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91.
OBJECTIVE: The goal of this study was to investigate the clinical and paraclinical features, treatment, and outcomes of patients with multiple sclerosis (MS) and coexisting spinal cord compression secondary to either cervical spondylosis or cervical disc disease. Patients with MS commonly experience neurological disabilities that present as myelopathy associated with bladder dysfunction. For some patients with MS, however, this neurological deterioration may result from coexisting spinal cord compression attributable to either spondylosis or a herniated disc. Overlapping symptoms of the two conditions do not allow clear clinical determination of the underlying cause of worsening. METHODS: Patients with MS who underwent cervical decompression surgery were selected. Medical records were retrospectively reviewed, to collect data on their pre- and postoperative clinical courses. RESULTS: Nine women and five men with definite MS were selected for cervical decompression surgery to treat neurological deterioration considered to be at least partially attributable to spinal cord compression. The most common symptoms were progressive myelopathy (n = 13), neck pain (n = 11), and cervical radiculopathy (n = 10). Bladder dysfunction was notably absent among these patients with MS with moderate disabilities. Surgical intervention was frequently delayed because the neurological deterioration was initially thought to be attributable to MS. The majority of patients experienced either improvement or stabilization of their preoperative symptoms in the immediate postoperative period; three subjects (21%) maintained this improvement after a mean follow-up period of 3.8 years. No MS relapses, permanent neurological worsening, or serious complications resulting from surgery or general anesthesia were noted. CONCLUSION: Carefully selected patients with MS and cervical spinal cord compression secondary to either spondylosis or disc disease may benefit from surgical decompression, with minimal associated morbidity. Clinical features (especially neck pain and cervical radiculopathy) and magnetic resonance imaging may assist clinicians in differentiating between the two conditions and may guide appropriate treatment without undue delay. 相似文献
92.
HPLC测定消食止泻散中橙皮苷的含量 总被引:5,自引:0,他引:5
赵彩云 《现代中药研究与实践》2003,17(1):37-38
目的 建立消食止泻散中橙皮苷的含量测定方法。方法 超声提取 ,HPL C测定消食止泻散中橙皮苷的含量。 C1 8柱 ,乙腈 -水 -磷酸 (180∶ 82 0∶ 0 .1)为流动相 ,检测波长为 2 83nm,柱温 :2 8℃。结果 橙皮苷含量测定的线性范围为 0 .197μg~ 1.182μg,r=0 .9999,n=6 ,平均加样回收率为 99.8 ,RSD为 1.3%。结论 本方法准确 ,简便 ,快速 ,可用于消食止泻散的质量控制。 相似文献
93.
CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC,RTOG consensus guidelines. 总被引:25,自引:0,他引:25
Vincent Grégoire Peter Levendag Kian K Ang Jacques Bernier Marijel Braaksma Volker Budach Cliff Chao Emmanuel Coche Jay S Cooper Guy Cosnard Avraham Eisbruch Samy El-Sayed Bahman Emami Cai Grau Marc Hamoir Nancy Lee Philippe Maingon Karin Muller Hervé Reychler 《Radiotherapy and oncology》2003,69(3):227-236
BACKGROUND AND PURPOSE: The appropriate application of 3-D CRT and IMRT for HNSCC requires a standardization of the procedures for the delineation of the target volumes. Over the past few years, two proposals--the so-called Brussels guidelines from Grégoire et al., and the so-called Rotterdam guidelines from Nowak et al.--emerged from the literature for the delineation of the neck node levels. Detailed examination of these proposals however revealed some important discrepancies. MATERIALS AND METHODS: Within this framework, the Brussels and Rotterdam groups decided to review their guidelines and derive a common set of recommendations for delineation of neck node levels. This proposal was then discussed with representatives of major cooperative groups in Europe (DAHANCA, EORTC, GORTEC) and in North America (NCIC, RTOG), which, after some additional refinements, have endorsed them. The objective of the present article is to present the consensus guidelines for the delineation of the node levels in the node-negative neck. RESULTS AND CONCLUSIONS: First a short discussion of the discrepancies between the previous Brussels and the Rotterdam guidelines is presented. The general philosophy of the consensus guidelines and the methodology used to resolve the various discrepancies are then described. The consensus proposal is then presented and representative CTVs that are consistent with these guidelines are illustrated on CT sections. Last, the limitations of the consensus guidelines are discussed and some concerns about the direct applications of these guidelines to the node-positive neck and the post-operative neck are described. 相似文献
94.
HPLC法测定复方阿替洛尔片中阿替洛尔与硝苯地平的含量 总被引:1,自引:0,他引:1
目的:采用高效液相色谱法考察并建立测定复方阿替洛尔片中阿替洛尔与硝苯地平含量的方法。方法:色谱柱为Phe-nomenex—ODS 3柱(250 mm×4.60 mm,5 μm),甲醇-水-磷酸盐缓冲溶液(取磷酸二氢钾6.8 g,加水1000 mL溶解后,用磷酸调pH至3.0)-庚烷磺酸钠适量摇匀(65:35:3:0.13 g=V:V:V:W)为流动相,流速为1.0 mL·min~1,检测波长为240 nm,进样量为10μL。结果:阿替洛尔的线性范围为10-250μg·mL-1(r=0.9999),硝苯地平的线性范围为4—100 μg·mL-1(r=1.0000),平均回收率分别为99.45%和99.51%。结论:本法精密度好,结果准确可靠,适用于该复方制剂的质量检验分析。 相似文献
95.
Kobayashi N Ito M Nakamura J Cai J Cao C Hammel JM Fox IJ 《Transplantation proceedings》2000,32(7):2287-2288
96.
97.
肾上腺素诱导兔血小板聚集的实践与理论探讨 总被引:1,自引:0,他引:1
目的创建以Adr诱导兔血小板聚集的方法,并对受体分子特性作初步探讨。方法以高K+缓冲液等取代兔PRP中血浆,以Adr诱导聚集,以Apyr证实结果。结果兔血小板悬浮于高K+缓冲液时Adr能单独诱导真正的聚集。结论由此推测血小板膜上α2肾上腺素受体分子可能为由两种亚单位组成:促聚亚单位和辅助亚单位。人辅助亚单位当Adr浓度高达聚集阈值以上时可被激活,与促聚亚单位结合为活性的二聚体,与Adr进一步结合发生聚集作用。兔辅助亚单位则还需要高K+方能被激活 相似文献
98.
氯硝安定与安定溶液直肠给药用于惊厥急救的对照研究 总被引:21,自引:1,他引:21
目的以安定为对照,探讨氯硝安定溶液直肠给药对惊厥急救的实用价值。方法在28例儿童中对比观察直肠注入氯硝安定与安定溶液的吸收速度和对脑电活动的影响,并比较两药对大鼠实验性惊厥的疗效。结果氯硝安定与安定溶液均能从直肠迅速吸收,皆于用药5分钟后达有效血浓度,分别于3~8分钟及2~8分钟对脑电活动产生显著影响,明显抑制癫痫样波发放,使美解眠诱发的惊厥致死率从对照组的70%降为0。结论氯硝安定与安定溶液直肠给药,均能作为小儿惊厥抢救的有效措施。 相似文献
99.
喉腔及喉咽部平滑肌肉瘤3例报告 总被引:3,自引:0,他引:3
为了解发生于喉腔及喉咽部的平滑肌肉瘤的临床特点,报告1例喉咽部平滑肌肉瘤和2例喉腔平滑肌肉瘤患者早期症状都不明显,且无特异性,临床表现与该部常见鳞癌极为相似,术前明确诊断有一定困难。 相似文献
100.
咽旁间隙肿瘤及手术入路 总被引:8,自引:2,他引:8
为探讨咽旁间隙肿瘤的手术方法及入路的选择。报告66例经各种手术入路治疗的良、恶性肿瘤。结果表明,经颈或经颈合并下颌及正中裂开外旋入路较之其他几种手术入路具有手术适应证广、安全、术后并发症少等优点。认为经颈或经颈合并下颌正中裂开外旋入路是一种安全、彻底切除咽旁间隙原发肿瘤效果最好的入路。 相似文献