全文获取类型
收费全文 | 306篇 |
免费 | 29篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 24篇 |
临床医学 | 25篇 |
内科学 | 214篇 |
皮肤病学 | 5篇 |
神经病学 | 15篇 |
特种医学 | 1篇 |
外科学 | 16篇 |
预防医学 | 23篇 |
药学 | 25篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 6篇 |
2017年 | 7篇 |
2016年 | 15篇 |
2015年 | 9篇 |
2014年 | 16篇 |
2013年 | 31篇 |
2012年 | 23篇 |
2011年 | 16篇 |
2010年 | 8篇 |
2009年 | 4篇 |
2008年 | 9篇 |
2007年 | 25篇 |
2006年 | 19篇 |
2005年 | 21篇 |
2004年 | 17篇 |
2003年 | 13篇 |
2002年 | 7篇 |
2001年 | 4篇 |
2000年 | 11篇 |
1999年 | 7篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 2篇 |
1995年 | 7篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 1篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1966年 | 1篇 |
1963年 | 4篇 |
1962年 | 3篇 |
排序方式: 共有357条查询结果,搜索用时 31 毫秒
11.
Bassotti G Villanacci V Nascimbeni R Cadei M Manenti S Antonelli E Fanini L Salerni B 《Digestive diseases and sciences》2012,57(1):65-71
Background
Mast cells are involved in visceral hypersensitivity and motor activity of the gastrointestinal tract. However, there is almost no information concerning mast cells in constipated patients. 相似文献12.
Lupi A Secco GG Rognoni A Rossi L Lazzero M Nardi F Rolla R Bellomo G Bongo AS Di Mario C 《Journal of thrombosis and thrombolysis》2012,33(4):308-317
Plasma fibrinogen levels influence restenosis following elective percutaneous coronary intervention (PCI) for stable angina.
It is unknown whether the same is true in the setting of primary PCI. The aim of the study was therefore to assess whether
fibrinogen levels were associated to 6-month in-stent restenosis (ISR) in STEMI patients undergoing successful primary PCI.
From January 2003 to October 2004, 267 patients were admitted to our Institution for STEMI and treated by primary PCI. Of
these, 171 patients met the inclusion criteria and were enrolled in our study. Fibrinogen levels were assessed at admission,
12 h, 24 h, 48 h, 72 h following PCI and at discharge. Six-month angiographic follow-up was 100% complete. Subjects with 6-month
ISR showed higher fibrinogen levels than patients without ISR. Patients in the upper fibrinogen tertile showed a higher 6-month
incidence of symptoms and/or inducible myocardial ischemia (27.1% vs. 7.1%, P = 0.006) and a larger late lumen loss (1.3 ± 0.8 vs. 1.0 ± 0.9 mm, P = 0.049). Logistic regression analysis demonstrated a significant and independent association between fibrinogen levels and
ISR. Our study suggests that increased plasma fibrinogen levels are related to ISR in STEMI patients undergoing primary PCI.
Larger studies are warranted to assess the prognostic value of fibrinogen over harder end-points. 相似文献
13.
14.
15.
16.
Raffaele Manta Marzio Frazzoni Rita Conigliaro Livia Maccio Gianlugi Melotti Emanuele Dabizzi Helga Bertani Mauro Manno Danilo Castellani Vincenzo Villanacci Gabrio Bassotti 《Surgical endoscopy》2013,27(5):1569-1572
Background
SpyGlass® single-operator peroral cholangioscopy appears to be a promising technique to overcome some limitations of conventional peroral cholangioscopy. We aimed to prospectively evaluate the SpyGlass system in a cohort of patients with indeterminate biliary lesions.Methods
Patients with indeterminate strictures or filling defects at endoscopic retrograde cholangiopancreatography (ERCP) were consecutively enrolled. After SpyGlass visual evaluation, targeted biopsies were taken with the SpyBite® and histopathological assessment was made by two experienced gastrointestinal pathologists. SpyBite-targeted biopsy results were evaluated by assessing agreement with surgical specimens and by evaluation of final, clinical follow-up-based diagnosis.Results
Fifty-two patients participated in the study. In 7 cases, definite diagnosis (stones, varices) was made by SpyGlass endoscopic evaluation. In 42 of the remaining 45 cases, material suitable for histopathology assessment was provided by the SpyBite. Overall, a definite diagnosis was made in 49 (7 + 42; 94 %) cases. Agreement of SpyBite biopsy results with surgical specimen diagnosis was found in 38/42 (90 %) cases; sensitivity, specificity, and positive and negative predictive values were 88, 94, 96, and 85 %, respectively. Procedure-related complications consisted of one case of mild cholangitis and one case of mild pancreatitis.Conclusions
In our series, the SpyGlass system allowed adequate biopsy sampling and definite diagnosis with high accuracy in the vast majority of patients with indeterminate biliary lesions. Its use was associated with a low complication rate. Further refinements of the technique are warranted, but the SpyGlass system has the potential to become a diagnostic standard for the assessment of indeterminate biliary lesions. 相似文献17.
18.
C. Eller-Vainicher A. Bassotti A. Imeraj E. Cairoli F. M. Ulivieri F. Cortini M. Dubini B. Marinelli A. Spada I. Chiodini 《Osteoporosis international》2016,27(8):2525-2531
Summary
The Ehlers-Danlos syndrome is characterized by abnormal connective tissue but bone involvement is debated. We found a reduced BMD and bone quality and increased prevalence of asymptomatic vertebral fractures in eugonadal patients with Ehlers-Danlos syndrome. These findings suggest the need of a bone health evaluation in these patients.Introduction
The Ehlers-Danlos (EDS) syndrome is characterized by abnormalities of the connective tissue leading to ligamentous laxity and skin and tissue fragility. We evaluated the bone metabolism, bone mineral density (BMD) and bone quality (measured by trabecular bone score, TBS), and the prevalence of vertebral fractures (VFx) in a group of eugonadal adult EDS patients.Methods
Fifty consecutive Caucasian patients, aged 30–50 years (36 females, 14 males) with classical or hypermobility EDS and 50 age-, gender-, and body mass index (BMI)-matched control subjects were enrolled. In all subjects’ calcium-phosphorous metabolism, bone turnover, BMD at the lumbar spine (LS) and femur (femoral neck, FN and total femur, FT) and TBS by dual-energy X-ray absorptiometry, and the VFx presence by spine radiograph were assessed.Results
Patients showed reduced BMD (Z-scores LS ?0.45?±?1.00, FN ?0.56?±?1.01, FT ?0.58?±?0.92) and TBS (1.299?±?0.111) and increased prevalence of morphometric VFx (32 %) than controls (Z-scores LS 0.09?±?1.22, FN 0.01?±?0.97, FT 0.08?±?0.89; TBS 1.382?±?0.176; VFx 8 %, p <0.05 for all comparisons), while vitamin D levels, calcium-phosphorous metabolism, and bone turnover were comparable. Fractured EDS patients showed lower TBS values than non-fractured ones (1.245?±?0.138 vs 1.325?±?0.086, p?<?0.05), despite comparable BMD. In EDS patients, the VFx presence was significantly associated with TBS even after adjusting for sex, age, BMD, EDS type, and falls frequency.Conclusions
EDS patients have reduced BMD and bone quality (as measured by TBS) and increased prevalence of VFx.19.
Sensory retraining is key to biofeedback therapy for formed stool fecal incontinence 总被引:11,自引:0,他引:11
G. Chiarioni M.D. G. Bassotti M.D. Samuela Stegagnini M.D. I. Vantini M.D. W.E. Whitehead Ph.D. 《The American journal of gastroenterology》2002,97(1):109-117
OBJECTIVES: Biofeedback is a nonsurgical treatment that reportedly produces good results in 65-75% of fecally incontinent patients. However, previous studies have not ruled out nonspecific treatment effects. It is also unknown whether biofeedback works primarily by improving the strength of the striated pelvic floor muscles or by improving the rectal perception. We aimed to 1) evaluate the efficacy of biofeedback in formed-stool fecal incontinence, 2) assess the relative contribution of sensory and strength retraining to biofeedback outcomes, and 3) identify patient characteristics that predict a good response to treatment. METHODS: Twenty-four patients with frequent (at least once a week) solid-stool incontinence were provided with three to four biofeedback sessions. They were taught to squeeze in response to progressively weaker rectal distentions. Patients were re-evaluated by anorectal manometry and symptom diary 3 months after completing training and by diary and interview 6-12 months after training. RESULTS: Seventeen (71%) were classified responders; 13 became continent and four reduced incontinence frequency by at least 75%. Clinical improvements were maintained at 12-month follow-up. At 3-month follow-up, responders had significantly lower thresholds for perception of rectal distention and for sphincter contraction, but squeeze pressures did not significantly differ from those of nonresponders. Baseline measures that predicted a favorable response were sensory threshold (50 ml or less), urge threshold (100 ml or less), lower threshold for sphincter contraction, and lower threshold for the rectoanal inhibitory reflex; neither anal squeeze pressure nor severity of incontinence predicted treatment outcome. CONCLUSIONS: In solid-stool fecal incontinence biofeedback training effects are robust and seem not to be explained by expectancy or nonspecific treatment effect. Sensory retraining appears to be more relevant than strength training to the success of biofeedback. 相似文献
20.
Nifedipine Reduces the Colonic Motor Response to Eating in Patients with the Irritable Colon Syndrome 总被引:3,自引:0,他引:3
Francesco Narducci Gabrio Bassotti Manuela Gaburri Ferruccio Farroni Antonio Morelli 《The American journal of gastroenterology》1985,80(5):317-319
Patients with the irritable colon syndrome have an exaggerated and/or prolonged colonic motor response to eating. This is believed to be the cause of their postprandial complaints. Since the flux of calcium ions across cell membranes plays a major role in the contractions of the gastrointestinal smooth muscle, we investigated the effect of nifedipine, a calcium channel blocker, on the gastrocolonic response in nine patients with the irritable colon syndrome. Colonic myoelectric and contractile activity was recorded during fasting and after a 1000-cal mixed meal, either with or without nifedipine (20 mg sublingually) administration. Nifedipine reduced the postprandial increase of both spike potential activity and motility index. This effect of acute administration of the drug provides rational support to test nifedipine in clinical trials as a possible means for treating the irritable colon syndrome. 相似文献