinal dysraphism. The patient also had segmental café au lait spots on the face, making the association unique. 相似文献
48.
Nancy C. Lee 《Public health reports (Washington, D.C. : 1974)》2015,130(2):121-Apr;130(2):121
49.
Monique G. Kumar M.Phil. M.D. Heather Ciliberto M.D. Susan J. Bayliss M.D. 《Pediatric dermatology》2015,32(2):198-200
Pediatric trachyonychia is an acquired nail disease that can cause distress to families. It is a poorly understood disease, and long‐term follow‐up data are lacking. We present an institutional review of 11 children with isolated pediatric trachyonychia followed over time. Children with the diagnosis of pediatric trachyonychia were identified and invited to participate. Pictures were taken on follow‐up and a questionnaire was answered. Exclusion criteria include having another diagnosis at the initial visit that causes nail dystrophy. Eleven patients with the diagnosis of pediatric trachyonychia were available for follow‐up. The mean age of appearance was 2.7 years (range 2–7 yrs) and the average follow‐up was 66 months (range 10–126 mos). Nine patients were treated with potent topical corticosteroids, one used only petrolatum, and one took vitamin supplements. One patient was found to have an additional skin and hair diagnosis of alopecia areata on follow‐up. On follow‐up, 82% noted improvement of the nails, whereas 18% noted no change. A majority of cases of pediatric trachyonychia are isolated and improve with time, regardless of treatment. 相似文献
50.
Wojciech Szychta M.D. Ph.D. Gheorghe Cerin M.D. Ph.D. F.E.S.C. Bogdan Adrian Popa M.D. Armienti Felice M.D. Guido Lanzillo M.D. Ph.D. Marco Diena M.D. Grzegorz Opolski M.D. Ph.D. F.E.S.C. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(6):1040-1043
Sinus venosus atrial septal defect (SV‐ASD) usually coexists with partial anomalous pulmonary vein connection (PAPVC). It is a difficult diagnosis in transthoracic echocardiography (TTE) due to eccentric position of defects. We present a rare case of atypical anatomical variation in PAPVC, which was never described before. Two right pulmonary veins drained into superior vena cava, which overrode SV‐ASD and interatrial septum, a third pulmonary vein into the right atrium. Complete diagnosis could not be set after TTE, nor transesophageal echocardiography, whereas angio‐CT was finally conclusive. This diagnostic approach allowed the surgical planning. 相似文献