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61.
Firass Abiad Dalia Khalife Bassem Safadi Ramzi Alami Johnny Awwad Fatin Khalifeh Ghina Ghazeeri 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):999-1005
Aim
The aims of this study is to address the improvement in CRP and adiponectin in obese PCOS and non PCOS after bariatric surgery, and to show that obese PCOS women have a slower rate of improvement when compared to obese non PCOS women.Methods
This is a prospective case-control study evaluating the effect of weight loss by sleeve gastrectomy among obese PCOS patients.Results
There was a 36.28% of weight loss among obese PCOS and 33.04% among the control group at 12 months. Both groups showed a significant increase in the adiponectin levels at 3, 6 and 12 months’ post-surgery. The rate of increase was higher in the obese non PCOS women (4.93?±?1.79–9.79?±?3.9) compared to obese PCOS women (5.05?±?1.98–7.25?±?0.21). The CRP levels decreased with weight loss after the surgery to reach statistical significance at 3 months in obese PCOS group (4.18?±?3.94, p?=?0.048).Conclusion
The degree of weight loss after surgery was effective in lowering CRP and increasing adiponectin levels in PCOS women. However, this improvement was slower compared to obese non PCOS patients. A genetic predisposition to insulin resistance might explain these findings. 相似文献62.
Degos V Lescot T Icke C Le Manach Y Fero K Sanchez P Hadiji B Zouaoui A Boch AL Abdennour L Apfel CC Puybasset L 《Anesthesia and analgesia》2012,114(5):1026-1033
63.
Shankar R. Raman Dovid Moradi Bassem M. Samaan Umar S. Chaudhry Kamal Nagpal John Morgan Cosgrove Daniel T. Farkas 《Surgical endoscopy》2012,26(11):3174-3179
Background
Laparoscopic cholecystectomy is the gold-standard procedure for management of symptomatic gallstone disease. Increased rates of conversion to an open procedure, increased postoperative complications, and longer lengths of stay are seen in thick-walled gallbladders. Previous studies have only evaluated gallbladder walls as being thick or not thick, without looking at the degree of thickness. We hypothesized that, the more severe the wall thickening, the greater the chance of conversions and complications, and the longer the lengths of stay.Methods
All attempted laparoscopic cholecystectomies in our institution between 2006 and 2009 were retrospectively reviewed. Patients undergoing cholecystectomy for reasons other than gallstones (e.g., polyps or cancer) and those without preoperative ultrasounds were excluded. Patients were divided into four groups based on the degree of gallbladder wall thickness: normal (1–2?mm), mildly thickened (3–4?mm), moderately thickened (5–6?mm), and severely thickened (7?mm and above). Outcomes were compared amongst the groups.Results
874 patients were included in the study. There were 68 conversions (7.8?%) and 58 complications (6.6?%). The incidence of conversions was 3.1, 5.1, 14.9, and 16.8?% in the four groups, respectively (p?<?0.001, χ 2), and the incidence of complications was 1.8, 6.7, 9.1, and 13.1?%, respectively (p?=?0.001, χ 2). The mean (±?standard deviation, SD) length of stay in days was 1.09?±?1.42, 1.83?±?3.24, 2.54?±?3.40 and 3.54?±?4.61, respectively [p?<?0.001, analysis of variance (ANOVA)].Conclusions
A greater degree of gallbladder wall thickness is associated with an increased risk of conversion, increased postoperative complications, and longer lengths of stay. Classifying patients according to degree of gallbladder wall thickness gives more accurate assessment of the risk of surgery, as well as potential outcomes. 相似文献64.
65.
Procarbazine hydrochloride is an oral alkylating agent with activity against lymphoma. It is most commonly used in the treatment of Hodgkin's disease. The use of procarbazine-containing chemotherapeutic regimens in non-Hodgkin's lymphoma fell out of favor with the advent of CHOP. We report two patients with relapsed and/or refractory follicular lymphoma that achieved a complete and durable remission with a prolonged course of daily procarbazine. 相似文献
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69.
Felt SA Wasfy MO El-Tras WF Samir A Rahaman BA Boshra M Parker TM Hatem ME El-Bassiouny AA Murray CK Pimentel G 《The American journal of tropical medicine and hygiene》2011,84(3):420-425
A survey of 179 animals (black rats, dogs, sheep, buffaloes, cattle, donkeys, weasels, and cats) for Leptospira infection was conducted in Mahalla City (Lower Egypt). Blood, urine, and kidney were collected and tested by culture, microscopic agglutination test (MAT), and/or polymerase chain reaction (PCR). Among rats, 26% were positive by PCR, including 7% that were also positive by culture for L. interrogans serovars Grippotyphosa, Pyrogenes, and Icterohaemorrhagiae. L. borpetersenii serovar Polonica was isolated for the first time in Egypt in three rats. MAT titers ≥ 1:800 were observed in 11% of rats and 12% of dogs. L. interrogans serovar Grippotyphosa was detected in one cat. Sheep and donkeys were negative for leptospirosis by all methods. Buffaloes and cattle were seropositive in 20% and 44% of animals, respectively. Data indicate that several pathogenic serovars are circulating in the animals, which may pose exposure risks and account for high rates of acute febrile illness. 相似文献
70.
Tourdias T Hiba B Raffard G Biran M Nishiguchi T Aussudre J Franconi JM Brochet B Petry KG Dousset V 《Experimental neurology》2011,230(2):248-257
We aimed to determine an optimal protocol for inducing a focal inflammatory lesion within the rat brain that could be large enough for an easier MRI monitoring while still relevant as a multiple sclerosis (MS) like lesion. We adapted a two-hit model based on pre-sensitization of the Lewis rat with myelin oligodendrocyte protein (MOG) followed by stereotaxic injection of pro-inflammatory cytokines (TNFα + IFNγ) within the internal capsule. We compared the following two strategies to increase focal lesion development for an easier MR translation: (1) a higher sensitization step (MOG50) or (2) a higher cytokine step with lower sensitization (MOG25). Control animals were administered only cytokines without MOG pre-sensitization. Animals were followed with T2, diffusion and T1 post gadolinium weighted images at 1, 3 and 7 days following cytokine injection. Immunostaining was performed at the same time points for macrophages (ED1), myelin (MBP and Luxol Fast Blue) and blood brain barrier integrity (IgG). At day 1, the focal lesions depicted with T2-weighted images were very similar among groups and related to vasogenic edema (high apparent diffusion coefficient (ADC), gadolinium enhancement and IgG extravasation) induced by cytokines irrespective of the pre-sensitization step. Then, at day 3, MOG50 rats developed statistically larger T2 lesions than MOG25 and control rats that were correlated with inflammatory cell accumulation. At day 7, MOG50 rats also showed larger T2 lesions than MOG25 and control rats, together with loss of anisotropy that were correlated with demyelination. In contrast, MOG25 and control rats developed similar MR lesions decreasing over time and almost undetectable at day 7. We conclude that with a high pre-sensitization step, the focal lesion can be monitored by MRI whose signal reflects some features of a MS-like lesion, i.e. edema, inflammatory cell accumulation and later demyelination. 相似文献