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971.
972.
Guillaume?Passot Bruno?C.?Odisio Daria?Zorzi Armeen?Mahvash Sanjay?Gupta Michael?J.?Wallace Bradford?J.?Kim Suguru?Yamashita Claudius?Conrad Thomas?A.?Aloia Jean-Nicolas?Vauthey Yun?Shin?ChunEmail author 《Journal of gastrointestinal surgery》2016,20(6):1173-1178
Background
The risk of colorectal liver metastases (CLM) disappearing on cross-sectional imaging has increased with advances in preoperative chemotherapy, but <50 % of disappearing CLM demonstrate complete pathological response.Objective
The aim of this study was to evaluate the role of fiducial marker placement before potentially curative treatment of CLM at risk of disappearing with chemotherapy.Methods
All consecutive patients who underwent fiducial placement for tracking of CLM at a tertiary center were reviewed.Results
Among 1377 patients undergoing CLM resection between 2005 and 2015, 35 patients underwent fiducial placement. Three patients were excluded due to disease progression. The study population comprised 32 patients who underwent fiducial placement in 41 CLM. Among the 41 marked CLM, 34 (83 %) were located >10 mm deep in the liver parenchyma, 25 (61 %) were in the right liver, and median size was 12 mm (range, 6–20 mm). No complication occurred after fiducial placement. After chemotherapy, 19 (46 %) of the 41 marked metastases disappeared on cross-sectional imaging. All fiducial-tracked CLM were treated with resection (n?=?31) or ablation (n?=?10). After median follow-up of 14 months (range, 0–64 months), no local recurrences were observed.Conclusion
Fiducial placement represents a safe procedure that facilitates accurate localization for resection or ablation of small CLM at risk of disappearing with chemotherapy.973.
974.
The role of lymph node revealing solution on the improvement of lymph node harvest in colorectal cancer specimens 下载免费PDF全文
975.
Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody–Mediated Operational Tolerance Induction 下载免费PDF全文
D. Calderon M. Prot S. You C. Marquet V. Bellamy P. Bruneval F. Valette P. de Almeida J. C. Wu M. Pucéat P. Menasché L. Chatenoud 《American journal of transplantation》2016,16(2):454-467
Implantation of embryonic stem cells (ESCs) and their differentiated derivatives into allogeneic hosts triggers an immune response that represents a hurdle to clinical application. We established in autoimmunity and in transplantation that CD3 antibody therapy induces a state of immune tolerance. Promising results have been obtained with CD3 antibodies in the clinic. In this study, we tested whether this strategy can prolong the survival of undifferentiated ESCs and their differentiated derivatives in histoincompatible hosts. Recipients of either mouse ESC–derived embryoid bodies (EBs) or cardiac progenitors received a single short tolerogenic regimen of CD3 antibody. In immunocompetent mice, allogeneic EBs and cardiac progenitors were rejected within 20–25 days. Recipients treated with CD3 antibody showed long‐term survival of implanted cardiac progenitors or EBs. In due course, EBs became teratomas, the growth of which was self‐limited. Regulatory CD4+FoxP3+ T cells and signaling through the PD1/PDL1 pathway played key roles in the CD3 antibody therapeutic effect. Gene profiling emphasized the importance of TGF‐β and the inhibitory T cell coreceptor Tim3 to the observed effect. These results demonstrate that CD3 antibody administered alone promotes prolonged survival of allogeneic ESC derivatives and thus could prove useful for enhancing cell engraftment in the absence of chronic immunosuppression. 相似文献
976.
Charles Dzviga Catherine Matevi Philippe Bonniaud Fran?ois Lavaud Bruno Girodet Joelle Birnbaum Claude Lambert the Interest Group on Insect Venom Hypersensitivity Allergy from the French Society of Allergology French Federation of Continuous Medical Education in Allergology 《Archives of Medical Science》2016,12(1):150-155
Introduction
Venom immunotherapy (VIT) is the only efficient prevention for sting-induced anaphylaxis, but its application is not without risks and needs precautions and standardization. European guidelines were proposed in 2005, but recent practice surveys and more recent knowledge raise the need for an update. The aim of this study was to analyze VIT practices in France, based on previous surveys in Europe but also extended to outcome event management.Material and methods
A paper questionnaire was sent widely to persons involved in venom treatment.Results
Eighty-six responses could be included from physicians actively involved in VIT induction evenly distributed in France. The survey shows that VIT was engaged from grade III down to grade I reactions, starting preferentially with the ultra-rush protocol. Premedication was used by 42% only and risks induced by co-treatment with β-blockers were well known but not with angiotensin-converting enzyme inhibitors. However, side effects were very variably managed from arrest to enhancement in doses, time-delay or duration. Similarly, we observed a large discrepancy in treatment evaluation (skin tests, biology, timing and interpretation), decision making for treatment termination (when and how long to be prolonged) and post-treatment follow-up (adrenaline kit, event record) as well as procedures in case of late relapse (new induction, different doses).Conclusions
Our study shows that most recommendations were fully or partially followed and may need reminding, but many points need to be completed or updated with new tools and knowledge acquired during the last 10 years. 相似文献977.
Maria Elisabeth Moreira Ana Paula Esteves Pereira Saint Clair Gomes Junior Ruth Guinsburg Maria Fernanda Branco de Almeida Silvana Granado Gama Maria do Carmo Leal 《Reproductive health》2016,13(3):116
Background
Approximately 5–10 % of newborns require some form of resuscitationupon delivery; several factors, such as maternal abnormal conditions, gestational age and type of delivery could be responsible for this trend. This study aimed to describe the factors associated with the need for positive pressure ventilation (PPV) via a mask or endotracheal tube and the use of supplemental O2 in newborns with a gestational age greater than 34 weeks in Brazil.Methods
We performed a cross-sectional study and obtained data from the Birth in Brazil Survey. The inclusion criterion was a gestational age ≥34 weeks. Exclusion criteria were newborns with congenital malformations, and cases with undetermined gestational age or type of delivery (vaginal, pre labor cesarean section and cesarean section during labor). The primary outcomes were need of PPV via a mask or endotracheal tube and the use of supplemental oxygen without PPV. Confounding variables, including maternal age, source of birth payment, years of maternal schooling, previous birth, newborn presentation, multiple pregnancy, and maternal obstetric risk, were analyzed.Results
We included 22,720 newborns. Of these, 2974 (13.1 %) required supplementary oxygen. PPV with a bag and mask was used for 727 (3.2 %) newborns and tracheal intubation for 192 (0.8 %) newborns. Chest compression was necessary for 136 (0.6 %) newborns and drugs administered in 114 (0.5 %). 51.3 % of newborns were delivered by cesarean section, with the majority of cesarean sections (88.7 %) being performed prior to labor. Gestational age (late preterm infants: (Relative Risk-(RR) 2.46; 95 % (Confidence interval-CI 1.79–3.39), maternal obstetric risk (RR 1.59; 95 % CI1.30–1.94), and maternal age of 12–19 years old (RR 1.36; 95 % CI1.06–1.74) contributed to rates of PPV in the logistic regression analysis. Newborns aged between 37–38 weeks of gestaional age weren´t less likely to require PPV compared with those aged 39–41 weeks of gestational age.Conclusions
Late preterm infants, previous maternal obstetric risks and maternal age contributed to the higher needs of PPV and use of O2 in the delivery room. These variables need to be considered in planning care in the delivery room.978.
979.
Samip N. Patel MD Marc A. Cohen MD Babak Givi MD Benjamin J. Dixon MD Ralph W. Gilbert MD Patrick J. Gullane MD Dale H. Brown MD Jonathan C. Irish MSc MD John R. de Almeida MSc MD Kevin M. Higgins MSc Danny Enepekides MSc Shao Hui Huang John Waldron MD Brian O'Sullivan MD Wei Xu PhD Susie Su MSc David P. Goldstein MSc MD 《Head & neck》2016,38(Z1):E658-E664
980.
Impact of p16 expression,nodal status,and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma 下载免费PDF全文