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61.
62.
63.
TT virus infection and genotype distribution in blood donors and a group of patients from Turkey 总被引:3,自引:0,他引:3
Erensoy S Sayiner AA Türkoğlu S Canatan D Akarca US Sertöz R Ozacar T Batur Y Badur S Bilgiç A 《Infection》2002,30(5):299-302
Background: TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the
clinical importance is unclear. We aimed to determine the genotypes of TTV isolates foung in blood donors and different patient
groups from the western part of Turkey.
Materials and Methods: TT DNA was investigated in serum samples of 91 volunteer blood donors (BD), 105 thalassemia (TH) patients, ten patients with
fulminant hepatitis (FH) and 16 hemodialysis (HD) patients by heminested PCR using primers NG059, NG061 and NG063 from the
ORF1 region. 39 isolates were genotyped by analyzing the partial sequence of ORF1.
Results: TTV DNA was found in 75% of HD, 80% of FH, 61% of TH patients and in 51.6% of BD. Among the sequenced isolates, 14 (35.9%)
belonged to genotype 1 (G1) and 25 (64.1%) belonged to genotype 2 (G2). Among the G2 sequences, 22 were grouped as G2c.
Conclusion: TTV infection was common in the population studied, even with moderately sensitive primers. G2 was the major genotype of
the studied population without any significant differences in distribution between various patient groups and BD.
Received: December 27, 2001 · Revision accepted: April 4, 2002
S. Erensoy (corresponding author) 相似文献
64.
Harun Arslan Alpaslan Yavuz Ferda İlgen Abdurrahman Aycan Mesut Ozgokce Hüseyin Akdeniz Abdussamet Batur 《Journal of Medical Ultrasonics》2018,45(3):453-459
Objectives
The aim of the present study was to quantify the stiffness of the median nerve (MN) at the carpal tunnel inlet by acoustic radiation force impulse (ARFI) elastography and to evaluate whether ARFI can be used in diagnosis and staging of carpal tunnel syndrome (CTS).Methods
Sonographic examinations of 96 wrists in 50 patients were included in the study. The cross-sectional area and stiffness of the MN were quantitatively measured by B-mode ultrasonography (USG) and ARFI. The findings of CTS were assigned to four groups: (I) normal (n = 21), (II) mild (n = 39), (III) moderate (n = 38), and (IV) severe (n = 19). The differences between CTS patients and controls and the differences in electrodiagnostic tests among subgroups were statistically compared. ROC analysis was performed to determine the cut-off values between subgroups.Results
Bilateral CTS was present in 46 patients (92 wrists) and unilateral CTS in four patients. Of the 96 nerves in the 50 symptomatic “idiopathic CTS” patients (48 women, 2 men; mean age 45.9 years, range 23–73 years), 39 (40.4%) were mild, 38 (39.8%) were moderate, and 19 (19.8%) were severely affected. When compared to controls, MN stiffness was significantly higher in the CTS group (P < 0.001); furthermore, it was higher in the severe or extreme severity group than the mild or moderate severity group (P < 0.001). A 3.250 m/s cut-off value on ARFI revealed sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 81, 82, 95.1, 50, and 82%, respectively.Conclusion
The MN stiffness measured by ARFI elastography is significantly higher in patients with CTS then in controls. ARFI elastography appears to be a highly efficient imaging modality for the diagnosis and staging of these patients.65.
Batur MK Aksöyek S Oto A Yildirir A Ozer N Atalar E Aytemir K Kabakci G Ovünç K Ozmen F Kes S 《Clinical cardiology》1999,22(2):103-106
BACKGROUND: Several studies related to cardiac events including sudden death have shown a peak incidence in the early morning hours. It has also been known that acute ischemia is a potent stimulus to increased dispersion of repolarization and development of malignant arrhythmias. HYPOTHESIS: The purpose of the present study was to investigate diurnal variations of corrected QT dispersion (QTcD) in patients with coronary artery disease (CAD) (Group 1) compared with controls with normal coronary angiograms (Group 2). METHODS: We investigated a total of 110 patients who had been referred for coronary angiography, of whom 62 (42 men, 20 women; age 55 +/- 7 years) had double- or triple-vessel disease, and of whom 48 (31 men, 17 women; age 54 +/- 9 years) had normal coronary angiograms. QTcD measurements were calculated from a 12-lead resting electrocardiogram (ECG) during sinus rhythm. These ECGs were obtained for each patient in the morning, at noon, in the evening, and at night on the day after performance of coronary angiography. QTcD was significantly greater in patients with abnormal coronary angiograms (Group 1) than in patients with angiographically documented normal coronary arteries (Group 2). This difference appeared to be more prominent in the morning hours (p < 0.001) than at other times. QTcD in the evening and night hours was not statistically different (p > 0.05) between both groups. We also compared intragroup QTcD values: QTcD values were significantly increased in the morning hours and were more prominent in Group 1 than in Group 2. CONCLUSIONS: Our data suggest that QTcD has a circadian variation with an increase in the morning hours, especially in patients with coronary artery disease. This finding was thought to be an explanation for the role played by sympathetic nervous system in the occurrence of acute cardiac events and sudden death during these hours. 相似文献
66.
To investigate the effects of levosimendan, a positive inotropic agent, on the new heart failure markers immunoglobulin free
light chains kappa and lambda (FLC-κ and FLC-λ) in decompensated chronic heart failure (HF), 59 patients with New York Heart
Association (NYHA) class III–IV HF were enrolled. Patients were randomized into levosimendan (n = 31) and standard HF treatment (n = 29) groups. Serum FLC-κ and FLC-λ, brain natriuretic peptide (BNP), and ejection fraction (EF) were measured before treatment
and on the 5th day of treatment initiation. Forty-two percent of subjects were females (n = 25) and overall mean age was 64.1 ± 10.7 years. FLC-κ (P < 0.05) and FLC-λ (P < 0.05) were significantly decreased in the levosimendan group compared to baseline, but no difference in either marker in
the standard treatment group was observed. Pre- and post-treatment FLC-κ/FLC-λ ratios in both groups were similar, whereas
FLC-κ and FLC-λ levels and the FLC-κ/FLC-λ ratio showed no significant correlation with NYHA class, brain natriuretic peptide
(BNP) and ejection fraction (EF) levels; and BNP and EF changes after the treatment. Symptomatic improvement in the levosimendan
group according to the NYHA class was significantly better than in the standard treatment group (P = 0.044). While 55.2% of patients in the levosimendan group showed a 1-degree shift to lower NYHA classes, 10.3% showed a
2-degree decrease. In conclusion, levosimendan caused short-term hemodynamic and symptomatic improvements, with a more pronounced
decrease in FLC levels in patients with advanced decompensated HF. 相似文献
67.
68.
Akyildiz M Gunsar F Ersoz G Karasu Z Ilter T Batur Y Akarca U 《Digestive diseases and sciences》2007,52(12):3444-3447
We studied clinical and laboratory effects of 3 months of lamivudine with adefovir combination and adefovir dipivoxil (AD)
alone in the treatment of patients with lamivudine-resistant hepatitis B virus (HBV) infection. Eligible patients were hepatitis
B surface antigen-positive men and women with compensated liver disease who were given lamivudine at least more than 6 months
and had HBV polymerase gene mutation. Patients were assigned to receive adefovir 10 mg/day (Group 1) or adefovir 10 mg once
daily and lamivudine 100 mg once daily combination during first 3 months, and then stopped lamivudine and continued adefovir
(Group 2).
Median age was 48 years (34 males and 20 females, and 35 were HBeAg-negative). Baseline median ALT, AST, and HBV DNA levels
were 66 IU/l, 49 IU/l, and 6.7 log10 copy/ml, respectively. Median adefovir therapy time and ALT normalization time were 9 and 3.5 months, respectively. There
was no significant difference between groups according to the baseline HBV DNA, ALT, HBe Ag status, age, gender, and lamivudine
resistance time. Virological and biochemical responses were similar in both groups during therapy. Two patients (8%) had ALT
flare more than five times upper limit of normal without any clinical decompensation in Group 1. Mild ALT elevation according
to baseline levels were found in 8 (27.6%) and 4 (17.4%) patients, respectively, in Group 2 and Group 1, and no statistically
significance between two groups.
In conclusion, this study showed that it is not necessary to continue lamivudine therapy while switching to AD therapy. Adefovir
alone is effective in the treatment of patients with lamivudine resistant HBV infection and compensated liver disease, without
significant clinical and laboratory flares. However, it is not easy to say that switching to AD with cessation of lamivudine
is safe, because the study population is not enough for precise conclusion and resistance may be a considerable problem against
AD in patients using long-term treatment. 相似文献
69.
Nevin Oruc Omer Ozutemiz Gul Yuce Ulus S Akarca Galip Ersoz Fulya Gunsar Yucel Batur 《BMC gastroenterology》2009,9(1):16-5
Background
Both C reactive protein (CRP) and procalcitonin (PCT) are well known acute phase reactant proteins. CRP was reported to increase in metabolic syndrome and type-2 diabetes. Similarly altered level of serum PCT was found in chronic liver diseases and cirrhosis. The liver is considered the main source of CRP and a source of PCT, however, the serum PCT and CRP levels in non-alcoholic fatty liver disease (NAFLD) were not compared previously. Therefore we aimed to study the diagnostic and discriminative role of serum PCT and CRP in NAFLD. 相似文献70.