全文获取类型
收费全文 | 2171篇 |
免费 | 111篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 129篇 |
妇产科学 | 49篇 |
基础医学 | 352篇 |
口腔科学 | 145篇 |
临床医学 | 160篇 |
内科学 | 470篇 |
皮肤病学 | 57篇 |
神经病学 | 169篇 |
特种医学 | 52篇 |
外国民族医学 | 2篇 |
外科学 | 192篇 |
综合类 | 5篇 |
预防医学 | 210篇 |
眼科学 | 18篇 |
药学 | 138篇 |
中国医学 | 4篇 |
肿瘤学 | 118篇 |
出版年
2023年 | 7篇 |
2022年 | 15篇 |
2021年 | 92篇 |
2020年 | 26篇 |
2019年 | 69篇 |
2018年 | 112篇 |
2017年 | 73篇 |
2016年 | 58篇 |
2015年 | 66篇 |
2014年 | 71篇 |
2013年 | 87篇 |
2012年 | 164篇 |
2011年 | 204篇 |
2010年 | 99篇 |
2009年 | 67篇 |
2008年 | 130篇 |
2007年 | 141篇 |
2006年 | 130篇 |
2005年 | 114篇 |
2004年 | 92篇 |
2003年 | 98篇 |
2002年 | 66篇 |
2001年 | 39篇 |
2000年 | 31篇 |
1999年 | 26篇 |
1998年 | 7篇 |
1997年 | 9篇 |
1995年 | 5篇 |
1994年 | 3篇 |
1992年 | 19篇 |
1991年 | 19篇 |
1990年 | 17篇 |
1989年 | 16篇 |
1988年 | 15篇 |
1987年 | 10篇 |
1986年 | 9篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 7篇 |
1979年 | 8篇 |
1978年 | 3篇 |
1976年 | 3篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 4篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1967年 | 3篇 |
1965年 | 2篇 |
1930年 | 3篇 |
排序方式: 共有2288条查询结果,搜索用时 0 毫秒
101.
Ringer Ariana Ruffino Juan Pablo Leiva Rodolfo Cuadranti Nadia Argento María Cecilia Martínez María Florencia Rolla Ignacio Chulibert Serenela Carbone Daniela Palatnik Mariano Cortese Maria Noel Lagrutta Mariana Córdoba Laura González Florencia Belén Pacini María Florencia Villar Silvina Raquel Águila Damian Bottasso Oscar Adelmo Pérez Ana Rosa Abdala Marcelo 《Clinical rheumatology》2021,40(7):2955-2963
Clinical Rheumatology - Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic... 相似文献
102.
If customary drug mediated immunosuppressive therapy leads to intolerable side effects or is inefficient, extracorporeal elimination and untargeted or targeted immunoglobin therapy modulating the immune response are taken into consideration for the treatment of patients with autoimmune diseases. Both elimination and immunoglobulin therapy, are not alternatives but appear to act complementary, if sequentially applied. Selective immunoadsorption is increasingly applied for extracorporeal elimination and is able to replace plasma exchange therapy. Both, hydrophobic interaction chromatography and affinity chromatography are effective in given clinical conditions. Therapeutic affinity chromatography appears to be superior to hydrophobic interaction chromatography, if an effective, rapid elimination of the disease promoting agent is desired. Experience with therapeutic chromatography collected in the past, indicates that a rapid elimination of immunoglobulins and the subsequent intravenous infusion of 7S immunoglobulin is superior to elimination or untargeted immunomodulation alone. These experimental approaches lead to an extension of the available treatment modalities. However, controlled trials rather than anecdotal reports are needed, to provide substantial information. 相似文献
103.
Protein A adsorption (Immunosorba, Excorim, Sweden) is a potent tool for the rapid removal of antibodies from the circulation. In comparison to conventional plasma exchange therapy, Protein A adsorption offers the advantage of processing large amounts of plasma, removing up to 87% of the initial level of IgG in one session without a clinically significant loss of fibrinogen. So far 61 treatments have been carried out in our department without serious side effects. 相似文献
104.
105.
106.
107.
108.
Arístides A. Pochettino María Belén Hapon Silvana M. Biolatto María José Madariaga Graciela A. Jahn Cintia N. Konjuh 《Drug and chemical toxicology》2016,39(4):392-399
The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce a wide range of adverse effects on animal and human health. The aim of the current study was to evaluate the effects of pre- and postnatal exposure to 2,4-D on rat ventral prostate (VP). Pregnant rats were exposed daily to oral doses of 70?mg/kg/day of 2,4-D from 16 days of gestation up to 23 days after delivery. Then, the treated groups (n?=?8) were fed with a 2,4-D added diet until sacrificed by decapitation on postnatal day (PND) 45, 60, or 90. Morphometric studies were performed and androgen receptor (AR) protein levels in the VP were determined. AR, insulin-like growth factor-I (IGF-1) and insulin-like growth factor-I receptor (IGF-1R) mRNA expression in the VP along with testosterone (T), dihydroxytestosterone (DHT), growth hormone (GH) and IGF-1 serum levels were also determined to ascertain whether these parameters were differentially affected. Results of this study showed that 2,4-D exposure during gestation and until adulthood altered development of the prostate gland in male rats, delaying it at early ages while increasing its size in adults, indicate that 2,4-D could behave as endocrine disruptors (EDs). 相似文献
109.
Effect of Ki‐67 on Immunohistochemical Classification of Luminal A to Luminal B Subtypes of Breast Carcinoma 下载免费PDF全文
Magno Belém Cirqueira BSc MSc Marise Amaral Rebouças Moreira MD PhD Leonardo Ribeiro Soares MD Maria‐Helena Tavares Vilela MD MSc Ruffo Freitas‐Junior MD PhD 《The breast journal》2015,21(5):465-472
It has recently been proposed to include an immunohistochemical marker of cell proliferation, Ki‐67, as an element with which to classify the molecular subtypes of breast cancer. The objective of this study was to evaluate the effect of the introduction of the Ki‐67 marker on the molecular classification of breast cancer by immunohistochemistry. This study was performed on 234 cases of invasive ductal carcinoma of the breast submitted to two immunohistochemical classification panels, one including Ki‐67 and the other not. The data obtained with the two classifications were correlated with well‐established prognostic factors such as histologic grade, the number of lymph nodes affected and tumor size. The molecular classification without Ki‐67 identified: 136 cases of luminal A (58.1%), 19 cases of luminal B (8.1%), 27 cases of human epidermal growth‐factor receptor 2 overexpressing (11.5%), 27 cases of basal‐like (11.5%), and 25 cases of nonbasal‐like triple‐negative tumors (10.7%). When Ki‐67 was included, this situation changed significantly, with the following cases being identified: 72 cases of luminal A (30.8%) and 83 cases of luminal B tumors (35.5%), resulting in a Kappa score of 0.216. Evaluation of correlations between the luminal A and luminal B tumor subtypes and the selected prognostic factors showed a statistically significant difference only when Ki‐67 was included and only with respect to histologic grade (p < 0.001). The new classification with Ki‐67 significantly altered the prevalence of the luminal A and luminal B subtypes and improved correlation with the histologic grade. 相似文献
110.
María Belén Acevedo J. Christopher Eagon Bruce D. Bartholow Samuel Klein Kathleen K. Bucholz Marta Yanina Pepino 《Surgery for obesity and related diseases》2018,14(3):277-283