全文获取类型
收费全文 | 531篇 |
免费 | 21篇 |
国内免费 | 96篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 33篇 |
基础医学 | 43篇 |
口腔科学 | 19篇 |
临床医学 | 105篇 |
内科学 | 139篇 |
皮肤病学 | 7篇 |
神经病学 | 8篇 |
特种医学 | 109篇 |
外科学 | 16篇 |
综合类 | 35篇 |
预防医学 | 21篇 |
眼科学 | 5篇 |
药学 | 80篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 3篇 |
2022年 | 1篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 5篇 |
2018年 | 3篇 |
2017年 | 4篇 |
2016年 | 5篇 |
2015年 | 4篇 |
2014年 | 9篇 |
2013年 | 21篇 |
2012年 | 8篇 |
2011年 | 7篇 |
2010年 | 27篇 |
2009年 | 24篇 |
2008年 | 11篇 |
2007年 | 57篇 |
2006年 | 13篇 |
2005年 | 24篇 |
2004年 | 4篇 |
2003年 | 6篇 |
2002年 | 6篇 |
2001年 | 15篇 |
2000年 | 6篇 |
1999年 | 9篇 |
1998年 | 41篇 |
1997年 | 38篇 |
1996年 | 29篇 |
1995年 | 29篇 |
1994年 | 27篇 |
1993年 | 38篇 |
1992年 | 6篇 |
1991年 | 7篇 |
1990年 | 12篇 |
1989年 | 25篇 |
1988年 | 24篇 |
1987年 | 15篇 |
1986年 | 16篇 |
1985年 | 14篇 |
1984年 | 9篇 |
1983年 | 3篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 10篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 7篇 |
1976年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有648条查询结果,搜索用时 15 毫秒
101.
Audrey SL Low Mark Lunt Louise K Mercer James B Galloway Rebecca Davies Kath D Watson Deborah P Symmons William G Dixon Kimme L Hyrich 《Lancet》2013
BackgroundPeople with rheumatoid arthritis are at increased risk of cardiovascular morbidity and mortality, including stroke (cerebrovascular accident [CVA]). Anti-tumour necrosis factor (anti-TNF) therapy may influence the risk of CVA by reducing inflammation. The aim of the analysis was to study the association of anti-TNF therapy with risk of ischaemic CVA in rheumatoid arthritis.MethodsThe British Society for Rheumatology Biologics Registers-Rheumatoid Arthritis (BSRBR-RA) is an ongoing national prospective observational cohort study. Patients with rheumatoid arthritis recently started on anti-TNF therapy and a biologic-naive comparator group treated only with non-biologic disease modifying anti-rheumatic drugs (nbDMARDs) were recruited to the BSRBR-RA from 2001 to 2008. Patients were followed by physician and patient questionnaires and also linked to the national death register. Incident CVAs were identified from all three sources of follow-up. CVAs were validated against WHO criteria for CVA and further classified as ischaemic CVA using CT brain reports or if ischaemic CVA was reported as the underlying cause of death from death certificates according to International Classification of Diseases 10 (ICD-10) code I63. Patients with a previous CVA were excluded. Risk of ischaemic CVA was compared between the nbDMARD cohort and people ever exposed to anti-TNF using a Cox regression model. Missing baseline data were replaced by multiple imputation. Adjustment was made for confounders using propensity scores stratified by deciles.FindingsTo Oct 31, 2010, 130 verified incident ischaemic CVAs (21 in 3271 nbDMARD patients, 109 in 11 642 anti-TNF patients) had occurred during 11 973 and 61 226 person-years of observation, respectively (incidence rate 175 vs 178 per 100 000 person-years). After adjustment for confounders, there was no association between ever exposure to anti-TNF and ischaemic CVA risk (hazard ratio 0·88 [95% CI 0·46–1·71]).InterpretationExposure to anti-TNF therapy does not appear to be associated with risk of ischaemic CVA when compared with nbDMARD therapy. Further follow-up is needed to assess time-varying risk.FundingBritish Society for Rheumatology. 相似文献
102.
103.
104.
Background: This study evaluated the effectiveness of 400 mg ibuprofen arginate either as a pre‐emptive (PRE group) or postoperative (POST group) analgesic using a common dental pain model. Methods: A randomized double‐blind crossover clinical trial involving a series of consecutive patients admitted for bilateral third molar surgery. Results were analysed according to the self‐reported pain score and the pattern of rescue medication taken. Results: The mean pain score ranged from 0.73 to 1.60 for the PRE group and 0.47 to 1.41 for the POST group among 30 included subjects. The mean time point when first rescue medication taken was 7.3 hours and 8.3 hours postoperative, respectively. Nine patients (30 per cent) in the PRE group and 12 patients (40 per cent) in the POST group took no rescue medication. There was no statistically significant difference for all parameters between groups, while a majority (53 per cent) found the drug “good” to “excellent” in both groups. Conclusions: Ibuprofen arginate may be considered effective in reducing surgically induced moderate to severe pain when administered either pre‐operatively or postoperatively due to the reported relatively low pain score, less consumption of rescue medication, delayed onset of pain, good number of pain‐free patients and a high rating in the global assessment score. 相似文献
105.
Joseph F Goldberg Lori D McLeod Sheri E Fehnel Valerie SL Williams Lynne R Hamm Kim Gilchrist 《Bipolar disorders》2010,12(1):32-44
Goldberg JF, McLeod LD, Fehnel SE, Williams VSL, Hamm LR, Gilchrist K. Development and psychometric evaluation of the Bipolar Functional Status Questionnaire (BFSQ). Bipolar Disord 2010: 12: 32–44. © 2010 The Authors.Journal compilation © 2010 John Wiley & Sons A/S. Objectives: Persistently impaired psychosocial functioning has been recognized in many individuals with bipolar disorder. However, existing measures of functional disability have been adapted for use in bipolar disorder based mainly on those developed for use in other conditions. The present study involved the development and validation of a new patient self‐report measure specific to bipolar disorder, the Bipolar Functional Status Questionnaire (BFSQ). Methods: Relevant constructs were identified, evaluated, and refined through an expert advisory panel in conjunction with patient interviews. Questionnaire items were vetted through iterative patient interviews. Psychometric properties were determined based on patient responses from implementation of the proposed 33‐item questionnaire in an 11‐site study of 596 patients with bipolar disorder across varied phases of illness. Results: Eight constructs were identified as fundamental to functional status in bipolar disorder: cognitive function, sleep, role functioning, emotional functioning, energy/vitality, social functioning, personal management, and sexual functioning. Psychometric validation supported item reduction to a 24‐item unidimensional scale, with high internal consistency (coefficient α’s = 0.93–0.95), high test‐retest reliability (intraclass correlation coefficient = 0.86, 95% confidence interval = 0.82–0.89), strong convergent validity with other functional disability measures (r’s > 0.70), and highly significant discriminant validity across illness phases, with large effect sizes (Cohen’s d > 0.70). Conclusions: The BFSQ is a psychometrically sound self‐report measure that can be used to effectively quantify functional status across different clinical states in patients with bipolar disorder. 相似文献
106.
107.
Jeroen SL de Munter Irene GM van Valkengoed Charles Agyemang Anton E Kunst Karien Stronks 《The international journal of behavioral nutrition and physical activity》2010,7(1):1-8
Purpose
The level of recommended physical activity (PA) is met less frequently by people from some ethnic minorities than others. We explored whether these differences in recommended PA between ethnic minority groups and the general population varied by domain and type of culturally-specific activity.Methods
Participants were sampled from the population based SUNSET study and were from ethnic Dutch (n = 567), Hindustani-Surinamese (n = 370) and African-Surinamese (n = 689) descent. The validated SQUASH-questionnaire measured PA for the following domains: commuting, occupation, household, leisure time. Culturally-specific activities were added as extra question within the leisure time domain. The effect of each domain on ethnic differences in recommended PA prevalence was examined by odds-ratio (OR) analysis through recalculating recommended PA, while, in turn, excluding the contribution of each domain.Results
In the ethnic Dutch population, more vigorous PA in commuting and leisure time was reported compared to the Surinamese groups. The Hindustani-Surinamese and African-Surinamese reported more walking as commuting activity, while the Dutch group reported cycling more frequently. Ethnic differences in recommended PA became smaller in both Surinamese groups compared with the Dutch after removing commuting activity, for example, in Hindustani-Surinamese men (OR = 0.92, 95%CI: 0.62-1.37 vs. OR = 1.33, 0.89-2.00) and women (OR = 1.61, 1.12-2.32 vs. OR = 2.03, 1.41-2.92). Removing occupational activity resulted in larger ethnic differences in both groups compared with the Dutch. Smaller effects were found for yoga and dancing, leisure time and household activities.Conclusion
This study shows that differences in PA between ethnic minority groups and the general population vary according to the activity domain. The results indicate that including all relevant domains and activities is essential for assessment of ethnic differences in recommended PA. 相似文献108.
Linda S Deal Dana Britt DiBenedetti Valerie SL Williams Sheri E Fehnel 《Health and quality of life outcomes》2010,8(1):64
Background
The objective of this study was to develop and validate a daily electronic Endometriosis Pain and Bleeding Diary (EPBD) for assessing treatment-related changes in endometriosis symptoms from the patient's perspective in a clinical trial setting. 相似文献109.
110.
The present study has been carried out to study the hostility pattern of surgeons and compare it with other specialities. 100 teachers working in different specialities in Post Graduate Institute of Medical Sciences (PGIMS) Rohtak (Surgery and allied specialties 21, Medical and allied specialities 14, Non-clinical specialities 30) were given Hostility and Direction of Hostility Questionnaire (HDHQ) along with questions regarding their choice of career and Job satisfaction. Hostility pattern did not differ statistically among these groups. Surgeons showed strong aptitude for the field and were contended with their choice of speciality but their Job satisfaction was low. Possible explanations and implications of the study are discussed.Key Words: Hostility, Job satisfaction, Surgeons 相似文献