全文获取类型
收费全文 | 4932篇 |
免费 | 285篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 218篇 |
妇产科学 | 82篇 |
基础医学 | 552篇 |
口腔科学 | 243篇 |
临床医学 | 376篇 |
内科学 | 1195篇 |
皮肤病学 | 100篇 |
神经病学 | 369篇 |
特种医学 | 245篇 |
外科学 | 772篇 |
综合类 | 46篇 |
一般理论 | 2篇 |
预防医学 | 449篇 |
眼科学 | 53篇 |
药学 | 277篇 |
2篇 | |
中国医学 | 15篇 |
肿瘤学 | 173篇 |
出版年
2023年 | 28篇 |
2022年 | 31篇 |
2021年 | 59篇 |
2020年 | 39篇 |
2019年 | 79篇 |
2018年 | 126篇 |
2017年 | 84篇 |
2016年 | 66篇 |
2015年 | 133篇 |
2014年 | 114篇 |
2013年 | 196篇 |
2012年 | 292篇 |
2011年 | 299篇 |
2010年 | 175篇 |
2009年 | 138篇 |
2008年 | 274篇 |
2007年 | 258篇 |
2006年 | 211篇 |
2005年 | 190篇 |
2004年 | 174篇 |
2003年 | 145篇 |
2002年 | 180篇 |
2001年 | 145篇 |
2000年 | 148篇 |
1999年 | 136篇 |
1998年 | 64篇 |
1997年 | 65篇 |
1996年 | 63篇 |
1995年 | 49篇 |
1994年 | 50篇 |
1993年 | 56篇 |
1992年 | 85篇 |
1991年 | 82篇 |
1990年 | 79篇 |
1989年 | 105篇 |
1988年 | 99篇 |
1987年 | 79篇 |
1986年 | 58篇 |
1985年 | 89篇 |
1984年 | 39篇 |
1983年 | 38篇 |
1982年 | 23篇 |
1980年 | 30篇 |
1979年 | 45篇 |
1978年 | 22篇 |
1977年 | 31篇 |
1976年 | 26篇 |
1975年 | 26篇 |
1974年 | 25篇 |
1969年 | 24篇 |
排序方式: 共有5246条查询结果,搜索用时 15 毫秒
91.
92.
Malte Lenders J?rg Stypmann Thomas Duning Boris Schmitz Stefan-Martin Brand Eva Brand 《Journal of the American Society of Nephrology : JASN》2016,27(1):256-264
Fabry disease (FD) is a progressive multisystemic disorder, treatable with recombinant enzyme replacement therapy (agalsidase). However, recent studies suggest an endogenous inhibition of agalsidase in patients with FD, as reported for other lysosomal storage diseases. To assess the clinical consequences of serum-mediated agalsidase inhibition in affected patients, we determined the agalsidase inhibition status of 168 patients (68 male) with FD and compared outcomes of inhibition-positive patients with those of inhibition-negative patients. The assessment included clinical events during time on agalsidase, determination of renal and cardiac function, and evaluation of FD-related symptoms. The frequency of serum-mediated agalsidase inhibition was 40% in agalsidase-treated males. Inhibition did not depend on the compound initially used (agalsidase-α or -β). Agalsidase inhibition was associated with higher lyso-globotriaosylceramide levels and worse disease severity scores in patients. Compared with agalsidase inhibition-negative men, agalsidase inhibition-positive men showed greater left ventricular mass (P=0.02) and substantially lower renal function (difference in eGFR of about –30 ml/min per 1.73 m2; P=0.04), which was confirmed by a longitudinal 5-year retrospective analysis. Additionally, affected patients presented more often with FD-typical symptoms, such as diarrhea, fatigue, and neuropathic pain, among others. Therefore, patients with poor clinical outcome on agalsidase should be tested for agalsidase inhibition. Future studies are warranted to determine if affected patients with FD benefit from acute reduction of anti-agalsidase antibodies or long-term immune modulation therapies to suppress agalsidase inhibition and to identify mechanisms that minimize antibody generation against agalsidase. 相似文献
93.
Clinical validation of the nursing diagnosis of ineffective protection in haemodialysis patients
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jéssica Dantas de Sá Tinôco RN MsN Maria das Graças Mariano Nunes de Paiva RN MsN Kadyjina Daiane Batista Lucio RN Maria Isabel da Conceição Dias Fernandes RN MsN Marcos Venicios de Oliveira Lopes RN MsN PhD Ana Luisa Brandão de Carvalho Lira RN MsN PhD 《Journal of clinical nursing》2018,27(1-2):e195-e202
94.
95.
96.
97.
This paper reports on an experimental study that examines the relative effect of price and personal referral cues on the consumers' perception of dental services. The results of the study show that price and personal referral do effect the perceived competence of the dentist as well as consumer purchase probability. 相似文献
98.
Kristine?S?rensen Stephan?Van den Broucke James?Fullam Gerardine?Doyle Jürgen?Pelikan Zofia?Slonska Helmut?Brand Consortium Health Literacy Project European 《BMC public health》2012,12(1):80
Background
Health literacy concerns the knowledge and competences of persons to meet the complex demands of health in modern society. Although its importance is increasingly recognised, there is no consensus about the definition of health literacy or about its conceptual dimensions, which limits the possibilities for measurement and comparison. The aim of the study is to review definitions and models on health literacy to develop an integrated definition and conceptual model capturing the most comprehensive evidence-based dimensions of health literacy. 相似文献99.
100.
Coronary flow regulation in mouse heart during hypercapnic acidosis: role of NO and its compensation during eNOS impairment 总被引:2,自引:0,他引:2
AIMS: This study addressed the hypotheses that the hypercapnic flow response in wild-type (WT) mouse heart is mainly mediated by nitric oxide (NO) and, thus, severely blunted in endothelial nitric oxide synthase knockout (eNOS-KO) mice and in WT mice after continuous pharmacological block (2 weeks) of NOS enzymes (WT-LN). METHODS AND RESULTS: Step changes of arterial pCO(2) were performed in isolated perfused hearts (n = 105). Contributions of NOS (L-NAME, TRIM), cyclooxygenase (indomethacin), epoxyeicosanotrienes (miconazole), adenosine A2A-receptors (SCH 58261), KV-channels (4-AP), KCa-channels (TEA), and K ATP-channels (glibenclamide) were studied in WT and eNOS-KO mouse hearts. Change of arterial pCO(2) increased coronary flow by 31.3 +/- 4% in WT, a response that was significantly decreased to 9.2 +/- 6% after L-NAME. Additional glibenclamide infusion (n = 5) completely abolished the steady-state flow increase during hypercapnic acidosis (-4.2 +/- 2.3%, P = 0.004 vs. control). Hearts from eNOS-KO mice as well as WT-LN showed a fully preserved flow response insensitive towards NOS-blockade. Whereas indomethacin, miconazole, TEA, and SCH 58261 were ineffective to reduce the flow response, glibenclamide blunted it in eNOS-KO hearts. CONCLUSION: NO-production and K ATP-channel activation together may fully account for the steady-state hypercapnic flow response in mouse heart. However, chronic deletion of eNOS does not result in a reduced hypercapnic flow response. Enhanced activation of K ATP-channels and potentially Kv-channels contributes to the compensatory mechanisms involved in the hypercapnic flow response when eNOS activity is absent. 相似文献