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101.
Growth in Crohn's disease 总被引:2,自引:0,他引:2
MO Savage RM Beattie C Camacho-Hübner JA Walker-Smith IR Sanderson 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(S428):89-92
Savage MO, Beattie RM, Camacho-Hubner C, Walker-Smith JA, Sanderson IR. Growth in Crohn's disease. Acta Paediatr 1999; Suppl 428:89-92. Stockholm. ISSN 0803-5326
Abnormal linear growth is frequent in children and adolescents with Crohn's disease. The typical pattern is of growth retardation associated with delayed skeletal maturation. Puberty is also frequently delayed. Over 50% of patients may have a subnormal height velocity, and approximately 25% will have short stature. The endocrine status is characterized by normal growth hormone secretion and a slightly subnormal serum level of insulin-like growth factor I, which is related to nutritional status. Principal therapeutic options are intestinal resection for localized disease, and enteral nutrition - using a polymeric diet - for more widespread disease, particularly involving the small intestine. Growth responses to both modalities are often excellent and produce considerable psychological benefit. Optimum therapy is achieved by close collaboration between gastroenterologists and endocrinologists, and by the use of auxologicalmethods to document pre- and post-therapeutic management. □ Crohn 's disease, enteral nutrition, growth, intestinal resection, puberty 相似文献
Abnormal linear growth is frequent in children and adolescents with Crohn's disease. The typical pattern is of growth retardation associated with delayed skeletal maturation. Puberty is also frequently delayed. Over 50% of patients may have a subnormal height velocity, and approximately 25% will have short stature. The endocrine status is characterized by normal growth hormone secretion and a slightly subnormal serum level of insulin-like growth factor I, which is related to nutritional status. Principal therapeutic options are intestinal resection for localized disease, and enteral nutrition - using a polymeric diet - for more widespread disease, particularly involving the small intestine. Growth responses to both modalities are often excellent and produce considerable psychological benefit. Optimum therapy is achieved by close collaboration between gastroenterologists and endocrinologists, and by the use of auxologicalmethods to document pre- and post-therapeutic management. □ Crohn 's disease, enteral nutrition, growth, intestinal resection, puberty 相似文献
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Abstract: Two consumer representatives were participants in the development of their state government’s Policy for Planned Birth At Home in South Australia. It was released in November 2007 to guide staff in public hospital and community midwifery programs, and the first hospital‐based home birth service is commencing in February 2009. Consumer experiences of policy development and perceived benefits of consumer involvement for policy and transparency processes are described. Inclusion of consumers widely and actively during development and reform of maternity care is essential if real consumer participation is to occur and contribute to care that is truly woman‐centered. (BIRTH 36:1 March 2009) 相似文献
103.
REUmeh IREzegwuit 《国际眼科杂志》2005,5(2):229-231
目的:比较盘尾丝虫病高流行地区和低流行地区的眼压分布状况。方法:用多级分组随机采样方法从2个盘尾丝虫病农村高流行地区选择调查对象,检查受试眼球前后段,用Schiotz眼压计检查眼压(IOP)。对照组选自1个盘尾丝虫病低流行地区,并对其做相同的眼部检查。结果:共有360名来自盘尾丝虫病高流行地区的受试接受检查,平均眼压为右眼18.1mmHg、左眼18.0mmHg。一个盘尾丝虫病低流行地区眼科门诊的100名非青光眼患组成对照组,平均眼压为右眼21.8mmHg,左眼21.5mmHg。盘尾丝虫病高流行地区受试组的平均眼压比低流行地区对照组低3.5mmHg。结论:盘尾丝虫病有可能诱发睫状体轻微炎症反应,从而引起早期眼压降低。 相似文献
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Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis 总被引:3,自引:0,他引:3
Makrygiannakis D af Klint E Catrina SB Botusan IR Klareskog E Klareskog L Ulfgren AK Catrina AI 《Arthritis and rheumatism》2006,54(5):1463-1472
OBJECTIVE: Intraarticular corticosteroids are frequently used as successful adjuvant therapy for inflammatory arthritides, but little is known about their effects on molecules that regulate bone biology. We undertook this study to investigate the effect of intraarticular corticosteroids on the synovial expression of RANKL and osteoprotegerin (OPG). METHODS: We evaluated RANKL, OPG, and surface marker expression by immunohistochemical methods in synovial knee biopsy samples obtained from 13 patients with inflammatory arthritis before and 2 weeks following intraarticular injection of triamcinolone hexacetonide. We further investigated the effect of dexamethasone (DEX) on RANKL expression by lymphocytes from rheumatoid arthritis synovial fluids (RA SF), using flow cytometric analysis. Finally, we evaluated the in vitro effect of DEX on RANKL and OPG expression in osteoblast-like cells, by Western blotting. RESULTS: Intraarticular corticosteroids induced a decrease in the number of synovial T cells without influencing the number of macrophages, evaluated as both CD68+ and CD163+ cells. This change was paralleled by a decrease of synovial RANKL expression with a concomitant reduction of the RANKL:OPG ratio. DEX down-regulated RANKL expression on lymphocytes derived from RA SF. Moreover, in vitro pretreatment of osteoblast-like cells with tumor necrosis factor favored an antiresorptive effect of DEX treatment through a similar down-regulation of RANKL expression. CONCLUSION: The decrease in inflammation attributed to intraarticular corticosteroids is accompanied by down-modulation of bone destruction markers. These findings offer a rationale for the beneficial effect of corticosteroids on joint erosion in arthritis. 相似文献
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