全文获取类型
收费全文 | 1137篇 |
免费 | 56篇 |
国内免费 | 79篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 43篇 |
妇产科学 | 8篇 |
基础医学 | 156篇 |
口腔科学 | 15篇 |
临床医学 | 159篇 |
内科学 | 212篇 |
皮肤病学 | 25篇 |
神经病学 | 68篇 |
特种医学 | 353篇 |
外科学 | 65篇 |
综合类 | 22篇 |
预防医学 | 28篇 |
眼科学 | 1篇 |
药学 | 84篇 |
肿瘤学 | 28篇 |
出版年
2023年 | 3篇 |
2021年 | 9篇 |
2020年 | 7篇 |
2019年 | 4篇 |
2018年 | 16篇 |
2017年 | 5篇 |
2016年 | 11篇 |
2015年 | 13篇 |
2014年 | 15篇 |
2013年 | 25篇 |
2012年 | 24篇 |
2011年 | 14篇 |
2010年 | 25篇 |
2009年 | 38篇 |
2008年 | 20篇 |
2007年 | 76篇 |
2006年 | 25篇 |
2005年 | 31篇 |
2004年 | 17篇 |
2003年 | 21篇 |
2002年 | 31篇 |
2001年 | 26篇 |
2000年 | 22篇 |
1999年 | 28篇 |
1998年 | 71篇 |
1997年 | 76篇 |
1996年 | 55篇 |
1995年 | 63篇 |
1994年 | 36篇 |
1993年 | 37篇 |
1992年 | 20篇 |
1991年 | 19篇 |
1990年 | 21篇 |
1989年 | 44篇 |
1988年 | 44篇 |
1987年 | 26篇 |
1986年 | 29篇 |
1985年 | 48篇 |
1984年 | 19篇 |
1983年 | 16篇 |
1982年 | 27篇 |
1981年 | 15篇 |
1980年 | 25篇 |
1979年 | 7篇 |
1978年 | 7篇 |
1977年 | 15篇 |
1976年 | 16篇 |
1975年 | 12篇 |
1970年 | 6篇 |
1969年 | 4篇 |
排序方式: 共有1272条查询结果,搜索用时 15 毫秒
21.
1 临床资料 患者 ,女 ,6 1岁 ,1999- 0 6 - 0 3日确诊为急性红白血病 (M6 ) .先后 4次住院 ,鉴定血型均为 O型 . 2 0 0 0 - 0 1- 2 2日复诊 ,正反鉴定表明 ,患者红细胞与抗 - B不凝集 ,与抗 - A凝集 ,血清中有抗 - B抗体 (表 1) ,吸收释放试验证实为 A型 (表2 ) .输 A型浓缩红细胞 2 μ,无不良反应 .表 1 血型正反鉴定试剂血清试剂红细胞标本抗 A 抗 B 抗 A+ B Ac Bc Oc被检红细胞 2 + -3+ ---自身血清 -3+ -表 2 吸收、放散试验被检 RBC吸收抗血清后上清被检 RBC吸收抗血清后释放液试剂细胞抗 A修正液抗 B修正液抗 A修正液抗… 相似文献
22.
综合疗法治愈狼疮性急性肾衰1例 总被引:3,自引:2,他引:1
1 病例报告 患者 ,女 ,6 0岁 ,因反复发热 2 5 a、全身性关节疼痛 2 3 a,双下肢水肿 2 mo,腹胀、尿少 1mo,于 1998- 10 - 2 0入院 .1975年患者出现发热 ,全身关节疼痛 ,四肢关节周围皮肤出现结节性红斑 ,触之疼痛 ,多次化验血沉 115 mm· h- 1 ,抗核抗体阴性 ,类风湿因子阳性 ,未找到狼疮细胞 ,诊断为“类风湿性关节炎”.1986年因上述症状复发再次入我院 ,多次检查后发现血抗核抗体 ( ) ,抗双链 DNA抗体 ( ) ,临床确诊为系统性红斑狼疮 (SL E) ,狼疮性肝炎 ,狼疮性胸膜炎 ,狼疮性肺炎 .经治疗好转 ,但上述症状反复发作 .此次上述症状复… 相似文献
23.
Diagnosis of an intrasellar pituitary microadenoma by CT may be difficult if the only finding is a small defect in enhancement. The diagnosis can be facilitated by dynamic CT of the pituitary gland in the coronal plane. This method permits visualization of the capillary bed of the pituitary, whose displacement ("tuft sign") could be an indication of the presence of a microadenoma. 相似文献
24.
Dural enhancement in pituitary macroadenomas 总被引:1,自引:0,他引:1
We describe the normal dural enhancement patterns of the sellar region and determine whether the duramater is affected by
pituitary macroadenomas. Dural enhancement appeared to be usually abnormal in 20 patients with pituitary macroadenoma compared
with 20 control patients, mainly at the planum sphenoidale and carotid sulcus. However dural changes are subtle and their
recognition requires knowledge of the normal enhancement patterns. Dural changes, reported in a variety of inflammatory and
infectious dural diseases and after surgery, are not specific and may be also seen in pituitary macroadenomas.
Received: 12 December 1998 Accepted: 3 November 1999 相似文献
25.
WG Mitchell H Lynn JF Bale MA Maeder SM Donfield B Garg AH Tilton JK Willis TP Bohan 《Pediatrics》1997,100(5):817-824
BACKGROUND: Boys and young men with hemophilia treated with factor infusions before 1985 had a substantial risk of acquiring the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome. This study was designed to assess the effects of HIV and hemophilia per se on neurological function in a large cohort of subjects with hemophilia, and to investigate the relationships between neurological disease and death during follow-up. METHODS: Three hundred thirty-three boys and young men (207 HIV seropositive and 126 HIV seronegative) were evaluated longitudinally in a multicenter, multidisciplinary study. Neurological history and examination were conducted at baseline and annually for 4 years. The relationship between neurological variables, HIV serostatus, CD4+ cell counts, and vital status at the conclusion of the study was examined using logistic regression models. RESULTS: The risks of nonhemophilia-associated muscle atrophy, behavior change, and gait disturbance increased with time in immune compromised HIV-seropositive subjects compared with HIV seronegative or immunologically stable HIV-seropositive subjects. The risk of behavior change in immune compromised HIV-seropositive hemophiliacs, for example, rose to 60% by year 4 versus 10% to 17% for the other study groups. Forty-five subjects (13.5%), all of whom were HIV seropositive, died by year 4. Subjects who died had had increased risks of hyperreflexia, nonhemophilia-associated muscle atrophy, and behavior change. CONCLUSIONS: These results indicate that immune compromised, HIV-seropositive hemophiliacs have high rates of neurological abnormalities over time and that neurological abnormalities were common among subjects who later died. By contrast, immunologically stable HIV-seropositive subjects did not differ from the HIV-seronegative participants. Hemophilia per se was associated with progressive abnormalities of gait, coordination, and motor function. 相似文献
26.
Dermoid tumours in children usually occur in two locations: at the anterior fontanelle and on the occipital squama. An exceptional site of origin for a posterior fossa dermoid cyst is the extradural space. There are only six previous cases of this situation reported in the literature. A series of 103 subscalp and calvarial masses in children were reviewed and three children are reported with extradural dermoids of the posterior fossa, which communicated with the skin through midline occipital dermal sinuses. All three children were seen after the rapid growth or the formation of an abscess in a previously noted occipital subcutaneous mass present since birth. Although computed tomography or magnetic resonance imaging showed the dermal sinus and the intracranial tumour, these studies were unable to ascertain the intradural or extradural nature of the tumours, their exact origin only being established at operation. Histopathological study showed preclinical signs of infection in the two patients that had not yet formed an abscess. It is suggested that early neurosurgical treatment of these neoplasms should be done to prevent the development of severe intracranial infection. The previously reported simplicity of surgical removal of occipital extradural dermoids was not confirmed in this series. 相似文献
27.
28.
29.
30.
Ex vivo development of functional human lymph node and bronchus-associated lymphoid tissue 下载免费PDF全文
Tirouvanziam R Khazaal I N'Sondé V Peyrat MA Lim A de Bentzmann S Fournié JJ Bonneville M Péault B 《Blood》2002,99(7):2483-2489
We introduce a novel in vivo model of human mucosal immunity, based on the implantation of human fetal bronchial mucosa and autologous peribronchial lymph node (PLN) in the severe combined immunodeficiency (SCID) mouse. In the SCID host, human fetal bronchi implanted alone retain macrophages and mast cells but lose T cells. In contrast, fetal bronchi co-implanted with PLN contain, in addition to macrophages and mast cells, numerous T cells and B cells, often clustered in intramucosal bronchus-associated lymphoid tissue (BALT). Functionally, bronchus-PLN cografts are able to mount robust alphabeta and gammadelta T-cell-mediated immune responses to Pseudomonas aeruginosa and 3,4-epoxy-3-methyl-1-butyl-diphosphate challenges. No other autologous lymphoid organ (bone marrow, thymus, liver) allows for BALT development in co-implanted bronchi, which suggests special ontogenetic and functional relations between extramucosal PLN and intramucosal BALT. Overall, the bronchus-PLN cograft appears as a promising model for human bronchial immune development and function. Our study is the first to document long-term ex vivo maintenance of functional human lymph nodes as native appendices to mucosal tissue. Our results, therefore, suggest a simple strategy for developing similar experimental models of human immune function in other mucosae. 相似文献