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José Tiago Sequeira Lopes da Silva Olga González Casas Verónica Bejarano Moguel Maria Lobo Pascua Antonio López-Santamaría Redondo Remigio Cordero Torres 《Gastroenterologia y hepatologia》2013
Somatostatin and somatostatin analogues are considered very useful for the treatment of hormone producing tumors and acute variceal bleeding. They have also been proposed for the treatment of acute pancreatitis and for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis although clinical trials have failed to show any efficacy. The authors report the case of a 45-year-old man, recently diagnosed of acromegaly, which developed an acute pancreatitis shortly after his first injection of lanreotide autogel. The patient developed a severe dilatation of his hypocontractile gallbladder with distension of the intra and extrahepatic biliary ducts, the choledochus and the main pancreatic duct, without lithiasis or other abnormalities at the papilla, which resolved spontaneously in a month. We consider that lanreotide most likely induced a functional spasm of the Sphincter of Oddi, with impairment of the biliary-pancreatic outflow, leading to an acute pancreatitis, and review the literature concerning this drug related pancreatitis. 相似文献
83.
Concepción García-Gómez Elvira Esteban Beatriz Sánchez-Pardo María Dolores Fernández 《Ecotoxicology (London, England)》2014,23(7):1195-1209
The interactions and relevance of the soil (total and available) concentrations, accumulation, and acute toxicity of several essential and non-essential trace elements were investigated to determine their importance in environmental soil assessment. Three plant species (T. aestivum, R. sativum, and V. sativa) and E. fetida were simultaneously exposed for 21 days to long-term contaminated soils collected from the surroundings of an abandoned pyrite mine. The soils presented different levels of As and metals, mainly Zn and Cu, and were tested at different soil concentrations [12.5, 25, 50, and 100 % of contaminated soil/soil (w/w)] to increase the range of total and available soil concentrations necessary for the study. The total concentrations in the soils (of both As and metals) were better predictors of earthworm uptake than were the available concentrations. In plants, the accumulation of metals was related to the available concentrations of Zn and Cu, which could indicate that plants and earthworms accumulate elements from different pools of soil contaminants. Moreover, Zn and Cu, which are essential elements, showed controlled uptake at low concentrations. The external metal concentrations predicted earthworm mortality, whereas in plants, the effects on growth were correlated to the As and metal contents in the plants. In general, the bioaccumulation factors were lower at higher exposure levels, which implies the existence of auto-regulation in the uptake of both essential and non-essential elements by plants and earthworms. 相似文献
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Aniel J. L. Brambila-Tapia Jorge I. G��mez-Nava Laura Gonz��lez-L��pez Lucila Sandoval-Ram��rez Julio Med��na-D��az Montserrat Maldonado Sergio R. Gutierrez-Ure?a Gloria Mart��nez-Bonilla Beatriz T. Mart��n-M��rquez M��nica V��zquez del Mercado Arnulfo Nava-Zavala Jos�� F. Mu?oz-Valle Mario Salazar-P��ramo Ingrid P. D��valos-Rodr��guez 《Rheumatology international》2011,31(8):1065-1068
The objective of this study is to establish whether there is an association between the presence of FCGR3A V(176) polymorphism with SLE or its manifestations. We included 94 patients according to the 1982 ACR criteria as well as 98 controls matched by age and gender. The 11 ACR diagnostic criteria were analyzed on the clinical files. The polymorphism FCGR3A V(176) was determined by direct sequencing. There was not an association between the polymorphism FCGR3A V(176) with SLE or its main manifestations. The allelic frequency for F(176) was: 0.80 and 0.72 in cases and controls, respectively (P?=?0.09, IC95%: 0.42?C1.07); and the genotypic frequency in the group of cases was: 0.65 for homozygotes F(176)/F(176), 0.30 for heterozygotes and 0.05 for the homozygotes V(176)/V(176), while for the control group it was 0.53, 0.39 and 0.08, respectively. The polymorphism FCGR3A V(176) is not associated with SLE or any of its manifestations in patients with SLE from the West of Mexico. 相似文献
86.
Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function 下载免费PDF全文
Miguel Mendivil‐Perez Viviana Soto‐Mercado Ana Guerra‐Librero Beatriz I. Fernandez‐Gil Javier Florido Ying‐Qiang Shen Miguel A. Tejada Vivian Capilla‐Gonzalez Iryna Rusanova José M. Garcia‐Verdugo Darío Acuña‐Castroviejo Luis Carlos López Carlos Velez‐Pardo Marlene Jimenez‐Del‐Rio José M. Ferrer Germaine Escames 《Journal of pineal research》2017,63(2)
Neural stem cells (NSCs) are regarded as a promising therapeutic approach to protecting and restoring damaged neurons in neurodegenerative diseases (NDs) such as Parkinson's disease and Alzheimer's disease (PD and AD, respectively). However, new research suggests that NSC differentiation is required to make this strategy effective. Several studies have demonstrated that melatonin increases mature neuronal markers, which reflects NSC differentiation into neurons. Nevertheless, the possible involvement of mitochondria in the effects of melatonin during NSC differentiation has not yet been fully established. We therefore tested the impact of melatonin on NSC proliferation and differentiation in an attempt to determine whether these actions depend on modulating mitochondrial activity. We measured proliferation and differentiation markers, mitochondrial structural and functional parameters as well as oxidative stress indicators and also evaluated cell transplant engraftment. This enabled us to show that melatonin (25 μM) induces NSC differentiation into oligodendrocytes and neurons. These effects depend on increased mitochondrial mass/DNA/complexes, mitochondrial respiration, and membrane potential as well as ATP synthesis in NSCs. It is also interesting to note that melatonin prevented oxidative stress caused by high levels of mitochondrial activity. Finally, we found that melatonin enriches NSC engraftment in the ND mouse model following transplantation. We concluded that a combined therapy involving transplantation of NSCs pretreated with pharmacological doses of melatonin could efficiently restore neuronal cell populations in PD and AD mouse models depending on mitochondrial activity promotion. 相似文献
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Laura Pérez-Egido María Antonia García-Casillas Isabel Simal María Fanjul Agustin Cañizo Julio A. Cerdá Beatriz Fernandez Manuel de la Torre Javier Ordoñez Juan Carlos de Agustin 《Journal of pediatric surgery》2019,54(4):693-695