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排序方式: 共有917条查询结果,搜索用时 453 毫秒
911.
Camous Moslemi Susanne G. Sækmose Rune Larsen Jakob T. Bay Thorsten Brodersen Maria Didriksen Henrik Hjalgrim Karina Banasik Kaspar R. Nielsen Mie T. Bruun Joseph Dowsett Khoa M. Dinh Susan Mikkelsen Christina Mikkelsen Thomas F. Hansen Henrik Ullum Christian Erikstrup Søren Brunak Karen Angeliki Krogfelt Jill R. Storry Sisse R. Ostrowski Martin L. Olsson Ole B. Pedersen 《Transfusion》2023,63(12):2297-2310
912.
913.
Louise Ørnskov Drechsler Jens Kjærgaard Boldsen Lotte Hindhede Bitten Aagaard Lene Holm Harritshøj Christina Mikkelsen Thorsten Brodersen Nanna Brøns Michael Schwinn Henrik Hjalgrim Klaus Rostgaard Mie Topholm Bruun Sisse Rye Ostrowski Ole Birger Pedersen Susan Mikkelsen Christian Erikstrup 《Transfusion》2023,63(9):1710-1718
Background
The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark.Study Design and Methods
We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period.Results
We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71–0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02–1.08.Discussion
Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor. 相似文献914.
915.
916.
Hayder Alhusseinawi Lotte Sander Pernille M. Rosenvinge Sarah L. Jensen Niels Henrik Bruun Pernille S. Kingo Jørgen B. Jensen Sten Rasmussen 《BJU international》2023,132(5):560-567
Objective
To investigate the effectiveness and impact of low-pressure pneumoperitoneum (Pnp) on postoperative quality of recovery (QoR) and surgical workspace (SWS) in patients with prostate cancer undergoing robot-assisted radical prostatectomy (RARP).Patients and Methods
A randomised, triple-blinded trial was conducted in a single centre in Denmark from March 2021 to January 2022. A total of 98 patients with prostate cancer undergoing RARP were randomly assigned to either low-pressure Pnp (7 mmHg) or standard-pressure Pnp (12 mmHg). Co-primary outcomes were postoperative QoR measured via the QoR-15 questionnaire on postoperative Day 1 (POD1), POD3, POD14, and POD30, and SWS assessed intraoperatively by a blinded assessor (surgeon) via a validated SWS scale. Data analysis was performed according to the intention-to-treat principle.Results
Patients who underwent RARP at low Pnp pressure demonstrated better postoperative QoR on POD1 (mean difference = 10, 95% confidence interval [CI] 4.4–15.5), but no significant differences were observed in the SWS (mean difference = 0.25, 95% CI −0.02 to 0.54). Patients allocated to low-pressure Pnp experienced statistically higher blood loss than those in the standard-pressure Pnp group (mean difference = 67 mL, P = 0.01). Domain analysis revealed significant improvements in pain (P = 0.001), physical comfort (P = 0.007), and emotional state (P = 0.006) for patients with low-pressure Pnp. This trial was registered at ClinicalTrials.gov , NCT04755452, on 16/02/2021.Conclusion
Performing RARP at low Pnp pressure is feasible without compromising the SWS and improves postoperative QoR, including pain, physical comfort, and emotional state, compared to the standard pressure. 相似文献917.
Camous Moslemi Susanne Sækmose Rune Larsen Thorsten Brodersen Maria Didriksen Henrik Hjalgrim Karina Banasik Kaspar R. Nielsen Mie T. Bruun Joseph Dowsett Kathrine A. Kasperen Susan Mikkelsen Thomas F. Hansen Henrik Ullum Christian Erikstrup Martin L. Olsson Sisse R. Ostrowski Ole B. Pedersen 《Transfusion》2023,63(1):47-58