全文获取类型
收费全文 | 591篇 |
免费 | 49篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 14篇 |
妇产科学 | 19篇 |
基础医学 | 86篇 |
口腔科学 | 20篇 |
临床医学 | 43篇 |
内科学 | 111篇 |
皮肤病学 | 9篇 |
神经病学 | 162篇 |
特种医学 | 24篇 |
外科学 | 31篇 |
综合类 | 10篇 |
预防医学 | 54篇 |
眼科学 | 15篇 |
药学 | 15篇 |
肿瘤学 | 17篇 |
出版年
2021年 | 5篇 |
2020年 | 3篇 |
2019年 | 9篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 9篇 |
2015年 | 13篇 |
2014年 | 13篇 |
2013年 | 21篇 |
2012年 | 34篇 |
2011年 | 32篇 |
2010年 | 19篇 |
2009年 | 12篇 |
2008年 | 29篇 |
2007年 | 23篇 |
2006年 | 27篇 |
2005年 | 24篇 |
2004年 | 18篇 |
2003年 | 21篇 |
2002年 | 23篇 |
2001年 | 19篇 |
2000年 | 22篇 |
1999年 | 22篇 |
1998年 | 14篇 |
1997年 | 8篇 |
1996年 | 12篇 |
1995年 | 9篇 |
1994年 | 6篇 |
1992年 | 14篇 |
1991年 | 8篇 |
1990年 | 16篇 |
1989年 | 16篇 |
1988年 | 10篇 |
1987年 | 14篇 |
1986年 | 17篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1981年 | 4篇 |
1979年 | 5篇 |
1976年 | 3篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1967年 | 9篇 |
1966年 | 9篇 |
1946年 | 2篇 |
排序方式: 共有643条查询结果,搜索用时 15 毫秒
71.
Suppression of visually evoked postural responses 总被引:5,自引:5,他引:0
Bronstein A. M. 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1986,63(3):655-658
Summary Normal subjects standing on an earth-fixed force platform inside a movable room displaced at velocities comparable to those accompanying spontaneous body sway, exhibit a visually evoked postural response (VEPR) some 600 ms after the start of the room movement. It consists of a displacement of the centre of force of the body in the direction of the stimulus (primary component), followed shortly by a corrective displacement in the opposite (secondary component). On second presentation of the stimulus VEPR is markedly reduced, but only if full proprioceptive information from the lower limbs is available to the subjects. A patient deprived of this information showed much enhanced VEPR which he was unable to suppress, in contrast to a patient with absent vestibular function who presented normal VEPR. The results show that in the presence of conflict between different sensory clues, vision is initially dominant in sway control, although adaptive processes can quickly rearrange this hierarchy. 相似文献
72.
Bronstein JM Vosel A Georsel SK Freeman C Payne LA 《Public health reports (Washington, D.C. : 1974)》2007,122(2):190-197
OBJECTIVES: This study examines whether Alabama's Medicaid family planning demonstration program reaches a different segment of the population than the health department-based Title X family planning program, whether service use rates differ across clients using care within and outside of the Title X provider system, and whether additional risk assessment and care coordination services provided by health department personnel increase the likelihood that family planning clients return for follow-up visits over time. METHODS: Administrative data from four years of operation of the program were used to examine characteristics of the clientele, differences in services used across provider types included in the program, and the impact of risk assessments and care coordination on return visit rates. RESULTS: The number of family planning service users increased dramatically over the four-year period, but were more similar demographically to Title X clients than to Medicaid maternity clients. Growth was greatest among clients of non-Title X providers. Newly covered services, including risk assessments and care coordination, were available mostly to Title X clients, and these services were associated with a greater likelihood that clients returned for care in subsequent years. CONCLUSION: Expanded provider networks can increase the number of low income women using family planning services while risk assessment and care coordination can improve the effectiveness of these services. However, enhanced services may not be equally available across provider systems. Additional outreach efforts are needed to reach women eligible for publicly supported family planning services who are not currently using these services. 相似文献
73.
Hyperbaric oxygen therapy for severe hydrogen sulfide poisoning 总被引:1,自引:0,他引:1
M J Smilkstein A C Bronstein H M Pickett B H Rumack 《The Journal of emergency medicine》1985,3(1):27-30
The optimum therapy for hydrogen sulfide poisoning is unclear. Adjuncts used in the treatment of cyanide poisoning have been advocated because of the shared mechanism of toxicity between hydrogen sulfide and cyanide. Following success in cyanide poisoning, hyperbaric oxygen therapy (HBO) has been suggested for use in treating hydrogen sulfide poisoning. A case of severe hydrogen sulfide poisoning was successfully treated with HBO after standard therapy was apparently ineffective. HBO as a therapeutic adjunct in hydrogen sulfide poisoning and the rationale for its use are discussed. 相似文献
74.
Paulo V.G.H. Amorim Isabella P.P. Grande Rafael L. Batista Leticia F.G. Silveira Ane Caroline T.B. Freire Marcello D. Bronstein Raquel S. Jallad Ericka B. Trarbach 《Annales d'endocrinologie》2019,80(2):96-100
Objectives
This study analyzed the KISS1 c.-145delA (rs5780218) promoter polymorphism in a cohort of patients with growth hormone secreting pituitary adenoma (somatotropinoma) and controls, to investigate its role in the incidence of acromegaly and to assess patient/tumor characteristics.Material and methods rs5780218 allelic and genotypic distributions were compared between 49 somatotropinoma patients and 167 healthy controls. rs5780218 was also assessed in relation to patient characteristics and tumor aggressiveness, as characterized by tumor invasion and resistance to conventional therapy. The relationship between KISS1 mRNA expression and the rs5780218 genotype was also assessed in available pituitary tumor samples.Results
The homozygous -/- variant genotype was associated with high rates of somatotropinoma (P < 0.01), but not with tumor invasiveness, patient characteristics or hormonal remission. KISS1 mRNA expression was much lower in somatotropinomas carrying the deleted allele than in homozygous wild type AA.Conclusions
In this pilot study, the rs5780218 promoter polymorphism was evaluated in pituitary adenoma, and showed a possible association with the incidence of somatotropinoma but not with tumor progression. 相似文献75.
76.
77.
78.
Alin Abreu Alejandro Pinzón Tovar Rafael Castellanos Alex Valenzuela Claudia Milena Gómez Giraldo Alejandro Castellanos Pinedo Doly Pantoja Guerrero Carlos Alfonso Builes Barrera Humberto Ignacio Franco Antônio Ribeiro-OliveiraJr. Lucio Vilar Raquel S. Jallad Felipe Gaia Duarte Mônica Gadelha Cesar Luiz Boguszewski Julio Abucham Luciana A. Naves Nina Rosa C. Musolino Maria Estela Justamante de Faria Ciliana Rossato Marcello D. Bronstein 《Pituitary》2016,19(4):448-457
Introduction
Acromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to the excess GH and IGF-1, thus early diagnosis and treatment is imperative. Unfortunately, acromegaly is often diagnosed late, when patients already have a wide range of comorbidities. The presence of comorbid conditions contributes significantly to patient morbidity/mortality and impaired quality of life.Methods
We conducted a retrospective literature review for information relating to the diagnosis of acromegaly, and its associated comorbidities using PubMed. The main aim of this review is to highlight the issues of comorbidities in acromegaly, and to reinforce the importance of early diagnosis and treatment.Findings and conclusions
Successful management of acromegaly goes beyond treating the disease itself, since many patients are diagnosed late in disease evolution, they present with a range of comorbid conditions, such as cardiovascular disease, diabetes, hypertension, and sleep apnea. It is important that patients are screened carefully at diagnosis (and thereafter), for common associated complications, and that biochemical control does not become the only treatment goal. Mortality and morbidities in acromegaly can be reduced successfully if patients are treated using a multimodal approach with comprehensive comorbidity management.79.
80.
Israel Bronstein Paul Montgomery Stephanie Dobrowolski 《Journal of traumatic stress》2012,25(5):551-557
This study concerned the mental health of Afghan unaccompanied asylum‐seeking children in the United Kingdom (UK). Afghans are the largest group of children seeking asylum in the UK, yet evidence concerning their mental health is limited. This study presents an estimate of probable posttraumatic stress disorder (PTSD) within this group and describes its associations with the cumulative effect of premigration traumatic events, immigration/asylum status, and social care living arrangements. Male adolescents (N = 222) aged 13–18 years completed validated self‐report screening measures for traumatic experiences and likely PTSD. One‐third (34.3%) scored above a selected cutoff, suggesting that they are likely to have PTSD. A higher incidence of premigration traumatic events was associated with greater PTSD symptomatology. Children living in semi‐independent care arrangements were more likely to report increased PTSD symptoms when compared to their peers in foster care. A substantial majority in this study did not score above the cutoff, raising the possibility of notable levels of resilience. Future research should consider approaching mental health issues from a resilience perspective to further the understanding of protective mechanisms for this at‐risk population. 相似文献