全文获取类型
收费全文 | 2804篇 |
免费 | 150篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 114篇 |
妇产科学 | 97篇 |
基础医学 | 319篇 |
口腔科学 | 271篇 |
临床医学 | 223篇 |
内科学 | 549篇 |
皮肤病学 | 63篇 |
神经病学 | 171篇 |
特种医学 | 182篇 |
外科学 | 322篇 |
综合类 | 43篇 |
预防医学 | 266篇 |
眼科学 | 11篇 |
药学 | 194篇 |
中国医学 | 24篇 |
肿瘤学 | 107篇 |
出版年
2023年 | 18篇 |
2022年 | 35篇 |
2021年 | 86篇 |
2020年 | 55篇 |
2019年 | 83篇 |
2018年 | 94篇 |
2017年 | 62篇 |
2016年 | 64篇 |
2015年 | 99篇 |
2014年 | 113篇 |
2013年 | 141篇 |
2012年 | 175篇 |
2011年 | 187篇 |
2010年 | 131篇 |
2009年 | 111篇 |
2008年 | 132篇 |
2007年 | 142篇 |
2006年 | 124篇 |
2005年 | 100篇 |
2004年 | 73篇 |
2003年 | 75篇 |
2002年 | 85篇 |
2001年 | 46篇 |
2000年 | 53篇 |
1999年 | 49篇 |
1998年 | 58篇 |
1997年 | 51篇 |
1996年 | 51篇 |
1995年 | 25篇 |
1994年 | 41篇 |
1993年 | 32篇 |
1992年 | 40篇 |
1991年 | 26篇 |
1990年 | 29篇 |
1989年 | 34篇 |
1988年 | 25篇 |
1987年 | 38篇 |
1986年 | 25篇 |
1985年 | 15篇 |
1984年 | 16篇 |
1983年 | 14篇 |
1982年 | 15篇 |
1981年 | 12篇 |
1980年 | 14篇 |
1977年 | 16篇 |
1976年 | 10篇 |
1975年 | 10篇 |
1970年 | 8篇 |
1967年 | 4篇 |
1964年 | 5篇 |
排序方式: 共有2979条查询结果,搜索用时 156 毫秒
151.
AL Naik A Savlania A Gupta P Rastogi A Singh 《Annals of the Royal College of Surgeons of England》2021,103(3):e94
Behçet’s disease is a rare disease characterised by recurrent oral ulcers, with systemic manifestations including genital ulcers, ocular disease, skin lesions, gastrointestinal disease, neurologic disease, vascular disease and arthritis. Most clinical manifestations of Behçet’s disease are believed to be due to vasculitis. The heterogeneous clinical spectrum is influenced by sex, ethnicity and country of residence. Vascular manifestation in the form of isolated large brachial artery aneurysm is rare in children. Treatment involves aneurysmorrhaphy to avoid rupture or ischaemic sequelae in addition to lifelong medical management to control vasculitis. 相似文献
152.
153.
Indiara Brusco Simone Li Puma Kelly Braga Chiepe Evelyne da Silva Brum Caren Tatiane de David Antoniazzi Amanda Spring de Almeida Camila Camponogara Cássia Regina Silva Francesco De Logu Vanessa Moraes de Andrade Juliano Ferreira Pierangelo Geppetti Romina Nassini Sara Marchesan Oliveira Gabriela Trevisan 《International journal of cancer. Journal international du cancer》2020,146(10):2797-2809
Antineoplastic therapy has been associated with pain syndrome development characterized by acute and chronic pain. The chemotherapeutic agent dacarbazine, used mainly to treat metastatic melanoma, is reported to cause painful symptoms, compromising patient quality of life. Evidence has proposed that transient receptor potential ankyrin 1 (TRPA1) plays a critical role in chemotherapy-induced pain syndrome. Here, we investigated whether dacarbazine causes painful hypersensitivity in naive or melanoma-bearing mice and the involvement of TRPA1 in these models. Mouse dorsal root ganglion (DRG) neurons and human TRPA1-transfected HEK293 (hTRPA1-HEK293) cells were used to evaluate the TRPA1-mediated calcium response evoked by dacarbazine. Mechanical and cold allodynia were evaluated after acute or repeated dacarbazine administration in naive mice or after inoculation of B16-F10 melanoma cells in C57BL/6 mice. TRPA1 involvement was investigated by using pharmacological and genetic tools (selective antagonist or antisense oligonucleotide treatment and Trpa1 knockout mice). Dacarbazine directly activated TRPA1 in hTRPA1-HEK293 cells and mouse DRG neurons and appears to sensitize TRPA1 indirectly by generating oxidative stress products. Moreover, dacarbazine caused mechanical and cold allodynia in naive but not Trpa1 knockout mice. Also, dacarbazine-induced nociception was reduced by the pharmacological TRPA1 blockade (antagonism), antioxidants, and by ablation of TRPA1 expression. TRPA1 pharmacological blockade also reduced dacarbazine-induced nociception in a tumor-associated pain model. Thus, dacarbazine causes nociception by TRPA1 activation, indicating that this receptor may represent a pharmacological target for treating chemotherapy-induced pain syndrome in cancer patients submitted to antineoplastic treatment with dacarbazine. 相似文献
154.
155.
156.
Summary The use of three‐dimensional (3D) models of the dentition obtained from cone beam computed tomography (CBCT) is becoming increasingly more popular in dentistry. A recent trend is to replace the traditional dental casts with digital CBCT models for diagnosis, treatment planning and simulation. The accuracy of these models was previously assessed through comparing linear physical and radiographical measurements. However, this assessment technique is both observer and landmark dependent. The accuracy of 3D CBCT teeth reconstructions is yet to be reliably measured. To assess the accuracy of 3D CBCT reconstructions of the teeth using a semi‐automated and observer‐independent method and to assess the influence of field of view (FoV) selection on reconstruction accuracy. Fully dentate upper and lower dry human jaws, placed in a plastic box and immersed in water, were scanned using CBCT with small, medium and large FoV. The teeth were then scanned separately using MicroCT. Cone beam computed tomography and MicroCT 3D teeth models were compared, and mean surface difference was calculated per tooth for each FoV. Mean and (maximum) differences between MicroCT and CBCT were 120 ± 40 (max. 679) μm, 157 ± 39 (max. 824) μ and 207 ± 80 (max. 862) μm for the small, medium and large FoV, respectively. Cone beam computed tomography models were larger than MicroCT because of larger voxel size. Our results indicate that CBCT may provide accurate 3D reconstructions of the teeth that can be useful for some clinical applications. 相似文献
157.
Andrea F.V. Santos Carina B. Tanaka Raul G. Lima Camila O.M. Espósito Rafael Y. Ballester Roberto R. Braga Josete B.C. Meira 《Journal of endodontics》2009,35(1):117-120
Upper premolars restored with endodontic posts present a high incidence of vertical root fracture (VRF). Two hypotheses were tested: (1) the smaller mesiodistal diameter favors stress concentration in the root and (2) the lack of an effective bonding between root and post increases the risk of VRF. Using finite element analysis, maximum principal stress was analyzed in 3-dimensional intact upper second premolar models. From the intact models, new models were built including endodontic posts of different elastic modulus (E = 37 or E = 200 GPa) with circular or oval cross-section, either bonded or nonbonded to circular or oval cross-section root canals. The first hypothesis was partially confirmed because the conditions involving nonbonded, low-modulus posts showed lower tensile stress for oval canals compared to circular canals. Tensile stress peaks for the nonbonded models were approximately three times higher than for the bonded or intact models, therefore confirming the second hypothesis. 相似文献
158.
159.