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排序方式: 共有1374条查询结果,搜索用时 78 毫秒
991.
Current treatment options for endometrial cancer 总被引:7,自引:0,他引:7
Santin AD Bellone S O'Brien TJ Pecorelli S Cannon MJ Roman JJ 《Expert review of anticancer therapy》2004,4(4):679-689
In North America, endometrial cancer is the most prevalent cancer of the female genital tract. On the basis of clinical and histologic variables, two main types of endometrial cancer have been described: Type I tumors, which are usually well differentiated and endometrioid in histology and account for the majority of cases; and Type II, which are poorly differentiated tumors, often with serous papillary or clear cell histology. Due to the early declaration of the disease by vaginal bleeding, approximately 80% of endometrial cancers are diagnosed at an early stage. Total abdominal hysterectomy and bilateral salpingo-oophorectomy with or without lymph node dissection remains the cornerstone of treatment. Tumor stage, histologic grade and depth of myometrial invasion are the most important prognostic factors. If myometrial invasion to 50% or more of the myometrial width and/or grade 2 or 3 histology is present, pelvic radiotherapy is indicated to reduce the risk of pelvic recurrence. Postoperative radiation therapy may improve local control but does not affect survival for Stage I endometrial cancer patients. Systemic chemotherapy is typically reserved for women with disseminated primary disease or extrapelvic recurrence. Although the combination of cisplatin plus doxorubicin is commonly used, carboplatin plus paclitaxel represents an efficacious, low-toxicity regimen for managing advanced or recurrent endometrial cancer. Recently, a significant percentage of Type II uterine tumors have been found to overexpress the epidermal growth factor Type II receptor. Anti-HER-2/neu-targeted therapy might be a novel and attractive therapeutic strategy in patients harboring this biologically aggressive variant of endometrial cancer. 相似文献
992.
Myocardial infarction rate in acute pulmonary edema: noninvasive pressure support ventilation versus continuous positive airway pressure 总被引:12,自引:0,他引:12
Bellone A Monari A Cortellaro F Vettorello M Arlati S Coen D 《Critical care medicine》2004,32(9):1860-1865
OBJECTIVE: Noninvasive pressure support ventilation (NIPSV) delivered by face mask has proved an effective treatment for patients with acute pulmonary edema. However, an increase in acute myocardial infarction rate has been reported with this ventilation modality. We investigated whether the use of NIPSV increases the incidence of acute myocardial infarction compared with continuous positive airway pressure (CPAP) in patients with acute pulmonary edema. DESIGN: Randomized, prospective, controlled study. SETTING: Emergency Department, Niguarda Hospital of Milano (Italy). PATIENTS: Forty-six patients affected by acute pulmonary edema. INTERVENTIONS: The patients received either NIPSV (24 patients) or CPAP (22 patients) through a face mask. MEASUREMENTS AND MAIN RESULTS: Cardiac enzymes (myoglobin, creatine kinase isoenzyme MB, and troponin I) were determined and electrocardiographic and physiologic measurements made over the subsequent 36 hrs. No significant differences were observed in the incidence of acute myocardial infarction in the CPAP group (13.6%) compared with the NIPSV group (8.3%). Both modalities of noninvasive ventilation improved ventilation and vital signs in patients with acute pulmonary edema. Two patients of the NIPSV group (8.3%) and one of the CPAP group (4.5%) required endotracheal intubation because vital signs and arterial blood gases worsened 1 hr after the start of noninvasive ventilation. No significant differences were found in in-hospital mortality rate. CONCLUSIONS: NIPSV proved to be equally effective in improving vital signs and ventilation without increasing acute myocardial infarction rate in patients with nonischemic acute pulmonary edema in comparison to CPAP alone. However, because the study lacked statistical power and excluded patients with acute coronary syndromes, caution is still advised when applying NIPSV to the latter subgroup of patients. 相似文献
993.
Abbate C Giorgianni C Munaò F Beninato G D'Arrigo G D'Arrigo P Brecciaroli R 《La Medicina del lavoro》2006,97(1):13-19
BACKGROUND: Obesity is an international social problem. OBJECTIVES: This study was aimed at evaluating the relationship of overweight and obesity with social dynamics and correlated biological indicators. SUBJECTS AND METHODS: The study was carried out on a group of healthcare workers employed in a large hospital in the province of Messina (Sicily, Italy). A total of 1010 subjects (377 men and 633 women) aged between 16 and 64 years, living in the province of Messina since birth. The educational level, BMI (Body mass index), arterial blood pressure and ECG of each subject was examined. RESULTS: The results showed that 52% of the men and 66.5% of the women were of normal weight, while the men showed greater susceptibility to overweight (M 33.2% > F 16%). Obesity was found in both sexes (M 13.3%, F 13.6%). Moreover, it was observed that arterial blood pressure tends to increase with age and body weight, and that the incidence of overweight falls as educational level rises. CONCLUSIONS: The study supports the hypothesis that there is a growing incidence of overweight and obesity in subjects of working age employed in the healthcare sector. 相似文献
994.
Clerici CA Ferrari A Massimino M Luksch R Cefalo G Terenziani M Casanova M Spreafico F Polastri D Meazza C Podda M Fossati-Bellani F 《Tumori》2006,92(4):306-310
AIMS AND BACKGROUND: To assess the psychological needs of parents after the death of their child from cancer. METHODS: The study comprises a preliminary retrospective phase to identify parents who spontaneously contacted the medical staff, followed by a prospective phase in which families were contacted by telephone and were invited to a meeting. RESULTS: The retrospective study demonstrated that more than 50% of the families spontaneously sought contact with the department. In the prospective study, 17 families were contacted and the majority of them subsequently decided to come to the department for a talk. CONCLUSIONS: Our experience shows that parents have a strong need to have further contact with the team that took care of their children for months. In the process of coping with bereavement, anxiety and depression are common and not necessarily pathological, though there may be psychopathological reactions that can interfere with the parents' quality of life. 相似文献
995.
Cardy AH Little J McKean-Cowdin R Lijinsky W Choi NW Cordier S Filippini G Holly EA Lubin F McCredie M Mueller BA Peris-Bonet R Arslan A Preston-Martin S 《International journal of cancer. Journal international du cancer》2006,118(5):1302-1308
N-nitroso compounds (NOC) have been associated with carcinogenesis in a wide range of species, including humans. There is strong experimental data showing that nitrosamides (R(1)NNO.COR(2)), a type of NOC, are potent neuro-carcinogens when administered transplacentally. Some medications are a concentrated source of amides or amines, which in the presence of nitrites under normal acidic conditions of the stomach can form NOC. Therefore, these compounds, when ingested by women during pregnancy, may be important risk factors for tumors of the central nervous system in the offspring. The aim of the present study was to test the association between maternal use of medications that contain nitrosatable amines or amides and risk of primary childhood brain tumors (CBT). A case-control study was conducted, which included 1,218 cases and 2,223 population controls, recruited from 9 centers across North America, Europe and Australia. Analysis was conducted for all participants combined, by tumor type (astroglial, primitive neuroectodermal tumors and other glioma), and by age at diagnosis (< or =5 years; >5 years). There were no significant associations between maternal intake of medication containing nitrosatable amines or amides and CBT, for all participants combined and after stratification by age at diagnosis and histological subtype. This is the largest case-control study of CBT and maternal medications to date. Our data provide little support for an association between maternal use of medications that may form NOC and subsequent development of CBT in the offspring. 相似文献
996.
Pardini M Varaine F Iona E Arzumanian E Checchi F Oggioni MR Orefici G Fattorini L 《Journal of clinical microbiology》2005,43(1):442-444
Recovery of Mycobacterium tuberculosis from sputa treated with cetyl-pyridinium chloride (CPC) and stored for 20 +/- 9 days was significantly higher than that from sputa that were untreated and processed by the N-acetyl-L-cisteine-NaOH method. Addition of CPC is useful for isolation of M. tuberculosis from sputa subjected to long-term storage received from remote areas of the world. 相似文献
997.
998.
No evidence of association between CAG expansions and essential tremor in a large cohort of Italian patients 总被引:4,自引:0,他引:4
Pigullo S Di Maria E Marchese R Assini A Bellone E Scaglione C Vitale C Bonuccelli U Barone P Ajmar F Martinelli P Abbruzzese G Mandich P 《Journal of neural transmission (Vienna, Austria : 1996)》2001,108(3):297-304
Summary. Essential tremor (ET) is one of the most common movement disorders. However the pathogenesis is as yet unknown, although
a genetic cause has long been recognised. Clinical and molecular evidences suggested that the ET gene might contain a CAG
expanded region. In a cohort of Italian ET patients Repeat Expansion Detection (RED) approach did not demonstrate large CAG
expansions. We extended the study towards specific targets: the channel proteins hSKCa3 and CACNL1A4. Direct assessment of
CAG stretches within these two genes did not demonstrate any CAG expansion in affected subjects. Also a case-control analysis
failed to reveal any evidence of association, thus excluding these genes as a cause of ET.
Received August 14, 2000; accepted October 23, 2000 相似文献
999.
1000.