全文获取类型
收费全文 | 6716篇 |
免费 | 400篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 141篇 |
儿科学 | 204篇 |
妇产科学 | 67篇 |
基础医学 | 817篇 |
口腔科学 | 80篇 |
临床医学 | 623篇 |
内科学 | 1869篇 |
皮肤病学 | 91篇 |
神经病学 | 581篇 |
特种医学 | 228篇 |
外国民族医学 | 7篇 |
外科学 | 1130篇 |
综合类 | 36篇 |
预防医学 | 358篇 |
眼科学 | 63篇 |
药学 | 412篇 |
中国医学 | 6篇 |
肿瘤学 | 443篇 |
出版年
2023年 | 36篇 |
2022年 | 55篇 |
2021年 | 132篇 |
2020年 | 74篇 |
2019年 | 135篇 |
2018年 | 175篇 |
2017年 | 119篇 |
2016年 | 136篇 |
2015年 | 172篇 |
2014年 | 217篇 |
2013年 | 279篇 |
2012年 | 438篇 |
2011年 | 434篇 |
2010年 | 229篇 |
2009年 | 232篇 |
2008年 | 367篇 |
2007年 | 367篇 |
2006年 | 423篇 |
2005年 | 384篇 |
2004年 | 327篇 |
2003年 | 342篇 |
2002年 | 304篇 |
2001年 | 130篇 |
2000年 | 137篇 |
1999年 | 122篇 |
1998年 | 76篇 |
1997年 | 52篇 |
1996年 | 60篇 |
1995年 | 40篇 |
1994年 | 39篇 |
1993年 | 35篇 |
1992年 | 97篇 |
1991年 | 86篇 |
1990年 | 64篇 |
1989年 | 72篇 |
1988年 | 54篇 |
1987年 | 83篇 |
1986年 | 62篇 |
1985年 | 69篇 |
1984年 | 43篇 |
1983年 | 43篇 |
1982年 | 24篇 |
1981年 | 22篇 |
1979年 | 45篇 |
1977年 | 21篇 |
1976年 | 25篇 |
1974年 | 28篇 |
1973年 | 28篇 |
1972年 | 21篇 |
1971年 | 34篇 |
排序方式: 共有7156条查询结果,搜索用时 15 毫秒
221.
Aurélien Fotso Fotso Frida Longo Paul Désiré Dzeufiet Djomeni Siméon Fogue Kouam Michael Spiteller Alain Bertrand Dongmo J. P. Savineau 《Inflammopharmacology》2014,22(2):105-114
Bidens pilosa is an Asteraceae widely used in traditional medicine for the treatment of various ailments including pain and inflammation. The present work was undertaken to assess the analgesic and antiinflammatory properties of the ethyl acetate fraction of methylene chloride/methanol (1:1) extract of leaves of Bidens pilosa at the gradual doses of 50, 100 and 200 mg/kg in mice and rats, respectively. The analgesic properties of Bidens pilosa were investigated using the acetic acid writhing, hot plate, capsaicin and formalin-induced pain models. This was followed by a study of the antiinflammatory properties using carrageenan, dextran, histamine and serotonin to induce acute inflammation in rat hind paw. The extract provided a significant (p < 0.01) reduction in pain induced by all four models of nociception. It also presented significant (p < 0.05) antiinflammatory activity in all four models of acute inflammation. These results show that the ethyl acetate fraction of methylene chloride/methanol (1:1) of Bidens pilosa has both analgesic and antiinflammatory properties. The qualitative analysis of the fraction by the high-performance liquid chromatography (HPLC) fingerprint revealed the presence of two flavonoids, namely quercetin and iso-okanin, known to have antiinflammatory and antinociceptive properties, which could be responsible for the analgesic and antiinflammatory effects observed. 相似文献
222.
Sarra Smati MD Blandine Tramunt MD Matthieu Wargny MD Cyrielle Caussy MD Bénédicte Gaborit MD Camille Vatier MD Bruno Vergès MD Deborah Ancelle MD Coralie Amadou MD Leila A. Bachir MD Olivier Bourron MD Christine Coffin-Boutreux MD Sara Barraud MD Anne Dorange MD Bénédicte Fremy MD Jean-François Gautier MD Natacha Germain MD Etienne Larger MD Stéphanie Laugier-Robiolle MD Laurent Meyer MD Arnaud Monier MD Isabelle Moura MD Louis Potier MD Nadia Sabbah MD Dominique Seret-Bégué MD Patrice Winiszewski MD Matthieu Pichelin PharmD Pierre-Jean Saulnier MD Samy Hadjadj MD Bertrand Cariou MD Pierre Gourdy MD for the CORONADO investigators 《Diabetes, obesity & metabolism》2021,23(2):391-403
223.
224.
Jacques Monteil Valerie Le Brun-Ly Florent Cachin Xavier Zasadny Jean-François Seitz Olivier Mundler Marie Selvy Denis Smith Eric Rullier Sandrine Lavau-Denes Guillaume Lades Anais Labrunie Cedric Lecaille Nathalie Valli Sophie Leobon Eric Terrebonne Elise Deluche Nicole Tubiana-Mathieu 《Digestive and liver disease》2021,53(2):231-237
BackgroundA surveillance program was performed in colorectal cancer (CRC) patients after surgery, to diagnose asymptomatic recurrence.AimsTo assess whether 18-FDG positron emission tomography/CT (PET/CT) improved the detection of recurrence during a 3-year follow-up.MethodsA multicentre, two-arm randomised prospective trial comparing different 36-month follow-up strategies. Complete colonoscopy was performed at baseline and after 3 years and clinical exams with imaging every 3 months. The conventional arm (A) received carcinoembryonic antigen, liver echography, and alternated between lung radiography and computed tomography (CT) scans. The experimental arm (B) received PET/CT.ResultsA total of 365 patients with colon (79.4%) or rectal cancer (20.6%), stages II (48.2%) or III (50.8%), were enroled in this study. At 36 months, intention-to-treat analysis revealed recurrence in 31 (17.2%) patients in arm A and 47 (25.4%) in arm B (p = 0.063). At 3 years, 7 of 31 relapses (22.5%) in arm A were surgically treated with curative intent, compared to 17 of 47 (36.2%) in arm B (p = 0.25). The rates of recurrence and new cancers were higher in arm B than arm A (p = 0.038).ConclusionsPET/CT follow-up every 6 months did not increase the rate of recurrence at 3 years or the rate of surgically treated recurrence compared with conventional follow-up. 相似文献
225.
Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors 总被引:7,自引:0,他引:7
The effects of monocytic/macrophage and granulocytic differentiation induced by phorbol myristate acetate (TPA) and all-trans retinoic acid, respectively, were tested on the induction of apoptosis in human promyelocytic leukemia HL-60 cells treated with topoisomerase I and II inhibitors. Using a filter-binding assay, we observed a strong inhibition of DNA fragmentation induced by 3- and 24-hour continuous exposure to camptothecin, VP-16, VM-26, and m-AMSA in TPA- differentiated cells. The inhibition of the typical internucleosomal DNA fragmentation was confirmed by agarose gel electrophoresis. By contrast, drug-induced DNA fragmentation was not inhibited in retinoic acid-differentiated cells, and apoptosis occurred in these cells after 4 to 5 days in the absence of drug treatment. The TPA inhibitory effect was maximal after 24 hours of treatment and was correlated with differentiation, because phorbol dibutyrate ester was active, whereas 4- alpha-TPA, a nontumor promoter that does not induce differentiation, was not active. Using alkaline elution, we observed that TPA and retinoic acid differentiation were associated with changes in topoisomerase-mediated DNA breaks that were not correlated with their differential effects on drug-induced DNA fragmentation. Moreover, TPA also inhibited DNA fragmentation induced by vinblastine, cycloheximide, calphostin C, and x-rays. Using a cell-free system, we observed that DNA fragmentation was not inhibited in nuclei from TPA-differentiated cells. Rather, inhibition of apoptosis seemed to take place in the cytoplasm. We conclude that phenotypic changes associated with TPA- induced differentiation include inactivation of a cytoplasmic activity that can induce DNA fragmentation associated with apoptosis. 相似文献
226.
227.
228.
Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study 下载免费PDF全文
Guillaume de Bonnecaze MD MSc Benjamin Verillaud MD PhD Leonor Chaltiel PhD Sylvestre Fierens MD Mark Chapelier MD Cécile Rumeau MD MSc Olivier Malard MD PhD Marie Gavid MD MSC Xavier Dufour MD PhD Christian Righini MD PhD Emmanuelle Uro‐coste MD PhD Michel Rives MD Christine Bach MD Bertrand Baujat MD PhD François Janot MD PhD Ludovic de Gabory MD PhD Sebastien Vergez MD PhD 《International forum of allergy & rhinology》2018,8(9):1065-1072
Background
Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management.Methods
A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors.Results
Definitive analyses focused on 54 patients with a majority of advanced stage; the 3‐year overall survival (OS) and 3‐year recurrence‐free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow‐up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph‐node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy (p = 0.02) and intensity‐modulated radiotherapy (p = 0.007). In the multivariate analyses, only induction chemotherapy (p = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS.Conclusion
Multimodal therapies including induction chemotherapy and intensity‐modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required.229.
230.
G Bertrand P Charlier T Touche E Hazan R Gourgon 《Archives des maladies du coeur et des vaisseaux》1984,77(3):349-355
The case of a 20 year old woman followed up since adolescence for a progressive congestive cardiomyopathy with mitral regurgitation is reported. She was reinvestigated after hospital admission for cardiac decompensation and supraventricular arrhythmias; 2D echocardiography showed signs of severe mitral regurgitation with thickened mitral leaflets prolapsing into a dilated left atrium and, above all, abnormal diastolic wall motion related to restriction of left ventricular filling with no apparent systolic dysfunction : pulsed Doppler studies confirmed the diagnosis of mitral regurgitation but also showed retrograde diastolic flow in the aortic arch (without aortic regurgitation) and in the main pulmonary artery. Angiography showed these disturbances to be due to an abnormal origin of the left coronary artery in the main pulmonary artery. Reimplantation of the left coronary in the aorta and mitral annuloplasty were justified by the poor spontaneous prognosis of this congenital abnormality which has rarely been described in adults. 相似文献