全文获取类型
收费全文 | 42876篇 |
免费 | 2567篇 |
国内免费 | 274篇 |
专业分类
耳鼻咽喉 | 494篇 |
儿科学 | 839篇 |
妇产科学 | 835篇 |
基础医学 | 5875篇 |
口腔科学 | 2380篇 |
临床医学 | 3603篇 |
内科学 | 10076篇 |
皮肤病学 | 768篇 |
神经病学 | 3875篇 |
特种医学 | 1166篇 |
外国民族医学 | 1篇 |
外科学 | 5602篇 |
综合类 | 205篇 |
一般理论 | 12篇 |
预防医学 | 3361篇 |
眼科学 | 640篇 |
药学 | 3555篇 |
中国医学 | 245篇 |
肿瘤学 | 2185篇 |
出版年
2023年 | 310篇 |
2022年 | 751篇 |
2021年 | 1331篇 |
2020年 | 863篇 |
2019年 | 1132篇 |
2018年 | 1422篇 |
2017年 | 1027篇 |
2016年 | 1131篇 |
2015年 | 1308篇 |
2014年 | 1661篇 |
2013年 | 2134篇 |
2012年 | 3176篇 |
2011年 | 3309篇 |
2010年 | 1800篇 |
2009年 | 1599篇 |
2008年 | 2563篇 |
2007年 | 2595篇 |
2006年 | 2280篇 |
2005年 | 2237篇 |
2004年 | 1976篇 |
2003年 | 1773篇 |
2002年 | 1639篇 |
2001年 | 759篇 |
2000年 | 726篇 |
1999年 | 654篇 |
1998年 | 367篇 |
1997年 | 274篇 |
1996年 | 219篇 |
1995年 | 213篇 |
1994年 | 186篇 |
1993年 | 179篇 |
1992年 | 394篇 |
1991年 | 326篇 |
1990年 | 300篇 |
1989年 | 243篇 |
1988年 | 238篇 |
1987年 | 181篇 |
1986年 | 202篇 |
1985年 | 174篇 |
1984年 | 151篇 |
1983年 | 115篇 |
1982年 | 100篇 |
1981年 | 81篇 |
1980年 | 93篇 |
1979年 | 127篇 |
1978年 | 72篇 |
1977年 | 74篇 |
1975年 | 74篇 |
1974年 | 81篇 |
1973年 | 82篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Susannah V Quisling Vinay A Shah Ho K Lee Bruno Policeni Wendy R K Smoker Coleman Martin Andrew G Lee 《Journal of neuro-ophthalmology》2006,26(1):47-48
A 44-year-old man with right-sided herpes zoster ophthalmicus (HZO) developed ipsilateral third and sixth cranial nerve palsies and first-division trigeminal (fifth cranial nerve) sensory loss. MRI revealed contrast enhancement of the cisternal and cavernous portions of the third cranial nerve and high signal on a FLAIR sequence within the ipsilateral medulla at the presumed location of the trigeminal nucleus and tract. To our knowledge, this is the first report of the combination of these imaging findings in HZO. 相似文献
72.
Daniel B. Costa Christopher A. Fisher Kenneth B. Miller German A. Pihan David P. Steensma Richard J. Gibbons Douglas R. Higgs 《European journal of haematology》2006,76(5):432-435
Abstract: We describe a patient with acquired alpha-thalassemia myelodysplastic syndrome (ATMDS). A previously healthy 66-year-old man presented with hemoglobin of 9.3 g/dL, mean corpuscular volume 59 fL, and a bone marrow aspirate with increased erythroid precursors and hypolobulated megakaryocytes. Hemoglobin H inclusions were seen in most red cells after 1% brilliant cresyl blue supravital stain of the peripheral blood. At the molecular level, we identified of a novel mutation in the most 3' exon of the ATRX gene ( C GA→ T GA substitution in codon 2407) resulting in a premature termination codon (p.R2407X). This case provides further evidence for a link between ATRX mutations and ATMDS, and suggests a possible role for the conserved Q-box element in ATRX function. 相似文献
73.
Severe hemorrhagic radiation proctitis advancing to gradual cessation with hyperbaric oxygen 总被引:3,自引:0,他引:3
Dr. Jacky Charneau MD Gilles Bouachour MD Bruno Person MD Pascal Burtin MD Jean Ronceray MD Jean Boyer MD 《Digestive diseases and sciences》1991,36(3):373-375
Summary We report a case of a male patient suffering from a severe hemorrhagic radiation proctitis which gradually ceased with hyperbaric oxygen. We discuss the mechanisms of chronic radiation injury and the effect of the hyperbaric oxygen. This therapy is proposed as an alternative to surgical intervention for this abnormality. 相似文献
74.
Paolo Martinelli Giovanni Rizzo David Manners Caterina Tonon Fabio Pizza Claudia Testa Cesa Scaglione Bruno Barbiroli Raffaele Lodi 《Movement disorders》2007,22(8):1182-1185
The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and (1)H-MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion-weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out. 相似文献
75.
Abstract The outcome of OLT for HBV-related liver disease is dependent on the prevention of allograft re-infection. Over the past decade, major advances have been made in the management of HBV transplant candidates. The advent of long-term hepatitis B immune globulin (HBIG) administration as a prophylaxis against HBV recurrence, and the introduction of new antiviral agents against HBV infection, such as lamivudine (LAM), were a major breakthrough in the management of these patients. Results of OLT for HBV infection are similar to those achieved with other indications. Pre-OLT antiviral treatment such as LAM can suppress HBV replication before OLT and thus decrease the risk of re-infection of the graft. Combination prophylaxis with LAM and HBIG after transplantation highly effectively reduces the rate of HBV re-infection, even in HBV replicative cirrhotic, patients. The optimal HBIG protocol in the LAM era is yet to be defined: dosing of HBIG, routes of administration, and possibility of stopping HBIG. Several antiviral drugs have been developed for the management of HBV infection on the graft, so outcome is currently good. 相似文献
76.
77.
78.
Humberto Morais Luísa Moura Branco Rosa Cunha Telmo Martins 《Revista portuguesa de cardiologia》2007,26(4):367-372
Submitral ventricular aneurysm is a thoroughly studied pathology but is not well known due to its rarity. Clinically, it is manifested by symptoms and signs of heart failure, mitral regurgitation and/or ventricular arrhythmias, and may be associated with thromboembolic phenomena and myocardial ischemia due to compression of the coronary arteries by the aneurysm. A rare complication of this type of aneurysm is rupture into the left atrium. Transthoracic echocardiography plays an important role in the definitive diagnosis of this pathology, although the role of transesophageal echocardiography in the evaluation of these patients is less known. We report a case of a submitral ventricular aneurysm complicated by rupture into the left atrium, which was diagnosed by transesophageal echocardiography. 相似文献
79.
L Bonina M Carbone P Mastroeni G B Costa P Mastroeni 《Journal of chemotherapy (Florence, Italy)》1992,4(6):353-357
This study was undertaken to investigate the efficacy of rufloxacin, a new quinolone which is interesting due to its pharmacokinetics characterized by a long plasma half-life, in the treatment of systemic salmonella infections in the mouse typhoid model. Innately susceptible BALB/c and resistant CBA mice were used to investigate the efficacy of rufloxacin in controlling systemic salmonella infections when given for brief or prolonged periods. The present study shows that rufloxacin is not only very effective on both mouse strains, but can completely eradicate the salmonellae from livers and spleens when given early in the infection of CBA resistant mice. 相似文献
80.
Antinori Andrea Cingolani Antonella Lorenzini Patrizia Giancola Maria Letizia Uccella Ilaria Bossolasco Simona Grisetti Susanna Moretti Francesca Vigo Beniamino Bongiovanni Marco Del Grosso Bruno Arcidiacono Maria Irene Fibbia Giovanni Carlo Mena Maurizio Finazzi Maria Grazia Guaraldi Giovanni Ammassari Adriana Monforte Antonella dArminio Cinque Paola De Luca Andrea 《Journal of neurovirology》2003,9(1):47-53
Human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML) remains a relevant clinical problem even in the era of highly active antiretroviral therapy (HAART). Aims of the study were to analyze clinical and treatment-related features and the survival probability of PML patients observed within the Italian Registry Investigative Neuro AIDS (IRINA) during a 29-month period of HAART. Intravenous drug use, the presence of focal signs, and the involvement of white matter at neuroradiology increased the risk of having PML. A reduced probability of PML was observed when meningeal signs were reported. Patients starting HAART at PML diagnosis and previously naïve for antiretrovirals showed significantly higher 1-year probability of survival (.58), compared to those continuing HAART (.24), or never receiving HAART (.00). Higher CD4 cell count were associated with a higher survival probability (.45). At multivariate analysis, a younger age, higher CD4, starting HAART at PML diagnosis, the absence of previous acquired immunodeficiency syndrome (AIDS)-defining events, and the absence of a severe neurologic impairment were all associated with a reduced hazard of death. The use of cidofovir showed a trend towards a reduced risk of death. 相似文献