全文获取类型
收费全文 | 112879篇 |
免费 | 5907篇 |
国内免费 | 524篇 |
专业分类
耳鼻咽喉 | 1318篇 |
儿科学 | 3012篇 |
妇产科学 | 2515篇 |
基础医学 | 15698篇 |
口腔科学 | 2445篇 |
临床医学 | 9220篇 |
内科学 | 27864篇 |
皮肤病学 | 2252篇 |
神经病学 | 10417篇 |
特种医学 | 3745篇 |
外国民族医学 | 32篇 |
外科学 | 14496篇 |
综合类 | 467篇 |
一般理论 | 26篇 |
预防医学 | 9258篇 |
眼科学 | 1833篇 |
药学 | 7751篇 |
中国医学 | 314篇 |
肿瘤学 | 6647篇 |
出版年
2023年 | 672篇 |
2022年 | 1309篇 |
2021年 | 2839篇 |
2020年 | 1565篇 |
2019年 | 2495篇 |
2018年 | 4725篇 |
2017年 | 3028篇 |
2016年 | 2475篇 |
2015年 | 2697篇 |
2014年 | 3535篇 |
2013年 | 4871篇 |
2012年 | 7532篇 |
2011年 | 7638篇 |
2010年 | 4166篇 |
2009年 | 3636篇 |
2008年 | 6446篇 |
2007年 | 6647篇 |
2006年 | 6207篇 |
2005年 | 6309篇 |
2004年 | 5934篇 |
2003年 | 5505篇 |
2002年 | 5264篇 |
2001年 | 2552篇 |
2000年 | 2677篇 |
1999年 | 2239篇 |
1998年 | 893篇 |
1997年 | 614篇 |
1996年 | 565篇 |
1995年 | 506篇 |
1994年 | 444篇 |
1993年 | 410篇 |
1992年 | 1200篇 |
1991年 | 996篇 |
1990年 | 985篇 |
1989年 | 879篇 |
1988年 | 782篇 |
1987年 | 798篇 |
1986年 | 709篇 |
1985年 | 642篇 |
1984年 | 482篇 |
1983年 | 387篇 |
1982年 | 251篇 |
1979年 | 326篇 |
1978年 | 249篇 |
1974年 | 259篇 |
1973年 | 266篇 |
1972年 | 251篇 |
1971年 | 248篇 |
1970年 | 223篇 |
1968年 | 222篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Dominique Trudel Luminita-Mihaela Avarvarei Michèle Orain Stéphane Turcotte Marie Plante Jean Grégoire Reinhild Kappelhoff David P. Labbé Dimcho Bachvarov Bernard Têtu Christopher M. Overall Isabelle Bairati 《Pathology, research and practice》2019,215(6):152369
Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. A targeted DNA microarray known as the CLIP-CHIP microarray was used to identify potential prognostic factors in ten high-grade serous ovarian cancer women who had early recurrence (<1.6 years) or late/no recurrence after first line surgery and chemotherapy. In women with early recurrence, we identified seven upregulated genes (TMPRSS4, MASP1/3, SPC18, PSMB1, IGFBP2, CFI – encoding Complement Factor I – and MMP9) and one down-regulated gene (ADAM-10). Using immunohistochemistry, we evaluated the prognostic effect of these 8 candidate genes in an independent cohort of 112 high-grade serous ovarian cancer women. Outcomes were progression, defined according to CA-125 criteria, and death. Multivariate Cox proportional hazard regression models were done to estimate the associations between each protein and each outcome. High ADAM-10 expression (intensity of 2–3) was associated with a lower risk of progression (adjusted hazard ratio (HR): 0.51; 95% confidence interval (CI): 0.29-0.87). High complement factor I expression (intensity 2–3) was associated with a higher risk of progression (adjusted HR: 2.30, 95% CI: 1.17–4.53) and death (adjusted HR: 3.42; 95% CI: 1.72–6.79). Overall, we identified the prognostic value of two proteases, ADAM-10 and complement factor I, for high-grade serous ovarian cancer which could have clinical significance. 相似文献
22.
23.
Maria Russo Claudio Lucifora Francesco Pucciarelli Bruno Piccoli 《La Medicina del lavoro》2019,110(2):115
Background:Workplace hazards are a significant source of health impairment for workers and of financial losses for firms. EU directives on workers’ health and safety standards significantly contributed to reduce reported occupational injuries, yet the incidence and prevalence of work-related mental illness is still very high.Objectives:We investigated the association between work-related hazards and individuals’ perceived mental health. We reviewed the existing evidence on the channels through which task-related factors, adverse agents and psychosocial factors are expected to affect workers’ health, with specific regard to mental health.Methods:We used data from the fifth wave of the European Working Conditions Survey, covering over 40,000 face-to-face interviews with workers in 34 countries, which includes information on socio-demographic characteristics, firms and jobs attributes, employment status, as well as working conditions and health status. We carried out an empirical analysis with multivariate regression models in order to estimate the relationship between workers’ mental health problems and workplace risk factors.Results:21,020 interviews were used in the multivariate analysis. We found strong correlations between hazards and various indicators of mental health. Among hazardous agents, low temperatures (β=0.0287) and contact with infectious materials (β=0.0394) were positively associated with mental health outcomes. Among task/sequence-related factors, tiring or painful positions (β=0.0713), repetitive hand/arm movements (β=0.0255), working with VDUs (β=0.0301), repetitive tasks <10 min (β=0.0859) and working in evenings (β=0.00754) were positively associated with mental health. Various psychosocial risk factors related to both the content of the job (for example, frequent disruptive interruptions: β=0.219, working in free time: β=0.0759, poor work-life balance: β=0.228) as well as the job context (for example, bad employment prospects: β=0.177, low decisional autonomy: β=0.245, bad social relations: β=0.186, workplace violence: β=0.411) were positively associated with mental health. The main results of the decomposition show that an important contribution to workers’ overall mental distress at work is associated with psychosocial risk factors (up to 60% for depression/anxiety symptoms and sleep disorders), while the contribution of somatic factors is on average lower (up to 20% for overall fatigue).Conclusions:We argue that action is needed to improve workers’ mental well-being, and reduce the economic costs for both the national health system and employers. Regulations and traditional economic measures are unlikely to prove successful in providing adequate standards of primary and secondary preventive measures in the work place without an appropriate and reliable Risk Assessment Procedure.Key words: Work hazards, risk assessment, job content, mental health 相似文献
24.
25.
Marion Tardieu Najat Salameh Line Souris David Rousseau Laurène Jourdain Hanadi Skeif François Prévot Ludovic de Rochefort Denis Ducreux Bruno Louis Philippe Garteiser Ralph Sinkus Luc Darrasse Marie Poirier-Quinot Xavier Maître 《NMR in biomedicine》2022,35(7):e4701
Magnetic resonance elastography aims to non-invasively and remotely characterize the mechanical properties of living tissues. To quantitatively and regionally map the shear viscoelastic moduli in vivo, the technique must achieve proper mechanical excitation throughout the targeted tissues. Although it is straightforward, ante manibus, in close organs such as the liver or the breast, which practitioners clinically palpate already, it is somewhat fortunately highly challenging to trick the natural protective barriers of remote organs such as the brain. So far, mechanical waves have been induced in the latter by shaking the surrounding cranial bones. Here, the skull was circumvented by guiding pressure waves inside the subject's buccal cavity so mechanical waves could propagate from within through the brainstem up to the brain. Repeatable, reproducible and robust displacement fields were recorded in phantoms and in vivo by magnetic resonance elastography with guided pressure waves such that quantitative mechanical outcomes were extracted in the human brain. 相似文献
26.
Del Lama Rafael Silva Candido Raquel Mariana Chiari-Correia Natália Santana Nogueira-Barbosa Marcello Henrique de Azevedo-Marques Paulo Mazzoncini Tinós Renato 《Journal of digital imaging》2022,35(3):446-458
Journal of Digital Imaging - Vertebral Compression Fracture (VCF) occurs when the vertebral body partially collapses under the action of compressive forces. Non-traumatic VCFs can be secondary to... 相似文献
27.
28.
29.
30.
Ángela M. Ortega-Galán M. Dolores Ruiz-Fernández Rocío Ortiz-Amo José Cabrera-Troya Inés M. Carmona-Rega Olivia Ibáñez-Masero 《Enfermería clínica》2019,29(1):10-17