全文获取类型
收费全文 | 29263篇 |
免费 | 2225篇 |
国内免费 | 87篇 |
专业分类
耳鼻咽喉 | 386篇 |
儿科学 | 840篇 |
妇产科学 | 561篇 |
基础医学 | 3774篇 |
口腔科学 | 379篇 |
临床医学 | 2910篇 |
内科学 | 6394篇 |
皮肤病学 | 424篇 |
神经病学 | 2757篇 |
特种医学 | 1198篇 |
外科学 | 4988篇 |
综合类 | 308篇 |
现状与发展 | 1篇 |
一般理论 | 51篇 |
预防医学 | 2279篇 |
眼科学 | 434篇 |
药学 | 1479篇 |
中国医学 | 45篇 |
肿瘤学 | 2367篇 |
出版年
2023年 | 323篇 |
2022年 | 560篇 |
2021年 | 1293篇 |
2020年 | 707篇 |
2019年 | 1020篇 |
2018年 | 1231篇 |
2017年 | 857篇 |
2016年 | 831篇 |
2015年 | 1005篇 |
2014年 | 1361篇 |
2013年 | 1654篇 |
2012年 | 2425篇 |
2011年 | 2381篇 |
2010年 | 1291篇 |
2009年 | 1024篇 |
2008年 | 1579篇 |
2007年 | 1654篇 |
2006年 | 1464篇 |
2005年 | 1331篇 |
2004年 | 1147篇 |
2003年 | 975篇 |
2002年 | 835篇 |
2001年 | 239篇 |
2000年 | 228篇 |
1999年 | 228篇 |
1998年 | 171篇 |
1997年 | 153篇 |
1996年 | 157篇 |
1995年 | 134篇 |
1994年 | 119篇 |
1993年 | 108篇 |
1992年 | 157篇 |
1991年 | 177篇 |
1990年 | 155篇 |
1989年 | 177篇 |
1988年 | 142篇 |
1987年 | 148篇 |
1986年 | 127篇 |
1985年 | 123篇 |
1984年 | 133篇 |
1983年 | 117篇 |
1982年 | 105篇 |
1981年 | 99篇 |
1980年 | 77篇 |
1979年 | 117篇 |
1978年 | 119篇 |
1977年 | 72篇 |
1976年 | 67篇 |
1973年 | 65篇 |
1972年 | 58篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
The displaced femoral neck fracture. Internal fixation versus bipolar endoprosthesis. Results of a prospective, randomized comparison 总被引:3,自引:0,他引:3
T J Bray E Smith-Hoefer A Hooper L Timmerman 《Clinical orthopaedics and related research》1988,(230):127-140
The displaced femoral neck fracture poses difficult decision-making issues for the orthopedic surgeon. Young patients frequently require a rapid open reduction and rigid internal fixation in the face of multiple associated injuries. Elderly patients present the typical decision dilemma of internal fixation versus arthroplasty. Consecutive, randomized, prospective series of cases for evaluation of alternatives in the treatment of this difficult fracture are lacking. Between 1982 and 1984, 34 elderly patients with displaced femoral neck fractures were randomized to open reduction or hemiarthroplasty study groups. Although the surgical risks are relatively high, two-year observations showed better functional results in the cemented hemiarthroplasty group. 相似文献
32.
Arthroscopic shoulder surgery has become a safe tool for evaluation and treatment of a wide range of shoulder problems with few complications. With ever-improving technology (and commitment to motor skill development among arthroscopists), we can expect to maintain this low rate despite increasing procedure complexity. Avoiding complications in arthroscopic shoulder surgery requires careful preoperative planning, judicious patient selection, a thorough understanding of arthroscopic anatomy, and facility with arthroscopic techniques. 相似文献
33.
Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials.
Vincent Meininger Gilbert Bensimon Walter R Bradley Benjamin Brooks Patrice Douillet Andrew A Eisen Lucette Lacomblez P Nigel Leigh Wim Robberecht 《Amyotrophic lateral sclerosis and other motor neuron disorders》2004,5(2):107-117
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal motor neuron disease. We carried out two randomized, double-blind, placebo-controlled, multi-centre, multi-national studies with xaliproden (a drug with neurotrophic effect) to assess drug efficacy and safety at two doses. Patients with clinically probable or definite ALS of more than 6 months and less than 5 years duration were randomly assigned to placebo, 1 mg or 2 mg xaliproden orally once daily as monotherapy in Study 1 (n=867); or to the same regimen with addition of riluzole 50 mg bid background therapy in Study 2 (n=1210 patients). The two primary endpoints were defined as: 1. Time to death, tracheostomy, or permanent assisted ventilation (DTP), and 2. Time to vital capacity (VC)<50% or DTP before (log-rank test) and after adjustment using a Cox proportional hazard model for prespecified prognostic factors. Secondary endpoints were rates of change of various functional measures. In Study 1, primary outcome measures did not reach statistical significance. For the 2 mg group, for time to VC<50% analysis (without DTP) a significant 30% RRR was obtained (95% confidence interval [CI]: 8.46, P=0.009). In Study 2, no significant results were obtained. However, there was a trend in favour of add-on 1 mg dose xaliproden vs. placebo (RRR 15% [-6.31, ns] for time to VC<50%; RRR 12% [CI: -6.27, ns] for time to VC<50% or DTP). Adjusted RR ratios were consistently more favourable for the xaliproden groups. Tolerability was good, and dose-dependent side effects were largely associated with the serotonergic properties of xaliproden. An effect of xaliproden on functional parameters, especially VC, was noted. Although this effect did not reach statistical significance, xaliproden had a small effect on clinically noteworthy aspects of disease progression in ALS. 相似文献
34.
L S Benjamin 《Dental clinics of North America》1992,36(1):77-93; discussion 94-5
The subperiosteal implant has long been regarded as the most successful, predictable, and versatile of all implant systems. In some cases, however, anatomic morphology and surgical technique present certain limitations for the subperiosteal procedure. Through CAD/CAM multiplanar diagnostic imaging, not only have we been able to eliminate the first stage of the surgical procedure, but we have expanded the capabilities and versatility of the subperiosteal procedure. In addition, coating the subperiosteal implant frame with hydroxyapatite has allowed the achievement of bony union, thus increasing the long-range prognosis of the individual case. 相似文献
35.
Exenatide. 总被引:1,自引:0,他引:1
Grant M Bray 《American journal of health-system pharmacy》2006,63(5):411-418
PURPOSE: The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, and dosage and administration of exenatide are discussed. SUMMARY: Exenatide, derived from a compound found in the saliva of the Gila monster, is an incretin mimetic agent that enhances glucose-dependent insulin secretion and has several other antihyperglycemic actions. The drug is indicated as adjunctive therapy to improve glycemic control in patients with type 2 diabetes mellitus who are taking metformin, a sulfonylurea, or both but who have not achieved adequate glycemic control. Peak plasma concentration following subcutaneous administration of exenatide is attained in 2.1 hours. The mean apparent volume of distribution after administration of a single subcutaneous dose is 28.3 L. The terminal half-life of the drug is 2.4 hours. Based on animal studies, the bioavailability of exenatide after subcutaneous injection has been estimated to be between 65% and 75%. The drug is predominantly eliminated by glomerular filtration followed by proteolytic degradation. Clinical trials have shown that exenatide given subcutaneously twice daily significantly reduced glycosylated hemoglobin values when maximum doses of a sulfonylurea, metformin, or both were ineffective. The most common adverse effects are nausea, vomiting, diarrhea, jitteriness, dizziness, headache, and dyspepsia. Drug-drug interactions with digoxin, lovastatin, lisinopril, and acetaminophen have been documented. The recommended starting dosage is 5 microg subcutaneously twice daily within one hour before the morning and evening meals. CONCLUSION: Exenatide offers a novel treatment option for patients with type 2 diabetes mellitus who are refractory to metformin or sulfonylurea therapy or both. 相似文献
36.
37.
D E Fleischer F al-Kawas S Benjamin J H Lewis J Kidwell 《Gastrointestinal endoscopy》1992,38(4):411-414
In 1989, the American Society for Gastrointestinal Endoscopy released a quality assurance monograph in which a procedure review process was outlined. The major elements of the program for quality assurance in gastrointestinal endoscopy included: (1) procedure reports, (2) an endoscopic unit record, and (3) a procedure review. This study was designed to use the procedure review process to determine the incidence of complications, to identify quality assurance issues, and to determine whether audits and/or studies would result from this process. To make a meaningful interpretation as to what constitutes an important complication, a classification to define potential problems was established. Using this classification, a complication was identified in 64 of 3287 procedures (1.9%). These complications were discussed in a monthly morbidity and mortality conference. Additionally, 21 quality assurance issues were identified that led to four studies addressing these quality assurance issues. 相似文献
38.
Benjamin Volovitz Jacob Amir Hagit Malik Maya Lerman Itzhak Varsano 《The Journal of asthma》1994,31(1):27-34
Administration of theophylline to asthmatic children is frequently associated with an adverse influence on their behavior. The efficacy and behavioral effects of the administration of high-dose theophylline (T) and ketotifen (K) in various combinations were evaluated prospectively in a double-blind, placebo controlled study in 55 children with moderately severe perennial asthma. During a baseline period of 2 weeks, theophylline (serum level of 10-20 μg/ml) was administered to all the children. After this period the patients were randomly allocated into four comparable groups. The children were treated during a 12-week period with: T + K-Placebo (T group); T + K (T + K group); half-dose T + K (T/ 2 + K group); or placebo of both T and K (P group). During the 12-week treatment period, as compared to the baseline period, only the three groups of children who received active therapy (T + P, T + K, T/2 + K) showed a similar reduction in the number of days with asthmatic symptomatology, improvement of the total asthmatic symptoms score, and increased PEFR. The behavioral activity of the children (assessed by the Conner's rating scale) improved significantly only in the groups receiving placebo or T/2 + K. The results of this study suggest that a combination therapy of half the recommended therapeutic dose of theophylline with ketotifen can be clinically as effective as therapy with a full dose of theophylline, but with significantly less adverse behavioral effects. 相似文献
39.
Michael J Huerkamp Kimberly A Benjamin Sonji K Webb Jennifer K Pullium 《Contemporary topics in laboratory animal science》2004,43(2):35-36
The pinworm Syphacia muris was eradicated from rats after treatment with fenbendazole-medicated chow (150 ppm) and without environmental decontamination for > 54 months. However, this regimen was successful only when the treatment was delivered and efficacy monitoring was done by personnel of the institutional animal resources program. The same pinworm elimination program failed 7 to 24 months after the cessation of treatment in a satellite colony in which animal care, including provision of medicated diet and sample collection for efficacy monitoring, was provided by research personnel. A failure to uniformly deliver adequate therapeutic doses or reinoculation of rats with pinworm eggs from the contaminated environment could not be excluded as causes of the failure. However, there were risk factors, and animal care practices unique to the satellite colony that may have facilitated the re-emergence of pinworms. These risk factors included hand-washing of cages, storage of contact bedding in areas that were not vermin-proof, and animal care provided by personnel having contact with rodents of pet-store origin. 相似文献
40.
The Multiphasic Environmental Assessment Procedure (MEAP; Moos and Lemke, 1984) was used to assess three long-stay settings within a geriatric hospital, one of which is a non-nursing unit committed to the philosophy of residents viewing the setting as their own home. Findings suggest positive outcomes for residents on the nonnursing unit, and support the view that types of care fostering independence and personal responsibility of elderly residents in their setting may be associated with increased mental functioning and activity. The lack of trained nursing staff had no detrimental effect on any measure of resident life, and some specific caring practices on the unit may be interpreted as having a positive outcome for residents. 相似文献