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781.
782.
The effect of diatrizoate on the chronic toxicity of chymopapain in the epidural space was studied. Chymopapain was injected epidurally into four monkeys; chymopapain plus diatrizoate meglumine, into four. In 3 months, neither group developed significantly more arachnoiditis than a control group of animals that had received epidural injections of physiologic saline. No synergistic effect of chymopapain and diatrizoate on the meninges was detected. 相似文献
783.
Joseph KC Huang Elizabeth F Shah Narayanan Vinodkumar MA Hegarty Robert A Greatorex 《Critical care (London, England)》2002,7(3):R13
Introduction
Use of the Bair Hugger forced-air patient warming system during prolonged abdominal vascular surgery may lead to increased bacterial contamination of the surgical field by mobilization of the patient's skin flora. 相似文献784.
Janet L. Oblinger Cynthia L. Boardman Allan J. Yates Richard W. Burry 《Journal of molecular neuroscience : MN》1993,20(2):103-113
The regulation of receptor tyrosine kinases (RTKs) is important in several cellular events, including proliferation, differentiation,
and apoptosis. Gangliosides are sialic acid-containing glycosphingolipids that can regulate RTK activity. The addition of
ganglioside GM1 to the medium of Swiss 3T3 fibroblasts inhibits both platelet-derived growth factor (PDGF)-mediated tyrosine
phosphorylation of PDGF receptor β (PDGFRβ) and receptor-mediated endocytosis. However, GM1 did not affect PDGF-mediated receptor
phosphorylation, neuritogenesis, or endocytosis in PC12 cells stably transfected with the gene for PDGFRβ. The ability of
GM1 to modulate PDGFRβ in 3T3 cells but not in transfected PC12 cells indicates a cell context-dependent response. We hypothesized
that this inhibition of PDGFRβ by GM1 must map to one or more domains of the receptor. Thus, a chimeric receptor was created
that possessed the extracellular and transmembrane domains of the nerve growth factor (NGF) receptor TrkA and the cytoplasmic
domain of PDGFRβ (TTβ). In 3T3 cells transfected with the TTβ construct, GM1 did not inhibit NGF-induced tyrosine phosphorylation
of the chimeric receptor or of Erk1/2 in this cell line. GM1 still inhibited PDGF-mediated tyrosine phosphorylation of endogenous
PDGFRβ and of Erk1/2 in Swiss TTβ cells. Thus, the cytoplasmic domain of PDGFRβ is not required for GM1-dependent inhibition
of PDGFRβ in 3T3 cells. This suggests that the inhibition of PDGFRβ by GM1 in Swiss 3T3 fibroblasts maps to either the extracellular
and/or transmembrane domain of PDGFRβ. 相似文献
785.
786.
787.
Ligamentum flavum: appearance on sagittal and coronal MR images 总被引:6,自引:0,他引:6
The appearance of the ligamentum flavum on sagittal and coronal magnetic resonance (MR) images has not been described in detail in the radiologic literature. The authors reviewed correlative MR images and anatomic sections obtained with a cryomicrotome in 20 cadavers in order to analyze anatomic relationships, variations, and progressive degenerative changes of the ligamentum flavum in the lumbar region. MR imaging showed the ligamentum flavum as an intermediate-signal-intensity structure on images obtained with short and long repetition times (TRs). Sagittal short TR images were effective for evaluating relationships between the ligamentum flavum, spinal canal, and nerve roots. Degenerative changes in the ligamentum flavum appeared as changes in shape or thickness of the ligaments on MR images. Calcification and fat infiltration, which were well depicted on anatomic sections, were not visualized on MR images. 相似文献
788.
789.
790.
Guidelines for blood utilization review 总被引:11,自引:0,他引:11
L Stehling ; NL Luban ; KC Anderson ; MH Sayers ; A Long ; S Attar ; SF Leitman ; SA Gould ; MS Kruskall ; LT Goodnough ; et al. 《Transfusion》1994,34(5):438-448
Hospitals are required by accrediting agencies to perform blood utilization review. Specific areas that must be addressed are the ordering, distribution, handling, dispensing, and administration of blood components. Monitoring the effects of transfusion on patients is also required. The format of the review process and the criteria for appropriate blood utilization must be developed by each institution. This article provides examples of areas that can be reviewed and procedures that may be used. However, the suggested laboratory values must not be interpreted as defining indications or criteria for transfusion. Each transfusion committee, or its equivalent, is responsible for developing its own institutional blood utilization procedures and audit criteria. Review and approval by the medical staff prior to implementation are essential. The procedures must also be reviewed and revised on a regular basis. 相似文献