全文获取类型
收费全文 | 1013篇 |
免费 | 41篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 39篇 |
妇产科学 | 29篇 |
基础医学 | 83篇 |
口腔科学 | 25篇 |
临床医学 | 62篇 |
内科学 | 247篇 |
皮肤病学 | 15篇 |
神经病学 | 53篇 |
特种医学 | 8篇 |
外科学 | 333篇 |
综合类 | 6篇 |
预防医学 | 78篇 |
眼科学 | 6篇 |
药学 | 33篇 |
中国医学 | 8篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 8篇 |
2022年 | 9篇 |
2021年 | 27篇 |
2020年 | 11篇 |
2019年 | 29篇 |
2018年 | 43篇 |
2017年 | 14篇 |
2016年 | 25篇 |
2015年 | 22篇 |
2014年 | 18篇 |
2013年 | 38篇 |
2012年 | 52篇 |
2011年 | 61篇 |
2010年 | 58篇 |
2009年 | 41篇 |
2008年 | 40篇 |
2007年 | 69篇 |
2006年 | 61篇 |
2005年 | 61篇 |
2004年 | 45篇 |
2003年 | 49篇 |
2002年 | 31篇 |
2001年 | 28篇 |
2000年 | 39篇 |
1999年 | 23篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1992年 | 12篇 |
1991年 | 9篇 |
1990年 | 8篇 |
1989年 | 12篇 |
1988年 | 7篇 |
1987年 | 10篇 |
1986年 | 11篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 11篇 |
1977年 | 3篇 |
1974年 | 4篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1969年 | 3篇 |
1968年 | 5篇 |
1967年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有1058条查询结果,搜索用时 15 毫秒
31.
Luján J García De Burgos F Jordán A García M Reyes F Espinosa MD 《Revista espa?ola de cardiología》2002,55(7):764-767
Treatment with 5-fluorouracil is common in oncological patients. Side effects on bone marrow, skin, and mucous membranes have been reported. Cardiotoxicity, which is less predictable, can be life-threatening. Manifestations include angina, arrhythmias, infarction, heart failure and cardiogenic shock. The toxic mechanisms that might be involved have been much discussed but have not yet been clearly established. Current evidence supports the possibility of a metabolic effect in common with the cascade secondary to ischemia due to coronary disease. Based on a case report, we discuss the usual clinical presentation, treatment and prognosis. Finally we make recommendations for managing patients being treated with 5-fluorouracil. 相似文献
32.
33.
Victoria D. Ojeda Amy Eppstein Remedios Lozada Adriana C. Vargas-Ojeda Steffanie A. Strathdee David Goodman Jose L. Burgos 《Journal of immigrant and minority health / Center for Minority Public Health》2014,16(3):546-548
In 2011, a bi-national student-run free clinic for the underserved, known as “Health Frontiers in Tijuana” (HFiT), was created in Tijuana, Mexico. Students and faculty from one Mexican and one US medical school staff the clinic and attend patients on Saturdays. Students from both medical schools enroll in a didactic course during the quarter/semester that they attend the free clinic. The course addresses clinical, ethical, cultural, population-specific issues and the structure, financing and delivery of medical care in Mexico. The clinic implements an electronic medical record and is developing telemedicine for consulting on complex cases. Despite challenges related to sustaining adequate funding, this program may be replicated in other border communities. 相似文献
34.
35.
36.
The distribution of methionine-enkephalin-like cell bodies in the hypothalamus of the cat was studied using an indirect immunoperoxidase technique. Previously, intraventricular or intratissular injections of colchicine were carried out. Met-enkephalin-like neurons were located in all hypothalamic nuclei. The densest clusters of immunoreactive perikarya were observed in the nucleus arcuatus, median eminence, regio praeoptica and perifornical region, whereas the nucleus supraopticus and hypothalamus anterior had the lowest density. In other hypothalamic nuclei the density of methionine-enkephalin (Met-enkephalin) cell bodies was intermediate. 相似文献
37.
38.
S. Cruchaga D'Harcourt A. Buño Soto V. Cascante Burgos D. Lozano Calero R. Martínez-Zapico 《European journal of clinical microbiology & infectious diseases》1996,15(9):749-752
To evaluate enzyme immunoassay (EIA) as an alternative to indirect immunofluorescence assay (IFA) to screen for Q fever in humans, 157 serum samples from patients suspected of having the disease were tested for immunoglobulin G antibodies toCoxiella burnetii. The agreement between the tests and the sensitivity of EIA were excellent (96.8% and 98.4%, respectively) when an IFAtiter of > 1/160 was considered positive. All serum samples with a titer of > 1/320 in the IFA were also positive by the EIA. The EIA seems to be an acceptable alternative to IFA for screening for Q fever. 相似文献
39.
Sabine Delannoy Lothar Beutin Ylanna Burgos Patrick Fach 《Journal of clinical microbiology》2012,50(11):3485-3492
In 2011, a large outbreak of an unusual bacterial strain occurred in Europe. This strain was characterized as a hybrid of an enteroaggregative Escherichia coli (EAEC) and a Shiga toxin-producing E. coli (STEC) strain of the serotype O104:H4. Here, we present a single PCR targeting the clustered regularly interspaced short palindromic repeats locus of E. coli O104:H4 (CRISPRO104:H4) for specific detection of EAEC STEC O104:H4 strains from different geographical locations and time periods. The specificity of the CRISPRO104:H4 PCR was investigated using 1,321 E. coli strains, including reference strains for E. coli O serogroups O1 to O186 and flagellar (H) types H1 to H56. The assay was compared for specificity using PCR assays targeting different O104 antigen-encoding genes (wbwCO104, wzxO104, and wzyO104). The PCR assays reacted with all types of E. coli O104 strains (O104:H2, O104:H4, O104:H7, and O104:H21) and with E. coli O8 and O9 strains carrying the K9 capsular antigen and were therefore not specific for detection of the EAEC STEC O104:H4 type. A single PCR developed for the CRISPRO104:H4 target was sufficient for specific identification and detection of the 48 tested EAEC STEC O104:H4 strains. The 35 E. coli O104 strains expressing H types other than H4 as well as 8 E. coli strains carrying a K9 capsular antigen tested all negative for the CRISPRO104:H4 locus. Only 12 (0.94%) of the 1,273 non-O104:H4 E. coli strains (serotypes Ont:H2, O43:H2, O141:H2, and O174:H2) reacted positive in the CRISPRO104:H4 PCR (99.06% specificity). 相似文献
40.
María De Los Ángeles Monclus Andreína Cesari María Eugenia Cabrillana Paola Vanina Borelli Amanda Edith Vincenti Mario Héctor Burgos Miguel Walter Fornés 《Anatomical record (Hoboken, N.J. : 2007)》2007,290(7):814-824
In many mammals, sperm associations had been observed, but not in the mouse. In this work, mouse sperm rosettes are morphologically described inside the epididymis and during its dissolution in a culture medium. Also characterized are the saccharides present in the linking material. Sperm association and other epididymal actions are supported by sperm during epididymal transit and are verified at the caudal region, suggesting a relation between epididymal transit and sperm maturation. In drops of epididymal content obtained from distal (cauda), but not from proximal (caput and corpus) regions; dissolved in culture medium, rosettes appear to be 10 to 15 motile sperm joined by their heads. After 3 min, sperm progressively detach, disassembling the rosette. These structures are studied by several techniques, including optic, electronic (scanning electron microscopy and transmission electron microscopy), and video microscopy. At the ultrastructural level, a dense network of electron‐dense material was observed between sperm heads, joining them. Based on previous works in rat, several lectins were used to characterize the type of saccharides present in this linking material. To avoid the contact between sperm and epididymal fluid from distal region—that probably exerts an influence on sperm association—a ligature was placed between caput and corpus. This epididymal content isolated from caput did not display any rosettes after 28 days. Anat Rec, 2007. © 2007 Wiley‐Liss, Inc. 相似文献