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Yaron Arbel Dennis T. Ko Andrew T. Yan Warren J. Cantor Akshay Bagai Maria Koh Maria Eberg Mary Tan David Fitchett Bjug Borgundvaag John Ducas Michael Heffernan Laurie J. Morrison Anatoly Langer Vladimir Dzavik Shamir R. Mehta Shaun G. Goodman 《The Canadian journal of cardiology》2018,34(6):736-743
Background
The Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI) demonstrated superiority of routine early coronary angiography (and percutaneous coronary intervention [PCI]) compared with standard therapy in fibrinolytic-treated patients with ST-segment elevation myocardial infarction (STEMI) at 30 days. The aim of the current study was to evaluate the long-term (>7 year) effects of an early invasive strategy.Methods
We linked the study cohort and administrative datasets to assess long-term follow-up status including repeat procedures, hospitalizations, and major adverse cardiovascular events (MACE). Kaplan-Meier and Cox regression analysis were used to evaluate the relationship between randomized treatment and long-term adverse outcomes.Results
A total of 881 patients had long-term follow-up and were included in our study. After a mean follow-up of 7.8 years, there were no significant differences in death, myocardial infarction (MI), unstable angina, stroke, transient ischemic attack (TIA), or heart failure admissions (hazard ratio [HR] 0.91; 95% confidence interval [CI] 0.73–1.13]; P = 0.41) between those randomized to an early invasive vs standard treatment strategy. Following the index hospitalization, there were no significant difference in the rates of coronary revascularization between the early invasive and the standard therapy groups (81 [19.3%] vs 76 [17.9%]; P = 0.61).Conclusions
Despite the short-term benefit and safety of an early invasive strategy in patients with STEMI receiving fibrinolysis, no statistically significant differences in MACE were observed over 7.8 years. 相似文献22.
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Bjug Borgundvaag PhD MD CCFP Fernanda Bellolio MD MSc Isabelle Miles MD Evan S. Schwarz MD Sameer Sharif MD MSc Mark K. Su MD MPH Kevin Baumgartner MD David B. Liss MD Hasan Sheikh MD MPA Jody Vogel MD MSc MSW Emily B. Austin MD Suneel Upadhye MD MSc Michelle Klaiman MD FRCPC DABAM Robert Vellend Anna Munkley Christopher R. Carpenter MD MSc 《Academic emergency medicine》2024,31(5):425-455
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Gregory Saito Jessica Thom Yanliang Wei Piraveina Gnanasuntharam Pirasanya Gnanasuntharam Nathan Kreiswirth Barbara Willey Michelle Loftus Catherine Varner Vanessa Porter Allison McGeer Bjug Borgundvaag 《The Canadian Journal of Infectious Diseases & Medical Microbiology》2013,24(3):e57-e60
BACKGROUND:
Methicillin-resistant Staphylococcus aureus (MRSA) acquired in the community, otherwise known as community-acquired MRSA, has emerged rapidly in recent years. Colonization with MRSA has been associated with an increased risk of symptomatic and serious infections and, in some settings, health care workers (HCWs) exhibit a higher prevalence of MRSA colonization.OBJECTIVE:
To determine MRSA colonization in emergency department (ED) HCWs in the setting of a moderate prevalence of MRSA in skin and soft tissue infections.METHODS:
The present study was conducted at a downtown ED in Toronto, Ontario. ED HCWs completed a brief questionnaire and swabs were taken from one anterior nare, one axilla and any open wounds (if present). Swabs were processed using standard laboratory techniques.RESULTS:
None of the 89 staff (registered nurses [n=55], physicians [n=15], other [n=19]) were MRSA positive and 25 (28.1%) were colonized with methicillin-susceptible S aureus.CONCLUSIONS:
Contrary to common belief among HCWs and previous studies documenting MRSA colonization of HCWs, MRSA colonization of this particular Canadian ED HCW cohort was very low and similar to that of the local population. 相似文献27.
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Maunder RG Lancee WJ Balderson KE Bennett JP Borgundvaag B Evans S Fernandes CM Goldbloom DS Gupta M Hunter JJ McGillis Hall L Nagle LM Pain C Peczeniuk SS Raymond G Read N Rourke SB Steinberg RJ Stewart TE VanDeVelde-Coke S Veldhorst GG Wasylenki DA 《Emerging infectious diseases》2006,12(12):1924-1932
Healthcare workers (HCWs) found the 2003 outbreak of severe acute respiratory syndrome (SARS) to be stressful, but the long-term impact is not known. From 13 to 26 months after the SARS outbreak, 769 HCWs at 9 Toronto hospitals that treated SARS patients and 4 Hamilton hospitals that did not treat SARS patients completed a survey of several adverse outcomes. Toronto HCWs reported significantly higher levels of burnout (p = 0.019), psychological distress (p<0.001), and posttraumatic stress (p<0.001). Toronto workers were more likely to have reduced patient contact and work hours and to report behavioral consequences of stress. Variance in adverse outcomes was explained by a protective effect of the perceived adequacy of training and support and by a provocative effect of maladaptive coping style and other individual factors. The results reinforce the value of effective staff support and training in preparation for future outbreaks. 相似文献
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Catherine Varner Howard Ovens Eric Letovsky Bjug Borgundvaag 《Canadian family physician Médecin de famille canadien》2012,58(7):e385-e389