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Recent advances in regeneration and pain research have revealed gaps in the understanding of normal C-fiber anatomy. In the rat PNS, C-fiber axons assemble into Remak bundles, but beyond this, features of C-fiber organization are not defined. Systematic sampling and quantitation reveals that Remak bundles exiting from the L5 dorsal root ganglion (DRG) contain large numbers of axons, for example, 56% of unmyelinated axons were in bundles of >20 axons. This is different from distal nerve segments such as the hindpaw plantar nerve where the median number of axons per bundle is 3. The cross-sectional area of unmyelinated axons in dorsal root was homogeneous near the DRG but variability in axonal area increased near the spinal cord (p = 0.00001) and the mean axonal area was unchanged. Unmyelinated axons in peripheral nerve were almost always isolated from one another by Schwann cell processes; however, in dorsal root 7% to 9% of unmyelinated axons were immediately adjacent within pockets containing 2 or more axons. Remak bundles in the distal peripheral nerve clustered with other Remak bundles. We observe that multiple unmyelinated axons are juxtaposed within the C-fiber/Remak bundle and that the close association of afferent axons may have important functional implications. 相似文献
73.
A simultaneous liquid chromatography/mass spectrometric assay of glutathione,cysteine, homocysteine and their disulfides in biological samples 总被引:2,自引:0,他引:2
Guan X Hoffman B Dwivedi C Matthees DP 《Journal of pharmaceutical and biomedical analysis》2003,31(2):251-261
A liquid chromatography/mass spectrometric (LC/MS) method was developed for simultaneous detection and quantitation of glutathione (GSH), glutathione disulfide (GSSG), cysteine (CysSH), homocysteine (HCysSH) and homocystine in biological samples (rat brain, lung, liver, heart, kidneys, erythrocytes and plasma). Thiols were derivatized with a large excess of Ellman's reagent, a thiol-specific reagent, to ensure an instantaneous and complete derivatization. The derivatization blocked the oxidation of the thiols to disulfides, preventing errors caused by thiol oxidation. The samples were then analyzed by LC/MS. The method provides a highly selective and sensitive assay for these endogenous thiols and their corresponding disulfides. The detection limits for GSH, GSSG, CysSH, HCysSH and homocystine were 3.3, 3.3, 16.5, 29.6 and 14.9 pmol, respectively. An attempt for cystine analysis was unsuccessful due to earlier elution of the compound and strong interferences caused by other endogenous compounds. This method will be a useful tool in the investigation of the roles of these important thiol-containing compounds and their corresponding disulfides in physiological and pathological processes. 相似文献
74.
对36例先天性耳前瘘管患者采用口医中药分期治疗,酿脓期内服解毒排脓汤,外敷清热消肿膏;脓溃管存期用拔瘰丹腐蚀拔管;收口期外用生肌散。结果:36例全部治愈,观察一年无复发。拔瘰丹拔管用法讲究,可免手术之苦。 相似文献
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Barbara L. Conner-Spady PhD Geoffrey H. Johnston MD MBA FRCSC † Claudia Sanmartin PhD ‡ John J. McGurran MSc § Tom W. Noseworthy MD MSc MPH ¶ the Saskatchewan Surgical Care Network/Western Canada Waiting List Project Research Evaluation Working Group Committee 《Health expectations》2007,10(2):108-116
OBJECTIVES: To obtain patients' perspectives on acceptable waiting times for hip or knee replacement surgery. METHODS: A questionnaire with both open- and close-ended items was mailed to 432 consecutive patients who had hip or knee replacement surgery 3-12 months previously in Saskatchewan, Canada. A content analysis was used to analyse the text data from the open-ended questions. RESULTS: The sample of 303 (response rate 70%) was 59% female with a mean age of 70 years (SD 11). The median waiting time from the decision date to surgery was 17 weeks. Individuals who rated their waiting time very acceptable (48%) had a median waiting time of 13 weeks compared with a median waiting time of 22 weeks for those who rated it unacceptable (23%). The two most common determinants of acceptability were patient expectations and pain and its impact on patient quality of life. The median maximum acceptable waiting time was 13 weeks and median ideal waiting time, 8.6 weeks. Seventy-nine per cent felt that those in greater need (higher severity) should go before them on the waiting list. Patient ratings of maximum acceptable waiting time were based on: pain and loss of mobility, time needed to prepare for surgery, and severity at the time of seeing the surgeon. In consideration of changing their surgeon to one with a shorter waiting list, 68% would not. CONCLUSIONS: Patient views on waiting times are not only related to quality of life issues, but also to prior expectations and notions of fairness and priority. Understanding patient views on waiting for surgery has implications for better management of waiting times and experiences for joint replacement. 相似文献
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补肾,健脾,活血三类中药复方对脑室内注射白细胞介素—1 … 总被引:6,自引:0,他引:6
目的:探索补肾,健脾,活血三类中药复方对免疫因子引起的下丘脑单胺类神经递质的不同影响。方法:用侧脑室注射白细胞介素-1β(IL-1β),观测大鼠下丘脑匀浆液中单胺类神经递质的变化,建立一个下丘脑单胺类神经细胞功能对免疫因子的反应状态,以此观察三类中经对这一反应状态的不同影响。结果:侧脑室内注射IL-1β能使下丘脑匀浆液中去甲肾上腺素(NE)含量明显降低;补肾的右归饮能使因侧脑室注射IL-1β引起下 相似文献
80.
目的 观察清营I号对兔颈静脉血栓(VT)形态学演变的影响。方法 通过对兔颈VT模型进行分期论治及分组对比观察,就血栓机化程度、内皮细胞变化、炎性浸润程度进行同期观测。结果 VT后7d血栓与静脉壁粘连,内皮细胞脱落,炎性浸润严重。至15d中央区血栓崩解,形成腔隙,表面内皮细胞部分覆盖,炎性浸润明显;治疗后15d腔内血栓消失,内皮细胞修复,形态完整。治疗效果优于丹参组。结论 清营I号具有促进血栓机化,修复血管内皮细胞,改善血管炎变作用,且随着内皮细胞的修复,其功能得以改善。 相似文献