全文获取类型
收费全文 | 313篇 |
免费 | 17篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 3篇 |
妇产科学 | 3篇 |
基础医学 | 45篇 |
口腔科学 | 7篇 |
临床医学 | 31篇 |
内科学 | 65篇 |
皮肤病学 | 22篇 |
神经病学 | 33篇 |
特种医学 | 3篇 |
外科学 | 24篇 |
综合类 | 2篇 |
预防医学 | 36篇 |
眼科学 | 10篇 |
药学 | 32篇 |
中国医学 | 3篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 7篇 |
2022年 | 7篇 |
2021年 | 9篇 |
2020年 | 8篇 |
2019年 | 12篇 |
2018年 | 11篇 |
2017年 | 6篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 9篇 |
2013年 | 15篇 |
2012年 | 37篇 |
2011年 | 35篇 |
2010年 | 18篇 |
2009年 | 13篇 |
2008年 | 20篇 |
2007年 | 17篇 |
2006年 | 16篇 |
2005年 | 16篇 |
2004年 | 19篇 |
2003年 | 11篇 |
2002年 | 10篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 4篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有331条查询结果,搜索用时 0 毫秒
51.
Teresa Casanovas Laia Jané Michael Herdman Alfonso Casado Beatriz Garcia Bibiana Prat Joan Fabregat 《Value in health》2010,13(4):455-462
ObjectiveTo assess the reliability and validity of a Spanish version of the LDQOL 1.0 (Liver Disease Quality of Life questionnaire).MethodsObservational, cross-sectional study in Spanish patients awaiting liver transplantation (LT). Feasibility was assessed by analyzing administration times and missing responses. Ceiling and floor effects were calculated and reliability was tested by examining internal consistency (Cronbach's alpha). Convergent validity was tested by examining correlations between LDQOL disease-specific and Short Form health survey with 36 questions (SF-36) dimensions. Known groups' validity was tested by examining the LDQOL's capacity to discriminate between groups defined by etiology and Child–Turcotte–Pugh (CTP) scores.ResultsA total of 200 patients were included for analysis. Mean age (SD) was 52.6 (9.8) years and 73% of the sample were male. The most common indication for LT was liver cancer (34%). Mean (SD) time to complete the questionnaire was 35.8 minutes (21.2 minutes). Missing responses were highest on the dimensions of sexual functioning and symptoms of liver disease. Ceiling effects were over 20% on 7 of the LDQOL's 12 disease-specific scales. Cronbach's alpha coefficients were over 0.70 on all but 2 dimensions. Correlations between SF-36 and LDQOL disease-specific dimensions generally fulfilled the hypotheses, with 35 of the 40 highest and lowest correlations (87.5%) being in the expected direction. The LDQOL discriminated well between patients in CTP class A and C, and as hypothesized, hepatocarcinoma and alcoholic cirrhosis patients scored better on most dimensions than patients with hepatitis C virus or other etiologies.ConclusionsThe Spanish version of the LDQOL 1.0 has shown satisfactory reliability and validity. 相似文献
52.
Mark F Harris Bibiana C Chan Christopher Daniel Qing Wan Nick Zwar Gawaine Powell Davies Team-link project team 《BMC health services research》2010,10(1):104
Background
This paper describes the development and implementation of an intervention to facilitate teamwork between general practice and outside allied and community health services and providers. 相似文献53.
54.
55.
Krempien RC Grehn C Haag C Straulino A Hensley FW Kotrikova B Hofele C Debus J Harms W 《Brachytherapy》2005,4(2):154-162
PURPOSE: Brachytherapy re-irradiation may offer an alternative re-treatment of recurrent head-and-neck cancer even after previous full dose radiation therapy. The purposes of this study were to determine the feasibility and accuracy of frameless image-guided interstitial needle implantation. METHODS AND MATERIALS: Between January 2000 and March 2003, 14 patients with biopsy-proven locally recurrent head-and-neck-cancer were retreated after previous full dose irradiation with combined external beam-brachytherapy with concomitant chemotherapy. Brachytherapy needle implantation was virtually planned taking into account the surrounding risk structures. Needles were implanted using an adapted frameless navigation system. Chemoradiotherapy was followed by 2-4 courses of chemotherapy every fourth week starting 4 weeks after the end of brachytherapy. RESULTS: The 1- and 2-year local control rates were 78% and 57%, respectively. Local control was obtained in 8/14 patients. The actuarial 1- and 2-year survival rates were 83% and 64%, respectively. The median survival was 28 months after a median follow-up of 21 months (range, 8-53). Six weeks after brachytherapy, 1 patient developed localized soft tissue necrosis which did not require surgical intervention. No additional grade III or IV late toxicity was seen after re-irradiation. Mean deviation of image-guided needle implantation was 3.4 mm for each needle (SD, 1.9 mm; range, 0.5-14 mm). The mean deviation of all needles of an implant was 4.3 mm (range, 2.3-8.6 mm). CONCLUSIONS: These data demonstrate that pulsed-dose-rate brachytherapy in combination with sequential chemotherapy is effective and safe in re-irradiation of locally recurrent oropharyngeal carcinomas and can be offered to patients with curative intent. Image guidance allows virtual planning and navigated implantation of brachytherapy needles with regard to optimized needle distribution and risk structures. 相似文献
56.
Grillo E Pérez-García B González-García C Vano-Galván S Jaén-Olasolo P 《Dermatology online journal》2012,18(6):8
Spiny keratoderma is an infrequent dermatosis consisting of multiple projections located on the palms and soles, with the distinct histopathology feature of a parakeratotic column above a hypogranular epidermis. This entity has been reported under several different names, such as punctate porokeratotic keratoderma, punctate keratoderma, palmar filiform hyperkeratosis, and spiny keratoderma of the palms and soles. Most of the cases described are acquired, although there are also familial cases. Since this disease has been under-diagnosed and under-reported, it is important for dermatologists to keep spiny keratoderma of the palms and soles in mind. We present a familial case of spiny keratoderma and review the literature. 相似文献
57.
58.
59.
60.