Author Keywords: Anorexia nervosa; growth hormone; somatomedin-C 相似文献
全文获取类型
收费全文 | 18468篇 |
免费 | 1032篇 |
国内免费 | 90篇 |
专业分类
耳鼻咽喉 | 320篇 |
儿科学 | 459篇 |
妇产科学 | 329篇 |
基础医学 | 2686篇 |
口腔科学 | 1564篇 |
临床医学 | 1359篇 |
内科学 | 3788篇 |
皮肤病学 | 453篇 |
神经病学 | 1314篇 |
特种医学 | 461篇 |
外科学 | 2157篇 |
综合类 | 76篇 |
一般理论 | 5篇 |
预防医学 | 2084篇 |
眼科学 | 255篇 |
药学 | 1320篇 |
中国医学 | 192篇 |
肿瘤学 | 768篇 |
出版年
2023年 | 196篇 |
2022年 | 417篇 |
2021年 | 743篇 |
2020年 | 468篇 |
2019年 | 604篇 |
2018年 | 745篇 |
2017年 | 521篇 |
2016年 | 557篇 |
2015年 | 641篇 |
2014年 | 828篇 |
2013年 | 1001篇 |
2012年 | 1444篇 |
2011年 | 1655篇 |
2010年 | 856篇 |
2009年 | 662篇 |
2008年 | 1106篇 |
2007年 | 1047篇 |
2006年 | 893篇 |
2005年 | 809篇 |
2004年 | 675篇 |
2003年 | 602篇 |
2002年 | 498篇 |
2001年 | 375篇 |
2000年 | 344篇 |
1999年 | 305篇 |
1998年 | 108篇 |
1997年 | 76篇 |
1996年 | 70篇 |
1995年 | 41篇 |
1994年 | 51篇 |
1993年 | 34篇 |
1992年 | 141篇 |
1991年 | 121篇 |
1990年 | 83篇 |
1989年 | 96篇 |
1988年 | 86篇 |
1987年 | 57篇 |
1986年 | 79篇 |
1985年 | 57篇 |
1984年 | 52篇 |
1983年 | 41篇 |
1982年 | 27篇 |
1981年 | 21篇 |
1980年 | 27篇 |
1979年 | 44篇 |
1978年 | 26篇 |
1977年 | 22篇 |
1976年 | 30篇 |
1971年 | 22篇 |
1969年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Franzotti EM Santos CV Rodrigues HM Mourão RH Andrade MR Antoniolli AR 《Journal of ethnopharmacology》2000,72(1-2):273-277
Sida cordifolia L. (Malvaceae) is used in folk medicine for the treatment of inflammation of the oral mucosa, blenorrhea, asthmatic bronchitis and nasal congestion. The anti-inflammatory, analgesic effects and acute toxicity of an aqueous extract of S. cordifolia were evaluated in animal models. The extract was prepared using leaves collected before the flowering period. The aqueous extract (AE) showed a significant inhibition of carrageenin-induced rat paw edema at a dose of 400 mg/kg administered orally, but did not block the edema induced by arachidonic acid. The AE also increased the latency period for mice in the hot plate test, and inhibited the number of writhes produced by acetic acid at the oral dose of 400 mg/kg. The aqueous extract of S. cordifolia showed low acute toxicity in mice. 相似文献
992.
993.
Santos VP 《Jornal de pediatria》1999,75(Z1):S103-S114
OBJECTIVES: To review the main diseases caused by the different strains of streptococcus, and to discuss the practical aspects of clinical diagnosis and the range of therapeutic treatments. METHODOLOGY: A review of the literature and a selection of the most meaningful themes for the pediatricians. RESULTS: The majority of the streptococcus described here are susceptible and have sensibility to penicillin. Different kinds of treatments aim at a better support to the offered scheme, including smaller amounts of doses per day, short-lived treatment and lowcost. CONCLUSION: Streptococcus infections are very frequently seen in the pediatrician's office. It is important to make an accurate diagnosis, and if possible a more simplified therapeutic treatment. 相似文献
994.
Feldman EJ Seiter K Traganos F Darzynkiewicz Z Goff H Pozzuoli M Baskind P Santos S Ahmed T 《Leukemia & lymphoma》2000,38(3-4):309-315
To evaluate a regimen including high-dose mitoxantrone in previously untreated adults with AML, 45 patients aged 21-59 (median 41) were given cytarabine, 3 g/m2 days 1-5, mitoxantrone, 80 mg/m2 day 2 and etoposide, 150 mg/m2 days 1,3,5. Post-remission therapy consisted of 5 cycles combining the same agents at reduced doses. Complete remission was seen in 36 patients. The observed 3-year survival is 28%. Cytogenetic pattern and CD34 expression correlated with response and survival. Significant toxicity included myelosuppression, mucositis, diarrhea and hyperbilirubinemia. Ventricular ejection fraction was generally reduced, with clinical cardiac dysfunction in only 2 patients. This high-dose mitoxantrone combination can be administered to young adults with AML with tolerable toxicity and results comparable to those of other dose-intensive regimens. 相似文献
995.
Birgit Alsbjerg Thor Haahr Helle O Elbaek Rita Laursen Betina B Povlsen Peter Humaidan 《Reproductive biomedicine online》2019,38(5):677-682
Research question
What are the reproductive outcomes of Bologna criteria poor responders undergoing dual stimulation (DuoStim) and subsequent cryopreserved embryo transfer?Design
Case series of patients treated during the period August 2015 to March 2018 in a public fertility clinic. The study included 54 Bologna criteria poor responder IVF patients younger than 42 years receiving a follicular stimulation (DuoStim 1) followed by a luteal phase stimulation (DuoStim 2) within the same cycle, both stimulations being performed with corifollitropin alfa followed by a subsequent cryopreserved embryo transfer cycle. The primary endpoint was the number of oocytes retrieved in DuoStim 1 compared with DuoStim 2. The secondary endpoint was ongoing pregnancy rate (OPR) at 12 weeks of gestation.Results
The mean number of oocytes retrieved in DuoStim 1 and DuoStim 2 was 2.4 ± 2.1 versus 3.7 ± 2.6, respectively; thus, a total of 1.2 (95% CI, 0.46–1.96) more oocytes was retrieved in DuoStim 2 compared with DuoStim 1 (P = 0.002). The OPR at 12 weeks was 20% (11/54) in this poor ovarian response population with a mean age of 36.7 years.Conclusions
Luteal phase stimulation results in more oocytes in poor responders compared with follicular phase stimulation. DuoStim, using corifollitropin alfa followed by individualized FSH dosing, appears to be an alternative to conventional follicular phase stimulation, decreasing the risk of cycle cancellation. 相似文献996.
Objectives
To describe the association between sleep duration and weight–height development in children and adolescents.Source of data
A non-systematic search in the MEDLINE database was performed using the terms anthropometry, body composition, overweight, obesity, body mass index, growth, length, short stature, sleep, children, and infants and adolescents, limited to the last 5 years. The references cited in the revised articles were also reviewed, when relevant.Synthesis of data
Sleep disorders are prevalent in the pediatric population. Among them, insomnia, which leads to a reduction in total sleep time, is the most prevalent disorder. Evidence found in the current literature allows the conclusion that sleep time reduction has a role in the current pandemic of overweight and obesity. Studies associating sleep deprivation and deficit in height growth are still insufficient.Conclusions
The association between shorter sleep duration and risk of overweight and obesity is well established for all pediatric age groups. However, more evidence is needed to establish an association between insufficient sleep duration and height growth deficit. Pediatricians should include the encouragement of healthy sleep habits in their routine guidelines as an adjuvant in the prevention and management of excess weight. 相似文献997.
Francisco Rosa Peter J.F.M. Lohuis João Almeida Mariline Santos Jorge Oliveira Cecília Almeida e Sousa Miguel Ferreira 《Revista brasileira de otorrinolaringologia (English ed.)》2019,85(2):170-175
Introduction
The evaluation of surgical outcomes measured by patient satisfaction or quality of life is very important, especially in plastic surgery. There is increasing interest in self-reporting outcomes evaluation in plastic surgery.Objective
The aim of this study was to perform the translation, cross-cultural adaptation and validation of “The Utrecht questionnaire for outcome assessment in aesthetic rhinoplasty” from English to Portuguese.Methods
Retrospective study involving 50 patients undergoing to rhinoplasty comparing the preoperative period with the current postoperative situation (minimum 6 months and maximum 24 months postoperatively). Statistical analysis was performed to assess internal consistency, test–retest reliability, validity and responsiveness.Results
No patients received a negative score on the visual analogue scale comparing preoperative and postoperative appearance. The postoperative improvement on the visual analogue scale revealed a Gaussian curve of normal distribution with a mean improvement of 4.44 points. The test–retest reliability showed a positive correlation between the postoperative response and the same questionnaire repeated ninety-six hours later. The internal consistency was high (Cronbach's alpha value: Preoperative = 0.88; Postoperative = 0.86). The authors observed a significant improvement in response for all individual questions in the postoperative phase as compared with preoperative situation (t-student test – p < 0.05).Conclusion
The Portuguese version of “The Utrecht questionnaire for outcome assessment in aesthetic rhinoplasty” is a valid instrument to assess patients’ outcomes following rhinoplasty surgery. 相似文献998.
Maria Teresa Botti Rodrigues dos Santos DDSc PhD Danilo Masiero MD Maria Regina Lorenzetti Simionato DDSc PhD 《Special care in dentistry》2002,22(3):103-107
This study was conducted to examine the oral condition and the salivary and microbiological parameters associated with dental caries in 62 children with cerebral palsy, who came from households of low socioeconomic status (Study Group). This group had mixed (6 to 11 years old) and permanent (11 to 16 years old) dentition. Dental examinations were performed to measure dental caries, plaque index, salivary levels of mutans streptococci and lactobacilli, salivary flow rate, pH of stimulated saliva, and buffer capacity of saliva. A group of 67 non-handicapped children from similar socioeconomic backgrounds also were examined using these parameters (Control Group). Data were analyzed statistically by non-parametric tests and by correlation. The results showed that children with cerebral palsy who had permanent dentitions had a higher mean decayed, missing and filled surfaces index, as well as a higher plaque index for both sexes. Microbiological examination revealed higher levels of mutans streptococci among Study Group subjects with mixed dentition than in the Control Group. Also, lactobacillus counts were higher in the Study Group, regardless of sex or dentition. With respect to salivary flow rate, pH and buffering capacity, lower mean values were obtained for the Study Group. 相似文献
999.
M N Dulhoste P Dos Santos G Cauchi A Lemouroux I Cheradame J Clémenty 《Archives des maladies du coeur et des vaisseaux》1992,85(8):1119-1122
The aim is the analysis of the P wave on the signal averaged ECG in 31 pts: 12 control pts (6 M, 6 W, 40 +/- 10 y) 12 HTA (9 M, 3 W, 60 +/- 7 y), 7 pts (5 M, 2W, 48 +/- 7 y) with sustained paroxystic atrial fibrillation (AF) without organic heart disease, without antiarrhythmic drugs. We measured the filtered P wave duration (Ad), the integral of Ad, the root mean square voltage of Ad for the last 10, 20, 30, 40, 60 msec and the duration of P wave on the ECG in lead II (P II) and the echocardiographic dimensions of the atria (LAd). HTA Ad (132 +/- 12 msec)* et > control Ad (116 +/- 10 msec) HTA LAd (38 +/- 3 mm) et > control LAd (31 +/- 0.7 mm) HTA PII (120 +/- 1.5 mm)* et > control PII (88 +/- 10 mm). The difference between HTA Ad (132 +/- 12 msec) and AF Ad (129 +/- 7 msec) is not significant. The linear regression tests don't show correlation between P II and Ad and between LAd and Ad in HTA group. There is a correlation between Ad and LAF in AF group (r = 0.83, p 0.02). HTA RMS 2o (2.2 + 0.6 microV), control RMS 2o (3.9 + 1.8 V) but HTA RMS 2o and AF RMS 2o (2.4 +/- 0.6 microV) are not significantly different and are not correlated with LAd and PII. A long duration of P filtered P wave and a low RMS 2o observed in HTA group and AF group would be a criteria of atrial vulnerability. p < 0.05. 相似文献
1000.
Jose A. Cabranes Isabel Almoguera Jose L. Santos Isabel Hidalgo Maria M. Borque Jesus Del Olmo 《Progress in neuro-psychopharmacology & biological psychiatry》1988,12(6):865-871
1. 1. Plasma concentrations of somatomedin-C and GH were determined in 21 patients diagnosed as anorexia nervosa (AN) and in 44 controls.
2. 2. Somatomedin-C concentrations were significantly lower in pubertal AN patients than in controls, but not in post pubertal patients.
3. 3. GH was increased in both pubertal and post pubertal AN patients, although more in pubertal AN patients.
4. 4. Our results suggest that the hormonal alterations that appear in AN constitute a mechanism of defense against starvation. The activation of these defense mechanisms and the degree of modification produced in normal hormonal patterns depend not only on caloric intake but also on metabolic requirements.