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61.
常咯啉在实验性心律失常狗的药代动力学-药效动力学分析 总被引:1,自引:0,他引:1
用Harris冠脉结扎法诱发的心律失常狗研究常咯啉药代动力学-药效动力学。7只狗按83.33μg·kg-1·min-1静脉滴注60min,在给药期间和停药后不同时间记录ECG及测定血药浓度。C-T数据用药代程序计算药代参数;药效数据用药代-药效同步分析模型计算药效动力学参数,K10, T1/2,Vd,Cl分别为0.0087min-1,78.03min,40.55ml·kg-1和0.421ml·kg-1·min-1;KeO和Ce(50)分别为0.0048min-1和2.01μg·ml-1. 相似文献
62.
Tendon echogenicity: ex vivo study 总被引:2,自引:0,他引:2
Recent publications discussing the echogenicity of normal tendon have described it variously as hyperechoic or hypoechoic. Since the echogenicity of tendon has been used to define normality and abnormality, certain knowledge of the normal echogenicity of tendon is crucial. Fresh tendon and muscle from beef hock was scanned with sector- and linear-array-transducer imaging at multiple angles and distances. The echogenicity of tendon was found to be very angle-dependent, a characteristic known as anisotropy. Scanned perpendicular to its long axis with a linear-array transducer, tendon was significantly more echogenic than muscle. With a change in angle, echogenicity of tendon decreased relative to that of muscle (the echogenicity of muscle remained the same), becoming isoechoic at angles of 2 degrees -7 degrees and hypoechoic at greater angles. Tendon studied with a sector transducer exhibited varying echogenicity. If echogenicity is used as a diagnostic criterion, the angle of the interrogating ultrasound beam must be very specifically defined. 相似文献
63.
Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFN gamma in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan. 相似文献
64.
A case of mixed connective tissue disease (MCTD) is presented in which mediastinal lymphadenopathy was the most prominent radiological finding detected by plain chest radiographs and computed tomography. Pulmonary arterial hypertension, which is a rare and often fatal complication of MCTD, also developed in this patient. 相似文献
65.
Dieli F; Asherson GL; Tomonari K; Sireci G; Caccamo N; Salerno A 《International immunology》1997,9(1):1-8
We have recently demonstrated a remarkable selection of in vitro
cultivated, TNP-specific polyclonal T cell lines for the expression of a
TCR beta chain encoded by the V beta 8.2 gene. The goal of the present
study was to analyse V alpha usage in V beta 8.2 T cells responsive to TNP,
using TNP-specific T cell lines derived from three common strains of mice,
as well as from V beta 8.2 transgenic mice. Results indicate that in vitro
TNP stimulation of T cells from TNP- immune mice results in significant
skewing of V alpha usage among responding V beta 8.2+ T cells, with
overexpression observed for V alpha 3.2 and V alpha 8. These results
indicate that V alpha expression influences recognition of TNP by T cells,
and suggest that the hapten TNP might be recognized like typical peptide
antigens by combinatorial TCR alpha and beta contact sites.
相似文献
66.
Rosen BR; Fleming DM; Kushner DC; Zaner KS; Buxton RB; Bennet WP; Wismer GL; Brady TJ 《Radiology》1988,169(3):799
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