全文获取类型
收费全文 | 905篇 |
免费 | 68篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 30篇 |
妇产科学 | 22篇 |
基础医学 | 160篇 |
口腔科学 | 9篇 |
临床医学 | 77篇 |
内科学 | 251篇 |
皮肤病学 | 6篇 |
神经病学 | 91篇 |
特种医学 | 11篇 |
外科学 | 124篇 |
综合类 | 6篇 |
预防医学 | 62篇 |
眼科学 | 40篇 |
药学 | 42篇 |
肿瘤学 | 38篇 |
出版年
2023年 | 8篇 |
2022年 | 18篇 |
2021年 | 54篇 |
2020年 | 19篇 |
2019年 | 47篇 |
2018年 | 50篇 |
2017年 | 24篇 |
2016年 | 28篇 |
2015年 | 31篇 |
2014年 | 45篇 |
2013年 | 49篇 |
2012年 | 72篇 |
2011年 | 63篇 |
2010年 | 28篇 |
2009年 | 19篇 |
2008年 | 49篇 |
2007年 | 45篇 |
2006年 | 44篇 |
2005年 | 30篇 |
2004年 | 37篇 |
2003年 | 28篇 |
2002年 | 26篇 |
2001年 | 15篇 |
2000年 | 13篇 |
1999年 | 13篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 8篇 |
1995年 | 6篇 |
1993年 | 2篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 12篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1985年 | 9篇 |
1984年 | 4篇 |
1982年 | 3篇 |
1980年 | 2篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1969年 | 2篇 |
1967年 | 4篇 |
1966年 | 4篇 |
排序方式: 共有977条查询结果,搜索用时 78 毫秒
51.
Esther García Rojo Borja García Gómez Rocio Santos-Pérez de la Blanca Celeste Manfredi Manuel Alonso Isa José Medina Polo Alfredo Rodríguez Antolín Javier Romero Otero 《Asian journal of andrology》2021,(3):325-329
Neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)have been associated with multiple entities and several types of cancers.They can be ass... 相似文献
52.
Silvia Cmara M Concepcin Fournier Patricia Cordero Javier Melero Fernando Robles Borja Esteso M Teresa Vara Serafn Rodrguez lvaro Lassaletta Marcelo Budke 《Cerebellum (London, England)》2020,19(1):78-88
Cerebellar mutism syndrome (CMS) is a common surgical sequela in children following posterior fossa tumor (PFT) resection. Here, we analyze the neuropsychological features associated with PFT in children, focusing particularly on the differential profiles associated with the presence or absence of CMS after surgery. We further examine the effect of post-resection treatments, tumor type, and presence/absence of hydrocephalus on surgical outcome. Thirty-six patients diagnosed with PFT (19 with and 17 without CMS) and 34 age- and gender-matched healthy controls (HCs) were recruited. A comprehensive neuropsychological evaluation was conducted in all patients postoperatively and in HCs, including an assessment of general cognitive ability, motor skills, perception, language, memory, attention, executive functions, and academic competence. CMS was found to be a clinical marker of lower neuropsychological profile scores across all cognitive domains except auditory-verbal processing and visual memory tasks. PFT patients not presenting CMS exhibited milder impairment in intellectual functioning, motor tasks, reasoning, language, verbal learning and recall, attention, cognitive executive functions, and academic competence. High-grade tumors were associated with slower processing speed and verbal delayed recall as well as alterations in selective and sustained attention. Hydrocephalus was detrimental to motor functioning and nonverbal reasoning. Patients who had undergone surgery, chemotherapy, and radiotherapy presented impaired processing speed, verbal learning, and reading. In addition to the deleterious effects of PFT, post-resection PFT treatments have a negative cognitive impact. These undesired consequences and the associated tumor-related damage can be assessed using standardized, long-term neuropsychological evaluation when planning rehabilitation. 相似文献
53.
Toniolo Sofia Cercignani Mara Mora-Peris Borja Underwood Jonathan Alagaratnam Jasmini Bozzali Marco Boffito Marta Nelson Mark Winston Alan Vera Jaime H. 《Journal of neurovirology》2020,26(5):754-763
Journal of NeuroVirology - We assessed changes in functional connectivity by fMRI (functional magnetic resonance imaging) and cognitive measures in otherwise neurologically asymptomatic people with... 相似文献
54.
Claudio Carnevale Luis Ferrn‐De la Cierva Guillermo Til‐Prez Jos Antonio Pea‐Zarza Borja Osona‐Rodriguez Joaquina Martinez‐Lozano Pedro Sarría‐Echegaray Diego Arancibia‐Tagle Manuel Toms‐Barbern 《The Laryngoscope》2019,129(4):1001-1004
Recurrent respiratory papillomatosis can be a devastating condition for a child, with severe consequences. Currently, there is no proven successful medical treatment. We describe the use of systemic bevacizumab to treat two children affected by aggressive recurrent respiratory papillomatosis. Respiratory symptoms and quality of life improved dramatically in both patients, without observing any toxicity. The only complication was mild proteinuria. Systemic bevacizumab is a promising adjuvant treatment in aggressive recurrent respiratory papillomatosis in children. It is effective and well tolerated. Further studies are needed to establish the optimal dosing frequency and duration of therapy. Laryngoscope, 129:1001–1004, 2019 相似文献
55.
Heil M Ziegelhoeffer T Wagner S Fernández B Helisch A Martin S Tribulova S Kuziel WA Bachmann G Schaper W 《Circulation research》2004,94(5):671-677
Arteriogenesis has been associated with the presence of monocytes/macrophages within the collateral vessel wall. Induced macrophage migration in vivo is driven by the binding of monocyte chemoattractant protein-1 (MCP-1, or CCL2 in the new nomenclature) to the CCR2-chemokine receptor on macrophages. To determine whether the CCL2-CCR2 signaling pathway is involved in the accumulation of macrophages in growing collateral vessels, we used mice that are deficient in CCR2 in a model of experimental arterial occlusion and collateral vessel growth. In an in vitro CCL2-driven chemotaxis assay, mononuclear cells isolated from wild-type BALB/c mice exhibited CCL2 concentration-dependent migration, whereas this migration was abolished in cells from CCR2(-/-) mice on a BALB/c genetic background. In vivo, blood flow recovery as measured by laser Doppler (LDI) and MRI (MRI) was impaired in CCR2(-/-) mice on either the BALB/c or C57BL/6 genetic backgrounds. Three weeks after femoral artery ligation, LDI perfusion ratio of operated versus nonoperated distal hindlimb in BALB/c wild-type mice increased to 0.45+/-0.06 and in CCR2(-/-) animals only to 0.21+/-0.03 (P<0.01). In C57BL/6 mice, ratio increased to 0.96+/-0.09 and 0.85+/-0.08 (P<0.05), respectively. MRI at 3 weeks (0.76+/-0.06 versus 0.62+/-0.01; P<0.05) and hemoglobin oxygen saturation measurements confirmed these findings. Active foot movement score significantly decreased and gastrocnemius muscle atrophy was significantly greater in CCR2(-/-) mice. Morphometric analysis showed a lesser increase in collateral vessel diameters in CCR2(-/-) mice. Importantly, the number of invaded monocytes/macrophages in the perivascular space of collateral arteries of CCR2(-/-) animals was dramatically reduced in comparison to wild-type mice. In conclusion, our results demonstrate that the CCR2 signaling pathway is essential for efficient collateral artery growth. 相似文献
56.
Mark D. Litt David M. Shafer Carlos R. Ibanez Donald L. Kreutzer Zeena Tawfik-Yonkers 《Pain》2009,145(1-2):160-168
The purpose of this study was to determine whether cognitive–behavioral treatment (CBT) operates by effecting changes in cognitions, affects, and coping behaviors in the context of painful episodes. Patients were 54 men and women with temporomandibular dysfunction-related orofacial pain (TMD) enrolled in a study of brief (6 weeks) standard conservative treatment (STD) or standard treatment plus CBT (STD + CBT). Momentary affects, pain, and coping processes were recorded on a cell phone keypad four times per day for 7 days prior to treatment, and for 14 days after treatment had finished, in an experience sampling paradigm. Analyses indicated no treatment effects on general retrospective measures of pain, depression, or pain-related interference with lifestyle at post-treatment. However, mixed model analyses on momentary pain and coping recorded pre- and post-treatment indicated that STD + CBT patients reported greater decreases in pain than did STD patients, significantly greater increases in the use of active cognitive and behavioral coping, and significantly decreased catastrophization. Analyses of experience sampling data indicated that post-treatment momentary pain was negatively predicted by concurrent active coping, self-efficacy, perceived control over pain, and positive-high arousal affect. Concurrent catastrophization was strongly predictive of pain. Active behavioral coping and self-efficacy reported at the prior time point (about 3 h previously) were also protective, while prior catastrophization and negative-high arousal mood were predictive of momentary pain. The results suggest that CB treatment for TMD pain can help patients alter their coping behaviors, and that these changes translate into improved outcomes. 相似文献
57.
No abstract available. 相似文献
58.
59.
60.
In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae. 总被引:1,自引:1,他引:0
下载免费PDF全文
![点击此处可从《Antimicrobial agents and chemotherapy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae. 相似文献