全文获取类型
收费全文 | 1163篇 |
免费 | 61篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 43篇 |
妇产科学 | 38篇 |
基础医学 | 166篇 |
口腔科学 | 12篇 |
临床医学 | 86篇 |
内科学 | 232篇 |
皮肤病学 | 77篇 |
神经病学 | 135篇 |
特种医学 | 54篇 |
外科学 | 101篇 |
综合类 | 11篇 |
一般理论 | 5篇 |
预防医学 | 75篇 |
眼科学 | 15篇 |
药学 | 109篇 |
中国医学 | 2篇 |
肿瘤学 | 66篇 |
出版年
2023年 | 9篇 |
2022年 | 11篇 |
2021年 | 20篇 |
2020年 | 13篇 |
2019年 | 13篇 |
2018年 | 24篇 |
2017年 | 19篇 |
2016年 | 27篇 |
2015年 | 31篇 |
2014年 | 43篇 |
2013年 | 63篇 |
2012年 | 66篇 |
2011年 | 72篇 |
2010年 | 53篇 |
2009年 | 39篇 |
2008年 | 71篇 |
2007年 | 64篇 |
2006年 | 80篇 |
2005年 | 84篇 |
2004年 | 58篇 |
2003年 | 53篇 |
2002年 | 55篇 |
2001年 | 15篇 |
2000年 | 19篇 |
1999年 | 26篇 |
1998年 | 18篇 |
1997年 | 6篇 |
1996年 | 6篇 |
1995年 | 5篇 |
1994年 | 9篇 |
1993年 | 6篇 |
1992年 | 9篇 |
1991年 | 15篇 |
1990年 | 15篇 |
1989年 | 15篇 |
1988年 | 12篇 |
1987年 | 5篇 |
1985年 | 10篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1981年 | 3篇 |
1979年 | 8篇 |
1977年 | 7篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1965年 | 4篇 |
排序方式: 共有1237条查询结果,搜索用时 31 毫秒
981.
Amir Kurtaran M.D. Thomas Pangerl Christian Scheuba M.D. Wolfgang Schima M.D. Ewald Schober M.D. Klaus Kaserer M.D. Bela Teleky M.D. Irene Virgolini M.D. 《The American journal of gastroenterology》1998,93(8):1375-1376
A case of intestinal splenosis in a splenectomized patient is presented. 111 In-DTPA-D-Phe-1-octreotide (111 In-OCT) scintigraphy, computed tomography, as well as magnetic resonance imaging suggested a tumor in the small intestine. The histopathogical finding after operation revealed an intestinal splenosis. This case illustrates that intestinal splenosis may mimic a tumor by 111 In-OCT scan. In a splenectomized patient, a splenosis should therefore be considered. 相似文献
982.
Smita I. Negi Ariel Brautbar Salim S. Virani Aashish Anand Eliana Polisecki Bela F. Asztalos Christie M. Ballantyne Ernst J. Schaefer Peter H. Jones 《Journal of clinical lipidology》2013,7(1):82-87
Tangier disease is a rare autosomal-recessive disorder caused by mutation in the ATP binding cassette transporter 1 (ABCA1) gene. Typically, Tangier disease manifests with symptoms and signs resulting from the deposition of cholesteryl esters in nonadipose tissues; chiefly, in peripheral nerves leading to neuropathy and in reticulo-endothelial organs, such as liver, spleen, lymph nodes, and tonsils, causing their enlargement and discoloration. An association with early cardiovascular disease can be variable. We describe a patient with a unique phenotype of Tangier disease from a novel splice site mutation in the ABCA1 gene that is associated with a central nervous system presentation resembling multiple sclerosis, and the presence of premature atherosclerosis. 相似文献
983.
Hugo Maia Jr Head of Research Kleber Pimentel Tânia M. Correia Silva Luíz A. R. Freitas Bela Zausner Célia Athayde 《Gynecological endocrinology》2013,29(4):219-224
Objectives.?To study the changes in aromatase, Ki-67 and cyclooxygenase-2 (COX-2) expression during the menstrual cycle in both endometrial polyps and normal endometria.Patients and methods.?Paraffin-embedded tissue samples from 118 premenopausal patients were submitted to immunohistochemistry for measurement of aromatase, COX-2 and Ki-67 expression. Fifty cases of endometrial polyps and 68 cases of disease-free endometrium were included.Results.?The presence of aromatase expression was significantly higher in endometrial polyps than in disease-free endometria. On the other hand, changes in COX-2 and Ki-67 expression followed a similar pattern during the menstrual cycle in both groups, expression peaking during the proliferative phase and falling during the late luteal phase.Conclusion.?A significantly higher proportion of endometrial polyps express aromatase compared with disease-free endometrium; however, no correlation was found between aromatase expression and changes in either Ki-67 or COX-2 expression during the menstrual cycle. 相似文献
984.
Palotás A Penke B Palotás M Kenderessy AS Kemény L Kis E Vincze G Janka Z Kálmán J 《Skin pharmacology and physiology》2004,17(4):195-199
BACKGROUND: Antipsychotics are widely used in the treatment of behavioral and psychological symptoms of dementia. A low frequency of Alzheimer's disease in patients with schizophrenia is reported, and it has been proposed that antipsychotic medications, such as haloperidol, may be responsible. Disruption of intracellular calcium levels is considered to play a key role in beta-amyloid-induced neurotoxicity in Alzheimer's disease. Haloperidol has also been reported to interact with calcium homeostasis through dopamine-2 and sigma-1 receptors, and other, yet unknown mechanisms. OBJECTIVE: Therefore, we investigated whether differences in the basal intracellular free calcium levels of cultured cutaneous fibroblasts--cells that do not express dopamine-2 and sigma-1 receptors--derived from sporadic Alzheimer patients and from age-matched control individuals after haloperidol treatment might be present. METHODS: Intracellular calcium level was measured in Fura-2AM-loaded human fibroblasts by dual wavelength spectrofluorimetry. RESULTS: Alzheimer cells exhibited significantly lower calcium level as compared to the control cultures. Exposure of fibroblasts to beta-amyloid peptide resulted in increased calcium concentration of the control cells, but not of Alzheimer fibroblasts. Co-incubation of cultures with a therapeutic dose of haloperidol blocked the beta-amyloid-induced elevation of calcium. CONCLUSION: This finding indicates that haloperidol efficiently countervails ionic imbalance and suggests that it may serve as a potential agent in alleviating neurotoxic effects of beta-amyloid peptide. 相似文献
985.
Mia Bierbaum Frances Rapport Gaston Arnolda Yvonne Tran Brona Nic Giolla Easpaig Kristiana Ludlow Robyn Clay-Williams Elizabeth Austin Bela Laginha Chi Yhun Lo Kate Churruca Lieke van Baar Karen Hutchinson Renuka Chittajallu Syeda Somyyah Owais Ruqaiya Nullwala Peter Hibbert Diana Fajardo Pulido Jeffrey Braithwaite 《Asia-Pacific Journal of Clinical Oncology》2023,19(6):618-644
Adherence to cancer treatment clinical practice guidelines (CPGs) varies enormously across Australia, despite being associated with improved patient outcomes. This systematic review aims to characterize adherence rates to active-cancer treatment CPGs in Australia and related factors to inform future implementation strategies. Five databases were systematically searched, abstracts were screened for eligibility, a full-text review and critical appraisal of eligible studies performed, and data extracted. A narrative synthesis of factors associated with adherence was conducted, and the median adherence rates within cancer streams calculated. A total of 21,031 abstracts were identified. After duplicates were removed, abstracts screened, and full texts reviewed, 20 studies focused on adherence to active-cancer treatment CPGs were included. Overall adherence rates ranged from 29% to 100%. Receipt of guideline recommended treatments was higher for patients who were younger (diffuse large B-cell lymphoma [DLBCL], colorectal, lung, and breast cancer); female (breast and lung cancer), and male (DLBCL and colorectal cancer); never smokers (DLBCL and lung cancer); non-Indigenous Australians (cervical and lung cancer); with less advanced stage disease (colorectal, lung, and cervical cancer), without comorbidities (DLBCL, colorectal, and lung cancer); with good-excellent Eastern Cooperative Oncology Group performance status (lung cancer); living in moderately accessible places (colon cancer); and; treated in metropolitan facilities (DLBLC, breast and colon cancer). This review characterized active-cancer treatment CPG adherence rates and associated factors in Australia. Future targeted CPG implementation strategies should account for these factors, to redress unwarranted variation particularly in vulnerable populations, and improve patient outcomes (Prospero number: CRD42020222962). 相似文献
986.
Aseptic surgical preparation for upper eyelid blepharoplasty via full‐face octenidine antiseptic without antibiotic medication shows effective prophylaxis against post‐surgical wound infection 下载免费PDF全文
Johannes Matiasek Philip Kienzl Gerlinde R Otti Bela R Turk Gabriel Djedovic Ulrich M Rieger 《International wound journal》2018,15(1):84-89
Blepharoplasty is the third most common plastic surgical procedure in the USA. Due to the emergence of multiresistant bacteria, optimising the antiseptic procedure is crucial. Choice of antiseptics plays an important role as they may cause skin irritation and colouring of disinfected areas. In this study, the use of the aqueous antiseptic octenisept® (octenidine) was evaluated in the outcome of blepharoplasties: incidence of wound dehiscence; haematoma; and infection in correlation with gender, medication, smoking habits and time of year. This retrospective surveillance study included 352 patients (median age 58·3 years). Skin disinfection was performed thrice prior to blepharoplasty. Sutures were removed on day 6. None of the patients suffered from wound infection. The total rate of wound dehiscence was 6·3%, with a higher ratio among male patients. Smokers and patients on anticoagulant medication showed a significantly higher incidence of wound dehiscence. Throughout the year, rates of wound dehiscence were highest in summer. Aseptic surgical preparation for blepharoplasty via full‐face scrub with octenisept® without oral antibiotic prophylaxis is well tolerated, with no report of wound infection, which may improve antibiotic stewardship as well as patient comfort. Elective upper eyelid blepharoplasty may ideally be performed in winter. 相似文献
987.
Attila Oláh Majid Alam Jérémy Chéret Nikolett Gréta Kis Zoltán Hegyi Attila Gábor Szöllősi Silvia Vidali Tamás Bíró Ralf Paus 《Experimental dermatology》2020,29(7):616-622
Epidermal energy metabolism is relevant to skin physiology, ageing and photodamage. While selected hormones stimulate epidermal keratinocyte mitochondrial activity, its negative regulation remains unknown. In several cell types, cannabinoid receptor 1 (CB1) is expressed both on the cell membrane (cmCB1) and on the mitochondrial outer membrane (mtCB1), where its stimulation directly suppresses mitochondrial functions. In the current pilot study, we investigated if CB1 is a negative regulator of human epidermal energy metabolism under physiological conditions. Using organ-cultured full-thickness human skin specimens of healthy individuals, we showed that antagonizing the homeostatic CB1 signalling by the administration of the CB1 inverse agonist AM251 increased respiratory chain complex I and II/IV activity. The effect was CB1-dependent, since the CB1-selective agonist arachidonyl-2'-chloroethylamide could prevent the effect. Moreover, the phenomenon was also reproduced by siRNA-mediated down-regulation of CB1. As revealed by the unaltered expression of several relevant markers (TFAM, VDAC1, MTCO1 and NDUFS4), modulation of CB1 signalling had no effect on the epidermal mitochondrial mass. Next, by using immunoelectron microscopy, we found that human epidermal keratinocytes express both cmCB1 and mtCB1. Finally, by using equipotent extracellularly restricted (hemopressin) as well as cell-permeable (AM251) inverse agonists, we found that mitochondrial activity is most likely exclusively regulated by mtCB1. Thus, our data identify mtCB1 as a novel negative regulator of keratinocyte mitochondrial activity in intact human epidermis, and raise the question, whether topical therapeutic interventions capable of selectively activating mtCB1 can reduce excessive mitochondrial ROS production resulting from dysregulated mitochondrial activity during skin ageing or photodamage. 相似文献
988.
989.
Andras Bikov Mrton Kolossvry Adam L. Jermendy Zsofia D. Drobni Adam D. Tarnoki David L. Tarnoki Bianka Forg Daniel T. Kovacs Gyorgy Losonczy Laszlo Kunos Szilard Voros Bela Merkely Pal Maurovich‐Horvat 《Journal of sleep research》2019,28(5)
Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. Previous studies have assessed the relationship between OSA and coronary artery disease (CAD) using coronary artery calcium score (CAC) measurements. However, limited data are available regarding the association of OSA with non‐calcified plaque burden. We therefore aimed to assess the relationship between CAD severity as assessed by coronary computed tomography angiography (CTA) and OSA. Forty‐one adult subjects (59 ± 9 years, 15 men) underwent a 256‐slice coronary CTA, which was followed by a diagnostic attended cardiorespiratory polygraphy (n = 13) or polysomnography (n = 28). Segment involvement score (SIS), segment stenosis score (SSS) and CAC were used to quantify total CAD burden. Correlation analysis was used to assess potential associations between CAD and OSA. Twenty‐two patients were diagnosed with OSA. SIS and SSS were elevated in OSA (2.90 ± 2.78 versus 1.79 ± 2.39 and 4.91 ± 5.94 versus 1.79 ± 4.54, OSA versus controls, SIS and SSS respectively, both p < 0.01) and correlated with OSA severity as measured by the apnea‐hypopnea index (AHI, r = 0.41 and 0.43, p < 0.01) and oxygen desaturation index (ODI, r = 0.45 and 0.46, p < 0.01). However, no significant correlation was observed between CAC and OSA. Compared to CAC, SIS and SSS provide additional information on coronary plaque burden in OSA, which shows a significant association with OSA. 相似文献
990.
Lili Magyari Erzsebet Kovesdi Patricia Sarlos Andras Javorhazy Katalin Sumegi Bela Melegh 《World journal of gastroenterology : WJG》2014,20(12):3208-3222
Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals.Genetic markers are associated with disease phenotype and long-term evolution,but their value in everyday clinical practice is limited at the moment.IBD has a clear immunological background and interleukins play key role in the process.Almost130 original papers were revised including meta-analysis.It is clear these data are very important for understanding the base of the disease,especially in terms of clinical utility and validity,but text often do not available for the doctors use these in the clinical practice nowadays.We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD,performing an electronic search of PubMed Database from publications of the last 10 years,and used the following medical subject heading terms and/or text words:IBD,CD,UC,interleukins and polymorphisms. 相似文献