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41.
Zhao Y Kuge Y Zhao S Morita K Inubushi M Strauss HW Blankenberg FG Tamaki N 《European journal of nuclear medicine and molecular imaging》2007,34(11):1747-1755
Purpose
99mTc-annexin A5, a marker of ongoing apoptosis, and 18F-FDG, a marker of the increased metabolism of inflammatory cells, are supposed to be useful in the detection of metabolically
active atheroma. This study reports a comparison of the intralesional distribution of these tracers in relation to lesion
development in ApoE−/− mice.
Methods Male ApoE−/− mice (n = 12–14/group) were maintained on a Western-type diet after the age of 5 weeks. At 25 weeks, 99mTc-annexin A5 or 18F-FDG was injected and the aortas were harvested for autoradiography (ARG) and Oil Red O staining. Regional radioactivity
accumulation was compared in relation to the Oil Red O staining score (ranging from 0 to 3, a semiquantitative parameter for
evaluating lesion development).
Results Both 99mTc-annexin A5 and 18F-FDG showed preferential uptake into atherosclerotic lesions, with higher uptake levels for 18F-FDG (mean, 56.07 %ID×kg/m2) than for 99mTc-annexin A5 (mean, 10.38 %ID×kg/m2). The regional uptake levels of each tracer correlated with the Oil Red O staining score (r = 0.65, p < 0.05 for 99mTc-annexin A5; r = 0.56, p < 0.05 for 18F-FDG). The uptake ratios of advanced lesions (score >0.5) to early lesions (score <0.5) were significantly higher for 99mTc-annexin A5 than for 18F-FDG (f = 4.73, p = 0.03).
Conclusion Both 99mTc-annexin A5 and 18F-FDG accumulate in atherosclerotic lesions and correlate with the severity of each lesion. The higher absolute uptake levels
of 18F-FDG may be advantageous for lesion detection, whereas the preferential uptake of 99mTc-annexin A5 in advanced lesions may be a useful indicator of late-stage lesions or vulnerable plaque transformation. 相似文献
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FG Rheinl.-Pfalz 《MedR Medizinrecht》2008,20(11):581-582
Der wirtschaftliche Vorteil einer Vertragsarztzulassung stellt kein gesondert zu bewertendes Wirtschaftsgut
dar, sondern einen wertbildenden Faktor des Wirtschaftsguts “Praxiswert” im Rahmen des Gesamtkaufpreises
zum Erwerb der Vertragsarztpraxis. 相似文献
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Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest 《World journal of gastroenterology : WJG》2015,21(45):12742-12756
The sequence of events associated with the development of gastric cancer has been described as “the gastric precancerous cascade”. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori (H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the most relevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and miRNAs in this context. 相似文献
47.
Kidney injury and mortality after transcatheter aortic valve implantation in a routine clinical cohort
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Dr. M. Seiffert H. Treede D. Boehm K. Overlack S. Blankenberg H. Reichenspurner 《Zeitschrift für Herz-, Thorax- und Gef??chirurgie》2012,26(5):312-315
In order to meet the complex requirements of novel cardiovascular therapies, structural prerequisites are required. At the University Heart Center Hamburg, all cardiovascular departments are being combined in one building to allow for pooling of resources and constant interdisciplinary discussion of cases. Patient-oriented treatment through a heart team is being facilitated by a common budget shared by the departments of the heart center. Additionally, postgraduate training is being refined to meet evolving challenges on future cardiac surgeons. 相似文献
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