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51.
We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Multiple lines of evidence indicate that 10E5 binds to platelet membrane glycoproteins IIb and/or IIIa. Because it has been reported that platelets treated with chymotrypsin aggregate when fibrinogen is added, we tested the effect of 10E5 antibody on chymotrypsin-induced fibrinogen binding and platelet aggregation. Aspirin-treated human platelets were washed in modified Tyrode's buffer (pH 7.5), incubated for 5 minutes at 22 degrees C with 300 micrograms/mL chymotrypsin, and washed again. The amount of 10E5 antibody bound to these platelets (37,232 +/- 2,928 molecules/platelet; mean +/- SEM, N=9) was similar to that bound to unstimulated control platelets (36,910 +/- 2,669) and did not differ significantly from the amount of antibody bound to ADP- treated platelets (P less than .01, N = 5). The amount of 10E5 bound to chymotrypsin-treated platelets correlated directly with the amount of fibrinogen bound to separate aliquots of the same platelet samples (r = .876, P less than .001). The 10E5 antibody caused virtually complete inhibition of both the binding of fibrinogen to chymotrypsin-treated platelets and the aggregation induced by exogenous fibrinogen. Immunoprecipitation studies of 125I-labeled chymotrypsin-treated platelets revealed that the 10E5 antibody bound proteins with molecular weights characteristic of glycoproteins IIb and IIIa. These data suggest that the fibrinogen receptor on chymotrypsin-treated platelets is identical to that on ADP-treated platelets and that this receptor is either near to, or on, the glycoprotein IIb/IIIa complex. 相似文献
52.
Results of percutaneous transluminal angioplasty 总被引:2,自引:0,他引:2
Percutaneous transluminal angioplasty (Dotter technique) was used in 2,942 cases of iliofemoral atheromatous disease. Results varied with the characteristics of the obstructing lesion (length and location) and the clinical stage of ischemia (claudication, rest pain, gangrene). Based on the foregoing, angioplasty is done either as the preferred primary treatment or for the relief of clinically advanced disease in patients unsuitable for high risk surgery. Success is favored by the use of aggregation inhibitors and single-use Teflon or balloon catheters; complications are few. 相似文献
53.
54.
Ultrasonic evaluation of the stomach, small bowel, and colon 总被引:4,自引:0,他引:4
55.
Ayse Humeyra Bicer Ayten Aylin Alsaffar 《Research in developmental disabilities》2013,34(11):3978-3987
The body mass index of 164 children (aged 4–18 years) attending four autism rehabilitation centers in Istanbul, Turkey, was determined and assessed using the BMI-for-age percentile charts by the World Health Organization (WHO). The mean intake of energy and nutrients of 115 children were calculated using three-day food records. The feeding assessment surveys filled in by the parents/caregivers indicated that the major feeding problem among children was food selectivity. The majority of the children were overweight or obese (58.5%). A total of 11% of children were found to be severely thin and thin. The calcium, zinc, vitamin B6 and folate intake of the majority of children were inadequate. The salt consumption in all age groups and cholesterol intake in normal, overweight and obese children were high. 相似文献
56.
57.
A dynamic probabilistic model based on hazard rate analysis, Monte Carlo modeling, and lead-time estimation techniques was developed to determine the optimal timing and frequency of chest radiography in the monitoring for relapse of children with treated Hodgkin disease. The analysis incorporates the performance characteristics of chest radiography, the natural history of the disease process, and therapeutic efficacy as a function of earliness of detection in the determination of optimal strategy. Examples of the model applied to the experiences of Stanford Medical Center and St. Jude Children's Research Hospital illustrate the utility of such a model in customizing an optimal monitoring strategy for a specific institution and clinical experience. The results suggest that monitoring protocols significantly overutilize chest radiography in the evaluation for recurrent Hodgkin disease in children. 相似文献
58.
Elastography of breast lesions: initial clinical results 总被引:24,自引:0,他引:24
Garra BS; Cespedes EI; Ophir J; Spratt SR; Zuurbier RA; Magnant CM; Pennanen MF 《Radiology》1997,202(1):79
59.
L-精氨酸对5/6肾大部切除大鼠残余肾代偿性增生的影响 总被引:4,自引:0,他引:4
目的观察1%L-精氨酸(L-arg)饮食对5/6肾大部切除大鼠(SNx)残余肾代偿性增生(CRG)的影响。方法实验分组:(1)假手术(sham)组;(2)sham+L-arg组;(3)SNx组;(4)SNx+L-arg组。大鼠于术后30天处死,观察L-arg对残余肾湿重(KW)、肾重/体重比(KW/BW)、CRG、残余肾蛋白质、DNA含量、细胞增生以及平均肾小球体积(VG)的影响。结果L-arg明显增加KW(P<0.05)、KW/BW(P<0.05)、CRG(P<0.05)以及残余肾蛋白质、DNA含量(P分别<0.01,0.001)。免疫组化显示,残余肾小管、间质增殖细胞核抗原(PCNA)阳性细胞数明显增加(P<0.05)。此外,SNx+L-arg组VG较SNx组增加16%。结论L-精氨酸可能刺激残余肾代偿性增生,此为限制L-精氨酸饮食治疗慢性肾衰提供了理论依据 相似文献
60.
Serap Simsek Yavuz Yesim Bicer Nihan Yapici Sibel Kalaca Osman Ozcan Aydin Gercek Camur Funda Kocak Zuhal Aykac 《Infection control and hospital epidemiology》2006,27(9):958-963
OBJECTIVE: To determine the incidence of and identify risk factors for sternal surgical site infection (SSI). DESIGN: Prospective cohort study. Data on potential risk factors, including the type of operating theater and infection data, were collected prospectively and analyzed by multivariate analysis. SETTING: Siyami Ersek Thoracic and Cardiovascular Surgery Hospital, a 700-bed teaching hospital and the largest center for cardiac surgery in Turkey. The cardiothoracic unit performs approximately 3,000 cardiac operations per year. PATIENTS: All adult patients who underwent cardiac surgery with sternotomy between January 14, 2002, and July 1, 2002, and who survived at least 4 days after surgery were included in the study. RESULTS: Potential risk factor data were complete for 991 patients. There was sternal SSI in 41 patients (4.1%). Female sex, diabetes mellitus, operation performed in the older operating theaters, and duration of procedure exceeding 5 hours were identified as independent risk factors for sternal SSI. CONCLUSIONS: Female and diabetic patients are at higher risk for sternal SSI and should be followed up carefully after cardiac surgery to prevent the development of sternal SSI. Reducing the duration of surgery could reduce the rate of postoperative sternal SSI. The operating theater environment may have an important role in the pathogenesis of sternal SSI, and appropriate ventilation of the operating theaters would be critical in the prevention of sternal SSI. 相似文献