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971.
目的 评估宁波市手足口病经济负担。 方法 选取国家疾病监测信息报告管理系统中2011年宁波市报告的手足口病例,进行问卷调查和病历回顾,收集病例就医过程、相关费用和医疗保险等信息,估算手足口病例经济负担。 结果 共调查手足口病轻症病例106例,重症病例58例,死亡病例6例。2011年宁波市手足口病总体经济负担为3635.1万元,其中直接经济负担2181.2万元,间接经济损失1453.9万元。轻症、重症、死亡病例直接费用的中位数分别为1581、7419和21 533元,直接医疗费用的中位数分别为1431、6977和17 224元。参加至少一种医疗保险的病例占32.9%,医疗保险可为轻症、重症病例分别减轻38.2%和29.1%的直接医疗费用。 结论 手足口病给患者和社会均造成了较重的经济负担。提高医疗保险覆盖率、减少轻症病例住院比例将有助于减轻患者经济负担;控制和降低发病率,才能有效减轻手足口病对社会的经济负担。 相似文献
972.
973.
974.
975.
目的 通过对开放性骨折清创后创口分泌物的微生物培养结果,选择创口的闭合时机.方法 对182例开放性骨折患者均进行急诊清创,清创后进行创口分泌物培养.如果培养结果阳性,则再次清创后进行分泌物培养,直到培养结果阴性后才闭合创口.结果 182例开放性骨折患者总的深部感染率为5.5%,其中GustiloⅡ型骨折深部感染率为3.3%,Ⅲ型骨折感染率为7.9%.结论 与文献报道比较,该治疗方案深部感染率较低. 相似文献
976.
Haitao Li Tao Song Yingmei Shao Aili Tuergan Bo Ran Hao Wen 《Parasitology research》2013,112(6):2237-2243
The aim of this study was to investigate the clinical efficiency of chemotherapy for the treatment of human alveolar echinococcosis (AE). Twenty-four patients who suffered from late-stage AE were enrolled in this study. The classification of the disease stages was performed according to the PNM (parasite lesion, neighboring organ invasion, metastases) classification system established by the World Health Organization Informal Working Group on Echinococcosis and classification standards. Radical surgery (n?=?3), palliative surgery plus chemotherapy (n?=?11), and sole chemotherapy (n?=?10) were given, respectively. For those with AE metastasis with spleen and kidney, radical surgery was effective for the treatment. However, the treatment efficiency for those with AE metastasis to bone tissues was unfavorable. Significant improvement was noted in those with cerebral lesions after chemotherapy. Stable health conditions were observed in those with pulmonary lesions after chemotherapy. For those with liver lesion, long stable health conditions were noted after chemotherapy. However, surgical interventions were needed as the occurrence of bile duct complications. With regards to the other lesions, radical surgeries were recommended. Satisfactory treatment outcomes were obtained in those with AE after chemotherapy. 相似文献
977.
978.
The combination of point and linear features can strengthen the robustness and accuracy of the registration of image and light detection and ranging (LiDAR) point clouds. The key point of registration is the establishment of a geometric transformation model. This paper proposes a quadratic-constraint-based geometric transformation (QCGT) line model, in which combines point and linear features, and simultaneously takes the orientation and position of the line into account. The coordinates of points and lines uniformly described by line model in the same mathematical framework are used to construct a coplanarity equation. The data set of International Society for Photogrammetry and Remote Sensing (ISPRS) test project is used, and the robustness and efficiency of QCGT is verified by progressive experiments. The experimental results have shown that QCGT is feasible and can achieve more reliable results than the traditional method. The geometric constraints of the line model are enhanced due to the quadratic constraint, solving the problems of the different mathematical representation of geometric features and reducing the complexity of transformation. 相似文献
979.
目的:探讨晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)外周血循环肿瘤DNA(circulating tumor DNA,ctDNA)表皮生长因子受体(epidermal growth factor receptor,EGFR)突变与EGFR酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)治疗疗效的相关性。方法:利用突变扩增阻滞系统(amplification refractory mutation system,ARMS)法检测50例NSCLC患者外周血ctDNA EGFR突变,其中27例进行组织与ctDNA配对检测。给予TKI治疗一月后进行疗效评价。对ctDNA EGFR突变与患者的临床因素、疗效相关性进行分析,并比较ctDNA与肿瘤组织EGFR突变的一致性。结果:患者性别、年龄、PS评分、病理类型、吸烟史与ctDNA EGFR突变无明显相关性(P>0.05)。ctDNA EGFR突变组客观缓解率(76.5%)、疾病控制率(100%)均高于野生型组(30.3%,60.6%)(P<0.05)。生存分析结果显示:ctDNA EGFR突变组无进展生存期(12个月)较野生型组长(4个月)(P<0.05)。27例配对检测结果显示:ctDNA与肿瘤组织EGFR突变一致率为66.7%(18/27,Kappa=0.400,P<0.05)。无进展生存期:ctDNA(23个月)/肿瘤组织(12个月)EGFR突变组均长于野生型组(2个月/1个月)(P<0.05)。结论:晚期NSCLC外周血ctDNA EGFR突变患者TKI治疗有效率高,ctDNA与肿瘤组织EGFR突变一致性好,作为肿瘤组织的替代检测标本是可行的。 相似文献
980.
Epilepsy is known as one of the most frequent neurological diseases, characterized by an enduring
predisposition to generate epileptic seizures. Oxidative stress is believed to directly participate in pathways
leading to neurodegeneration, which serves as the most important propagating factor, leading to the epileptic
condition and cognitive decline. Moreover, there is also a growing body of evidence showing the disturbance
of antioxidant system balance and consequently increased production of reactive species in patients with
epilepsy. A meta-analysis, conducted in the present review confirms an association between epilepsy and
increased lipid peroxidation. Furthermore, it was also shown that some of the antiepileptic drugs could potentially be
responsible for additionally increased lipid peroxidation. Therefore, it is reasonable to propose that during the epileptic
process neuroprotective treatment with antioxidants could lead to less sever structural damages, reduced epileptogenesis
and milder cognitive deterioration. To evaluate this hypothesis studies investigating the neuroprotective therapeutic
potential of various antioxidants in cells, animal seizure models and patients with epilepsy have been reviewed. Numerous
beneficial effects of antioxidants on oxidative stress markers and in some cases also neuroprotective effects were observed
in animal seizure models. However, despite these encouraging results, till now only a few antioxidants have been further
applied to patients with epilepsy as an add-on therapy. Based on the several positive findings in animal models, a strong
need for more carefully planned, randomized, double-blind, cross-over, placebo-controlled clinical trials for the evaluation
of antioxidants efficacy in patients with epilepsy is warranted. 相似文献