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71.
P Biron T Philip E Bouffet M C Favrot R Pinkerton M Brunat-Mentigny 《Pathologie-biologie》1987,35(1):97-101
Anthracyclines induced cardiotoxicity in children remains a major problem. Classical data are found: cumulative dose, way of injection, anterior cardiopathy, cardiac area irradiation, interaction with other cytotoxic drugs ad age. 2 kinds of disorders are recorded: 1) Acute rhythmic dysfunctions, early and often transitory; 2) congestive heart failure often not reversible and depending on total dose. Prognostic is still poor and intricate with prognostic of the tumor. Over all incidence is 2.7%. Very young children seem to be more sensitive. Continuous infusion is less toxic than IV bolus. Studies with new anthracyclines are yet uncommon but seems to be comparative with adult literature. Monitoring is identical to adults. EKG is of minor interest. Endomyocardial biopsies have been reported. There is no prognostic value of ultrasound tomogram, but exercise echocardiography can be performed. Nuclide fraction ejection is more reliable. 相似文献
72.
Philip G. Ney 《Canadian Medical Association journal》1991,144(8):956-957
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74.
Apomorphine produced a greater hypothermic response in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats (WKYs). Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermic responsiveness to apomorphine occurs prior to the development of hypertension. The mean systolic blood pressures (SBPs) of SHRs and WKYs were comparable at 4-6 weeks of age. The mean SBP of SHRs were significantly greater than that of WKYs at both 8-10 and 12-15 weeks of age. Yet SHRs responded to apomorphine with significantly greater hypothermia than WKYs at all three ages. These findings indicate that the hyperresponsiveness of SHRs to apomorphine-induced hypothermia precedes the development of hypertension. This sequence of events is consistent with the hypothesis that central DA systems play a role in development of hypertension in SHRs. 相似文献
75.
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77.
Background : The present paper addressed the issue of whether pretreatment with intravenous (IV) chemotherapy affects response rate or survival in patients receiving hepatic artery chemotherapy (HAC). Methods : Case note reviews of 164 patients treated in a teaching hospital from June 1990 to July 1996 were carried out. Results : The response rate and carcino-embryonic antigen (CEA) fall in the two groups was almost identical. There was a nonsignificant survival advantage in the non-pretreatment group. Conclusions : Previous administration of IV chemotherapy did not affect the CEA response of patients receiving HAC. 相似文献
78.
79.
Philip W. H. Peng David T. Wong David Bevan Michael Gardam 《Journal canadien d'anesthésie》2003,50(10):989-997
PURPOSE: To describe the outbreak of severe acute respiratory syndrome (SARS) in Toronto, its impact on anesthesia practice and the infection control guidelines adopted to manage patients in the operating room (OR) and to provide emergency intubation outside the OR. Clinical features: The SARS outbreak in Toronto was the result of a single index patient. The causative virus, SARS-CoV, is moderately contagious, and is spread by droplets and contact. The virus gains access to host through the mucosa of the respiratory tract and the eyes. It can affect both healthy and compromised patients. The use of several precautionary measures such as goggles, gloves, gowns and facemasks and the application of various infection control strategies designed to minimize the spread of the virus are discussed. CONCLUSION: In containing the spread of SARS, vigilance and strict infection control are important. This results in the rediscovery of standards of infection control measures in daily anesthesia practice. 相似文献
80.
Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography 总被引:1,自引:0,他引:1
Matthew R. B. Puncher Philip J. Blower 《European journal of nuclear medicine and molecular imaging》1994,21(12):1347-1365
The understanding of localisation mechanisms and microdosimetry of diagnostic and therapeutic radiopharmaceuticals depends
on knowledge of their biodistribution at the microscopic level (cellular and subcellular) in the target tissues. Various methods
have been advanced for obtaining information about this microdistribution: subcellular fractionation, secondary ion mass spectrometry
imaging, microprobe elemental analysis in the electron microscope, and microautoradiography. This review compares these approaches,
and discusses in detail the methodology of microautoradiography (the most generally useful approach) with imaging and therapy
radionuclides. Literature examples of applications of microautoradiography in nuclear medicine are reviewed, and the future
potential contribution of the techniques is assessed. 相似文献