鼻内窥镜下筛窦切除术治疗视神经炎4例报告

目的：评价鼻内窥镜下筛窦切除术治疗视神经炎的疗效。方法：对４例视神经炎患者行鼻内窥镜下筛窦切除术。结果：显效２例,有效２例。鼻塞,眼胀,头痛症状缓解。结论：对合并有筛窦炎的视神经炎患者,在保守治疗无效或治疗后有反复时,及时行鼻内窥镜下筛窦切除术有效率高,且安全、可靠。     

无创性动态阴茎海绵体测压诊断阴茎勃起功能障碍

目的　探讨应用无创性动态阴茎海绵体测压 (VISER)在勃起功能障碍 (ED)诊断中的价值。　方法　对 5 3例ED患者的PGE1阴茎海绵体内注射试验、VISER及彩色双功能超声检查结果进行对比分析。　结果　PorstⅢ级者 4 3例 ,平均海绵体压力和压力指数分别为 14 4 .2 9mmHg(1mmHg=0 .133kPa)和 1.2 4。 4 2例血管功能正常 ,1例为静脉性ED ;PorstⅡ级者 10例 ,平均海绵体压力和压力指数为 87.76mmHg和 0 .81,两组间比较差别有显著性意义 (P <0 .0 5 ) ;PorstⅡ级者中动脉性ED2例 ,静脉性ED8例 ,两组间海绵体压力比较差别有显著性意义 (P <0 .0 5 )。　结论　VIS ER是一种有效的无创性诊断ED的方法 ,对动脉性及静脉性ED的鉴别亦有一定价值。     

Effects of nerve growth factor on brain glutathione-related enzymes from aged rats

Summary— Neurotrophins, like the nerve growth factor (NGF), trigger a variety of biological effects in their targets. Stimulating effects on antioxidant defenses have been postulated to underlie neurotrophic influence on neuron survival and maintenance. To test whether NGF is capable of inducing changes in glutathione-related enzymes in the aged cognitively impaired brain, glutathione reductase (GRD), glutathione S-transferase (GST) and total glutathione peroxidase (GPX) activities were measured in the striatum, septum, hippocampus and frontal cortex of four Sprague-Dawley rat groups: young (2 months old), aged (20 months old) untreated, aged cytochrome c-treated, and aged NGF-treated (icv delivery, 34 4mUg during 28 days). All the aged rats utilized in the study were memory impaired according to their performance in the Morris water maze test. These aged rats showed increases in the activities of septal and hippocampal GST, as well as, in the hippocampal, striatal and cortical GPX. These increases could be interpreted as compensatory responses to cope with the oxidative damage that has been accumulated by the aged brain. The increases in hippocampal and cortical GPX activity were attenuated by NGF treatment, whereas the neurotrophin induced an increase in GRD activity in the striatum of aged rats. These results point out GRD and GPX as possible targets of the neurotrophic effects.     

药用矿物蒙脱石的X-射线定向衍射分析

目的：揭示蒙脱石层状晶体结构及层间吸附和膨胀性能，为其作为药物和药剂辅料提供科学依据。方法：将样品提纯，获得粒径小于1μm的胶体，制成取向样品，进行X－射线定向衍射分析。结果：得到了有关蒙脱石层间域在不同条件下的变化规律。结论：蒙脱石的层间吸附是可能的，而且定向衍射方法可以定量测定其层间距离。     

Lifelong treatment with gammaglobulin for primary antibody deficiencies: the patients' experiences of subcutaneous self-infusions and home therapy

Primary antibody deficiencies are chronic conditions and the patients usually need lifelong replacement therapy with gammaglobulin to prevent or reduce infections It has been shown that the gammaglobulm can be given safely as subcutaneous infusions, instead of intramuscular injections or intravenous infusions The major aim of this multi-centre study was to investigate the perceptions of the subcutaneous method among patients using it, both in hospital settings and as self-infusions at home The study included 152 patients 89 women, 63 men, mean age 44 years (range 18-76) Data were collected by using questionnaires The patients were found to have a strongly positive attitude towards receiving the replacement therapy as subcutaneous infusions, perceived the method as effective in preventing infections and wished to retain the treatment However, the younger patients found the subcutaneous infusions more uncomfortable and were less determined to continue with the therapy as compared with the older individuals The responsibility for self-infusions at home was accepted by the patients, leading to an increased independence from the health care personnel and to a feeling of flexibility and freedom As these patients have a chronic disease and are in need of lifelong treatment, it is important to discuss the development of structured education and training programmes in which special emphasis is placed on the support of the younger patients It is suggested that Orem's nursing model of self-care may serve as a conceptual framework for nurses working in this specific area of nursing care