全文获取类型
收费全文 | 4438篇 |
免费 | 336篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 66篇 |
儿科学 | 175篇 |
妇产科学 | 102篇 |
基础医学 | 726篇 |
口腔科学 | 110篇 |
临床医学 | 330篇 |
内科学 | 1154篇 |
皮肤病学 | 122篇 |
神经病学 | 370篇 |
特种医学 | 143篇 |
外科学 | 661篇 |
综合类 | 17篇 |
一般理论 | 3篇 |
预防医学 | 217篇 |
眼科学 | 105篇 |
药学 | 244篇 |
中国医学 | 11篇 |
肿瘤学 | 234篇 |
出版年
2023年 | 19篇 |
2022年 | 50篇 |
2021年 | 120篇 |
2020年 | 60篇 |
2019年 | 125篇 |
2018年 | 138篇 |
2017年 | 79篇 |
2016年 | 89篇 |
2015年 | 106篇 |
2014年 | 137篇 |
2013年 | 179篇 |
2012年 | 286篇 |
2011年 | 298篇 |
2010年 | 158篇 |
2009年 | 156篇 |
2008年 | 246篇 |
2007年 | 245篇 |
2006年 | 235篇 |
2005年 | 239篇 |
2004年 | 239篇 |
2003年 | 227篇 |
2002年 | 196篇 |
2001年 | 183篇 |
2000年 | 196篇 |
1999年 | 136篇 |
1998年 | 55篇 |
1997年 | 45篇 |
1996年 | 39篇 |
1995年 | 24篇 |
1994年 | 23篇 |
1993年 | 20篇 |
1992年 | 66篇 |
1991年 | 45篇 |
1990年 | 41篇 |
1989年 | 30篇 |
1988年 | 29篇 |
1987年 | 37篇 |
1986年 | 17篇 |
1985年 | 19篇 |
1984年 | 22篇 |
1983年 | 19篇 |
1982年 | 12篇 |
1979年 | 12篇 |
1977年 | 12篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1973年 | 6篇 |
1971年 | 6篇 |
1970年 | 7篇 |
1968年 | 6篇 |
排序方式: 共有4790条查询结果,搜索用时 15 毫秒
71.
72.
Blanco JA Javier G Fraile M Isnard RM Castellví A López P Riba J Prats J Casasa JM 《Cirugía pediátrica : organo oficial de la Sociedad Espa?ola de Cirugía Pediátrica》1999,12(3):127-128
Radio-guided surgery is a new technique which can provide benefits for pediatric oncology, as in our patient with neuroblastoma in stage IV, that after a chemotherapy, surgical, radiotherapy and autologous bone marrow transplant treatment kept showing, at 2 years, residual tumoral fragments and increase of catecholamines. Radio-guided surgery allowed an easy and exact location. This technique decreases surgery time and let us find residual tumoral tissue no matter how small. With radio-guided surgery we can obtain higher survival and even cure the patient. 相似文献
73.
de Agustín JC Zabala JI Zunzunegui JL Medrano C Maroto E Maroto C Blanco T Luque-Mialdea R Cerdá J Aguilar F Vázquez J 《Cirugía pediátrica : organo oficial de la Sociedad Espa?ola de Cirugía Pediátrica》1999,12(1):30-32
The haemodynamic changes produced by laparoscopic surgery in children have been evaluated. A transesophageal echocardiographic study on 13 patients (7 males and 6 females, 10.8 +/- 2.7 years old) has been performed before, during and after peritoneal CO2 gas insufflation. A change on the Doppler waves pattern of the infradiaphragmatic veins along with an increase in blood flow velocity were observed. Pulmonary veins suffered minimal changes showing an increase on either the systolic pressure and on atrial contraction. Diastolic retrograde flow in aorta reflected an increase in peripheral vascular resistance. Cardiac output increased minimally. All haemodynamic changes returned to basal after gas peritoneal desufflation. These data show that laparoscopic surgery could produce important cardiac derangements in children with ventricular dysfunction or in patients presenting left ventricular outlet obstruction. In these patients laparoscopic surgery might be precluded. 相似文献
74.
75.
C. Ciacci MD R. Zarrilli MD PhD V. Ricci MD PhD A. De Luca MD G. Mazzacca MD C. Del Vecchio Blanco MD Dr. M. Romano MD 《Digestive diseases and sciences》1996,41(5):972-978
Gastric mucosal cell migration and proliferation are crucial events in the repair of gastric mucosal erosions. This study was designed to test the hypothesis that the H2 blockers roxatidine and ranitidine might stimulate migration and proliferation of gastric mucous cells derived from a human well-differentiated gastric adenocarcinoma cell line (MKN 28 cells)in vitro, in conditions independent of systemic factors and of acid inhibition. Confluent monolayers of MKN 28 cells were wounded with a razor blade and were then incubated with roxatidine or ranitidine. The number of cells migrating to the damaged area was determined 24 hr later. Cell proliferation was assessed by means of [3H]thymidine uptake and cell counts after incubation with roxatidine or ranitidine. Neither H2 antagonist significantly stimulated cell migration. On the other hand, cell proliferation was dose-dependently and significantly enhanced by incubation with roxatidine and ranitidine. Exogenous administration of TGF- significantly stimulated MKN 28 cell division. However, incubation with roxatidine or ranitidine did not increase the steady-state mRNA expression of TGF- or EGFR as assessed by northern blot analysis. Based on thesein vitro findings, we postulate that the ulcer healing effect of these H2 antagonistsin vivo might be due in part to stimulation of gastric mucosal cell proliferation.Data from this paper have been presented in part at the 1995 meeting of the American Gastroenterological Association and published in abstract form in Gastroenterology 108:A72, 1995. 相似文献
76.
Fernández López F Puñal Rodríguez JA Blanco Parra MA Rodríguez Segade F Romero R Varo Pérez E 《Actas urologicas espa?olas》2000,24(7):584-585
Over the last decade kidney transplantation has become a common therapeutic procedure for patients with end-stage renal diseases. Between 1988 and 1998 donors rate per million population has dramatically increased in our environment, thus providing us with more chances to offer kidney transplantation to a larger number of patients. The technico-surgical difficulties that have to be faced however, are increasingly frequent and require a search for new approaches and innovative changes to the usual surgical techniques for our patient's benefit. 相似文献
77.
78.
Rosa Caputo Concetta Tuccillo Barbara A Manzo Raffaele Zarrilli Giampaolo Tortora Camillo Del Vecchio Blanco Vittorio Ricci Fortunato Ciardiello Marco Romano 《Clinical cancer research》2003,9(6):2015-2021
PURPOSE: Helicobacter pylori causes gastric damage and is involved in gastric carcinogenesis. Vascular endothelial growth factor (VEGF) plays a major role in gastric mucosa repair and is overexpressed in gastric cancer. We investigated: (a) whether H. pylori, and in particular H. pylori VacA toxin, affected VEGF expression in gastric epithelial cells in culture; and (b) the signal transduction pathway involved in any effect exerted by H. pylori. EXPERIMENTAL DESIGN: MKN-28 cells were incubated with uninoculated BCF (control) or with BCF obtained from VacA-producing wild-type H. pylori 60190 strain or from its isogenic mutant 60190:v1, specifically lacking vacA gene in the presence or absence of ZD 1839, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, PD098059, a selective inhibitor of mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase, the kinase responsible for ERK phosphorylation, or SC-236, a selective inhibitor of cyclooxygenase (COX)-2 for 24-48 h. RESULTS: (a) Toxigenic H. pylori up-regulated VEGF mRNA and protein expression and caused a 2.5-fold increase in VEGF release compared with control, whereas nontoxigenic H. pylori did not; (b) H. pylori VacA toxin-induced up-regulation of VEGF was counteracted by selective inhibition of EGFR tyrosine kinase; (c) toxigenic H. pylori activated the ERK/MAP kinase cascade, and inhibition of MAP kinase activation counteracted H. pylori-induced VEGF up-regulation; (d) toxigenic H. pylori up-regulated COX-2 expression, and this effect was counteracted by blockade of EGFR tyrosine kinase; and (e) COX-2 selective inhibition counteracted H. pylori-induced up-regulation of VEGF. CONCLUSION: (a) H. pylori up-regulates VEGF expression in gastric epithelial cells; and (b) this effect is specifically related to VacA toxin and seems to depend on the activation of an EGFR-, MAP kinase-, and COX-2-mediated pathway. 相似文献
79.
Wolff-Parkinson-White syndrome is important for the anesthesiologist because the sudden development of tachyarrhythmias may result in deleterious hemodynamic changes. We describe an episode of reciprocating tachycardia triggered by the insertion of the guide wire during central venous cannulation in a patient with this syndrome. 相似文献
80.
The authors describe a 3-day-old newborn admitted with signs of intestinal obstruction caused by solitary intestinal fibromatosis (SIF). This is a very rare lesion, which has an excellent prognosis. The differential diagnosis of bilious vomiting in a neonate caused by other than tumorous processes in the neonatal intestine is extensive. Probably this kind of lesion is more frequent in the neonatal period than thought until now but underdiagnosed because of the difficulty of diagnosis. Therapy of choice is wide local excision, and prognosis is excellent. 相似文献