全文获取类型
收费全文 | 1036篇 |
免费 | 68篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 35篇 |
妇产科学 | 30篇 |
基础医学 | 112篇 |
口腔科学 | 26篇 |
临床医学 | 71篇 |
内科学 | 184篇 |
皮肤病学 | 17篇 |
神经病学 | 178篇 |
特种医学 | 106篇 |
外科学 | 110篇 |
综合类 | 52篇 |
预防医学 | 70篇 |
眼科学 | 21篇 |
药学 | 35篇 |
肿瘤学 | 51篇 |
出版年
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 15篇 |
2017年 | 9篇 |
2016年 | 12篇 |
2015年 | 19篇 |
2014年 | 21篇 |
2013年 | 41篇 |
2012年 | 40篇 |
2011年 | 43篇 |
2010年 | 44篇 |
2009年 | 36篇 |
2008年 | 36篇 |
2007年 | 36篇 |
2006年 | 55篇 |
2005年 | 38篇 |
2004年 | 56篇 |
2003年 | 37篇 |
2002年 | 33篇 |
2001年 | 24篇 |
2000年 | 26篇 |
1999年 | 25篇 |
1998年 | 39篇 |
1997年 | 30篇 |
1996年 | 33篇 |
1995年 | 37篇 |
1994年 | 22篇 |
1993年 | 8篇 |
1992年 | 18篇 |
1991年 | 11篇 |
1990年 | 20篇 |
1989年 | 29篇 |
1988年 | 20篇 |
1987年 | 21篇 |
1986年 | 26篇 |
1985年 | 11篇 |
1984年 | 14篇 |
1983年 | 13篇 |
1982年 | 5篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1969年 | 3篇 |
1967年 | 9篇 |
1966年 | 9篇 |
排序方式: 共有1112条查询结果,搜索用时 0 毫秒
61.
Background
The present study was conducted to study the efficacy and toxicity profile of methotrexate chloroquine combination in treatment of active rheumatoid arthritis.Methods
24 patients of rheumatoid arthritis confirming to revised American Rheumatism Association (ARA) criteria were studied prospectively for twenty months. Clinical evaluation was made every 3 months. Clinical disease variables measured at each visit were number of joints with swelling, number of joints with tenderness and pain, duration of morning stiffness and physician and patient assessment of disease activity. Blood counts, liver function tests and other adverse effects due to drugs were monitored every 2 months.Results
10 patients demonstrated more than 50% improvement. 4 patients withdrew from study, 2 because of excessive nausea and vomiting and 2 because of noncompliance. Other side effects noted were hyperpigmentation, photosensitivity, skin rashes, raised transaminases and stomatitis.Conclusion
Methotrexate chloroquine combination has good efficacy and toxicity profile. Gastrointestinal side effects are most common and usually responsible for the discontinuation of the drugs.Key Words: Rheumatoid arthritis, Methotrexate, Chloroquine, Efficacy, Toxicity 相似文献62.
Although social work participation on interdisciplinary teams is long-standing, little research has been done to examine its effectiveness. This study used the Index of Interdisciplinary Collaboration to explore relationships between selected variables and teamwork in the hospice setting.The findings indicate that hospice social workers report a high level of interdisciplinary collaboration with colleagues. Whereas education, hospice census, the presence of other social workers, and quality of care were found to be unrelated to overall levels of collaboration, individual items measuring collaboration proved to be linked with hospice census, the presence of other social workers on the team, and quality of care. Further research is required to investigate other possible related variables and their impact on successful interdisciplinary collaboration and service delivery. 相似文献
63.
Fedoruk MJ Bronstein R Kerger BD 《Journal of exposure analysis and environmental epidemiology》2005,15(6):534-544
There is scant information pertaining to airborne ammonia exposures from either spills or common household uses of ammonia-containing floor and tile cleaners or from spray-on glass cleaners. We assessed instantaneous and event-specific time-weighted average (TWA) exposures to airborne ammonia during spills and use (per label directions) of a household floor and tile cleaner and two spray-on window cleaners. Airborne ammonia levels measured at breathing zone height (BZH) above the spilled floor and tile cleaner product reached 500 p.p.m. within 5 min, while levels for spilled window cleaner were below 8 p.p.m. TWA exposures were assessed while tile walls and floors were cleaned in three different bathrooms of a residence, and during use of a spray-on glass cleaner while washing several large windows in an office setting. NIOSH Method 6015 was utilized with concurrent field measurements every 60 s using a Drager PAC III monitor with an electrochemical cell detector. Peak ammonia levels ranged from 16 to 28 p.p.m. and short-term TWA concentrations ranged from 9.4 to 13 p.p.m. during mixing (0.1% ammonia) and cleaning tiles in the three bathrooms. Ammonia exposures while using spray-on window cleaner were over 10-fold lower (TWA=0.65 p.p.m.). Use of the floor and tile cleaner mixed at 0.2% ammonia led to peak airborne ammonia levels within 3-5 min at 36-90 p.p.m., and use of full strength cleaner (3% ammonia) led to peak ammonia levels of 125 to >200 p.p.m. within 2-3 min. Spillage or intentional use of the full strength floor and tile cleaner led to airborne ammonia concentrations that exceed occupational short-term exposure limits, while spillage or use of the spray-on window cleaner did not approach potentially hazardous airborne ammonia levels and likely represents a minimal inhalation health hazard. We conclude that routine household uses of ammonia are unlikely to produce significant exposures when using standard cleaning solutions (0.1-0.2%), but spillage or use of concentrated ammonia solutions (e.g., 3%) in poorly ventilated areas can lead to potentially hazardous airborne ammonia exposures. 相似文献
64.
Bronstein DE Cotliar J Votava-Smith JK Powell MZ Miller MJ Cherry JD 《The Pediatric infectious disease journal》2005,24(3):269-270
Varicella-like rash after immunization with the live attenuated varicella vaccine is relatively common. Such vaccine-associated rashes generally consist of fewer lesions than occur in chickenpox. We describe a 15-month-old girl who experienced the onset of recurring papular urticaria after varicella immunization. The rash was varicella-like and thought by us to be caused by vaccine virus. 相似文献
65.
66.
Gunn S Hashimoto S Karakozov M Marx T Tan IK Thompson DR Vincent JL 《Critical care (London, England)》2004,8(4):213-218
A young person presents with a highly malignant brain tumour with hemiparesis and limited prognosis after resection. She then suffers an iatrogenic cardiac and respiratory arrest that results in profound anoxic encephalopathy. A difference in opinion between the treatment team and the parent is based on a question of futile therapy. Opinions from five intensivists from around the world explore the differences in ethical and legal issues. A Physician-ethicist comments on the various approaches. 相似文献
67.
Luccio-Camelo DC Une KN Ferreira RE Khoo SK Nickolov R Bronstein MD Vaisman M Teh BT Frohman LA Mendonça BB Gadelha MR 《European journal of endocrinology / European Federation of Endocrine Societies》2004,150(5):643-648
We report here the genetic findings of a new isolated familial somatotropinoma (IFS) kindred in which the mother (subject I:2) and one daughter (subject II:2) are affected; their ages at diagnosis were 25 and 14 years respectively. Additionally, patient I:2 developed virilization due to an androgen-secreting adrenocortical mass, presenting clinical and molecular features of sporadic adrenal carcinoma. To genotype this family and to narrow down the candidate interval of the putative IFS gene at 11q13, we performed haplotyping on the DNA from all five members of the family and allelotyping of one available somatotropinoma using polymorphic microsatellite markers from chromosome region 11q12.1-11q13.5. Results indicated that the disease haplotype, between markers D11S956 and D11S527, was transmitted from subject I:2 only to subject II:2. A meiotic recombination event was detected in the fraternal twin sister of II:2 (subject II:1), but her disease status is unknown. Since she is only 18 years old this genetic event cannot yet narrow down the area involved in the pathogenesis of IFS. Allelotyping of the somatotropinoma from II:2 revealed loss of the chromosome carrying the wild-type copy of the putative IFS gene inherited from her father. These results support the involvement of a tumor suppressor gene at 11q13.1-q13.3 in the pathogenesis of IFS. 相似文献
68.
69.
Benign paroxysmal positional vertigo: some recent advances 总被引:1,自引:0,他引:1
Bronstein AM 《Current opinion in neurology》2003,16(1):1-3
70.
Ziavra NV Yen Pik Sang FD Golding JF Bronstein AM Gresty MA 《Mayo Clinic proceedings. Mayo Clinic》2003,78(5):574-578
OBJECTIVE: To compare the effects of breathing supplemental oxygen vs air on alleviating motion sickness in healthy adults. SUBJECTS AND METHODS: Between April and July 2002, 20 healthy subjects were exposed to a provocative motion on 2 occasions (1-week interval) according to a randomized, counterbalanced, crossover design. During motion, subjects rated their nausea (1, no symptoms, to 4, moderate nausea) every 30 seconds. Once mild nausea occurred, subjects began breathing supplemental oxygen or air through a face mask. Motion ceased when moderate nausea occurred, but subjects continued breathing study gases for 5 minutes while recovering. Recovery was assessed for 20 minutes after motion. RESULTS: There were no significant differences in the rate of increase in symptom severity or the rate of recovery between the 2 conditions. CONCLUSION: Breathing supplemental oxygen had no advantage over breathing air in reducing motion sickness in healthy adults. 相似文献