椎管镜技术治疗腰椎间盘突出症并侧隐窝狭窄

目的 :探讨椎管镜技术治疗腰椎间盘突出症并侧隐窝狭窄的临床效果。方法 :采用显微内窥镜椎间盘切除系统治疗腰椎间盘突出症并侧隐窝狭窄 860例。结果 :临床疗效参照NaKai分级 ,70 9例获得随访 ,平均 2年 7个月 ,优 ,5 5 9例 ;良 ,12 7例 ;可 ,2 3例。结论 :椎管镜技术是治疗腰椎间盘疾病安全有效的方法 ,住院时间短 ,恢复快 ,但操作技术有待进一步提高。     

宫腔镜双极汽化电切术临床分析

目的 探讨宫腔镜双极汽化切割术的安全性和疗效。方法 术前宫腔镜诊断均为黏膜下肌瘤和肌壁间凸向宫腔肌瘤36例，在宫腔镜下施行双极汽化电切术。结果 手术成功率100％，手术时间10-70分钟，平均32分钟；出血量12-100ml，平均28ml；标本重15-42g，平均31g。术中、术后无并发症。术后满意率94．4％。结论 宫腔镜双极汽化切割术具有手术时间短、出血少、无并发症等优点，疗效满意。     

数字减影子宫输卵管造影术

目的:介绍和评价数字减影与自动高压注射器联合应用于子宫输卵管造影(HSG)。方法:自行设计造影用硅胶管使之能与自动高压注射器相联接,用40%泛影葡胺和数字减影方法作造影;随机抽取常规透视点片碘油造影片44份,数字减影泛影葡胺造影片50份进行对照分析。结果:两组比较:清晰度宫腔无显著性差异(P>0.05),输卵管有显著性差异(P<0.05);输卵管通畅率、血管或(和)淋巴管回流率有显著性差异(P<0.05)。盆腔涂布无显著性差异(P>0.05)。结论:采用数字减影与高压注射器行子宫输卵管造影能提高造影质量。     

Characteristics of manifest glaucoma at early stages

Intraocular pressures and optic disc hemorrhages were studied in all cases of manifest glaucoma detected in a defined population over a decade. High intraocular pressure was found to be an unreliable signat the detection of a glaucomatous visual field defect and an unusual finding 5–10 yearsbefore. The prevalence of optic disc hemorrhages at the detection of a glaucomatous visual field defect was 33%. All but 9 of 44 persons with manifest glaucoma were found to have had at least one optic disc hemorrhage at one time or another.     

手术示教系统的细节设计

手术示教系统已是一个较为成熟的教学系统,本文将根据现时流行的几种设计方案进行分析,并对设计过程和选材中遇到的一些细节问题提出一些意见.     

c-myc mRNA在成釉细胞瘤中的表达

目的:研究成釉细胞瘤(AB)和牙源性角化囊肿(OKC)中c-mycmRNA的表达,探讨c-myc在AB和OKC中的发生、发展及其生物学意义。方法:使用原位杂交法检测54例AB、16例OKC和7例口腔正常黏膜(NOM)组织中c-mycmRNA的表达,并将AB按原发、复发、恶变分组,结果使用χ2检验进行统计分析。结果:AB、OKC及NOM组织中c-mycmRNA的阳性表达率分别为81.5%(44/54)、75.0%(12/16)和14.3%(1/7),3组比较有显著性差异(χ2=15.488,P<0.05)。原发组AB中c-mycmRNA的阳性表达率为71.0%,复发组为94.7%,恶变组为100.0%,伴随原发、复发、恶变,差异有显著性(χ2=16.912,P﹤0.05)。结论:c-myc表达在AB的发生、发展中有重要作用;c-mycmRNA的表达与AB的临床生物学行为有关,伴随其生物学行为变化,c-mycmRNA表达增强;提示c-myc有可能成为评价预后的有效指标。     

18例青年人肺癌的CT表现与临床分析

目的：对青年人肺癌18例的CT表现与临床分析。方法：收集我院近5年肿瘤科、呼吸内科及门诊就诊的肺癌325例,经CT检查结合临床表现进行诊断、治疗和分析。结果：18例从起病到确诊时间为2 w至半年不等,平均2个月;其中,中央型肺癌10例,周围型肺癌8例。结论：近年来青年人肺癌发生率有上升趋势、应对青年人群定期体检,争取早诊断早治疗以提高青年人肺癌治疗效果。     

Association of the GNAS1 gene variant with hypertension is dependent on alcohol consumption.

The beta-adrenoceptor (beta-AR)-stimulatory guanine nucleotide-binding (Gs) protein system has been shown to play important roles in the cardiovascular system. The gene encoding the alpha-subunit of Gs proteins (GNAS1) is a candidate genetic determinant for hypertension. Because alcohol consumption is known to affect blood pressure partly through the beta-AR-Gs protein system, we examined the possible interaction between GNAS1 T393C polymorphism and drinking status in the association with hypertension in the present study. As a result, a non-significant but reasonable trend supporting the presence of an interaction was shown (p = 0.076). In line with this trend, the T393C polymorphism significantly interacted with drinking status in the association with systolic blood pressure (p = 0.028). Moreover, supporting the presence of an interaction, T allele carriers consistently had a higher probability of hypertension, higher systolic blood pressure, and higher diastolic blood pressure than CC homozygotes in non-drinkers and light drinkers. In contrast, CC homozygotes consistently had a higher probability of hypertension, higher systolic blood pressure, and higher diastolic blood pressure than T allele carriers in moderate to heavy drinkers. The present study also showed a significant interaction between the T393C polymorphism and drinking status in the association with pulse pressure (p = 0.026), reflected by a significant association between the T393C polymorphism and pulse pressure in moderate to heavy drinkers (p = 0.026). These findings may be helpful in conducting further molecular and biological studies on the relationship among the effects of alcohol, the beta-AR-Gs protein system, and hypertension.     

结直肠de novo癌的研究概况

近年来，随着内镜技术的发展，已能发现越来越多的微小和早期结直肠病变。部分报道曾描述了一种微小而极具侵袭性的结直肠癌，因其缺乏起源于腺瘤的证据，被称为“de novo癌（de novo carcinoma）”。这类肿瘤由于挑战了经典的腺瘤癌变途径而引起众多争议，但由于其所显示的独特生物学特性，也得到了各国学者的充分重视。本文将对de novo癌的概念、争议及其临床、分子生物学水平的特点进行初步概述。     

慢性多发性肌炎临床及病理分析

目的探讨慢性多发性肌炎的发病机制、临床和病理特征。方法回顾性分析95例慢性多发性肌炎患者临床表现、肌酶学和肌电图检查结果,总结肌肉病理学特征。结果慢性多发性肌炎以四肢近端肌无力、肌萎缩为主要表现,血清酶谱轻-中度增高,肌电图以肌源性损害为主,病理改变为灶性坏死、炎性细胞浸润与再生肌纤维共存。结论临床特点结合病理学检查有助于慢性多发性肌炎的诊断,多数患者激素治疗有效。