全文获取类型
收费全文 | 2817篇 |
免费 | 190篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 97篇 |
妇产科学 | 51篇 |
基础医学 | 456篇 |
口腔科学 | 37篇 |
临床医学 | 248篇 |
内科学 | 463篇 |
皮肤病学 | 91篇 |
神经病学 | 270篇 |
特种医学 | 97篇 |
外科学 | 369篇 |
综合类 | 97篇 |
预防医学 | 166篇 |
眼科学 | 117篇 |
药学 | 241篇 |
中国医学 | 18篇 |
肿瘤学 | 173篇 |
出版年
2023年 | 20篇 |
2022年 | 34篇 |
2021年 | 78篇 |
2020年 | 30篇 |
2019年 | 69篇 |
2018年 | 81篇 |
2017年 | 47篇 |
2016年 | 70篇 |
2015年 | 71篇 |
2014年 | 79篇 |
2013年 | 114篇 |
2012年 | 163篇 |
2011年 | 194篇 |
2010年 | 125篇 |
2009年 | 71篇 |
2008年 | 142篇 |
2007年 | 129篇 |
2006年 | 131篇 |
2005年 | 106篇 |
2004年 | 100篇 |
2003年 | 80篇 |
2002年 | 84篇 |
2001年 | 60篇 |
2000年 | 83篇 |
1999年 | 70篇 |
1998年 | 22篇 |
1996年 | 13篇 |
1995年 | 19篇 |
1994年 | 16篇 |
1992年 | 39篇 |
1991年 | 38篇 |
1990年 | 44篇 |
1989年 | 45篇 |
1988年 | 32篇 |
1987年 | 40篇 |
1986年 | 37篇 |
1985年 | 37篇 |
1984年 | 31篇 |
1983年 | 27篇 |
1982年 | 18篇 |
1981年 | 17篇 |
1980年 | 25篇 |
1979年 | 30篇 |
1978年 | 15篇 |
1977年 | 20篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1974年 | 10篇 |
1973年 | 14篇 |
1969年 | 11篇 |
排序方式: 共有3021条查询结果,搜索用时 31 毫秒
51.
Manasi Banerjee Kuntal Bhattacharyya Rathindra Nath Sarkar Balaram Ghosh 《Indian Journal of Rheumatology》2012,7(3):135-140
BackgroundMechanical low back pain (MLBP) is a commonly encountered entity in clinical practice. Pain relief and restoration of functional capacity are management goals.Aims and objectivesTo compare the efficacy and tolerability of flupirtine, a selective neuronal potassium channel-opener (SNEPCO), with tramadol, a widely-used opioid analgesic, in MLBP.MethodsThis randomized, single-blinded, intention to treat (ITT) trial started with 240 non-steroidal anti-inflammatory drug (NSAID) intolerant patients who were prescribed either tablet flupirtine (100 mg twice daily) or capsule tramadol (50 mg twice daily), for 4 weeks. Follow-up was done on days 14, 28 and 4 weeks after treatment completion. Assessment of improvements in Indian Health Assessment Questionnaire Disability Index (Indian HAQ-DI), Visual Analogue Scale (VAS), Numerical Rating Scale (NRS) and measurement of Pain Relief Rate (PRR) were performed. Adverse events were recorded.ResultsOne hundred and seven patients receiving flupirtine and 103 receiving tramadol were analyzed on an ITT basis. Scores in Indian HAQ-DI, VAS and NRS improved significantly in both groups in the last visit, but more so with flupirtine. PRR was reasonably higher with flupirtine, [59 (55.14%)] patients experiencing significant to complete pain relief at the end of the study, compared to tramadol [41 (39.81%)]. Adverse effects were less with flupirtine [26 (24.30%) versus 41 (39.81%), p < 0.05], minimizing drop-outs.ConclusionFlupirtine has better sustained efficacy and tolerability than tramadol in MLBP. 相似文献
52.
Clarissa Campolina De Sá Mattosinho Anna Tereza M.S. Moura Gabriela Oigman Sima E. Ferman Nathália Grigorovski 《Pediatric hematology and oncology》2019,36(2):55-72
Retinoblastoma (RB) is the most common intraocular tumor of childhood. In low income countries, Time to diagnosis (TTD: interval between first symptom and diagnosis) has been associated with extraocular disease, metastasis and mortality. However, the relationship between TTD and prognosis is complex and not simply a linear correlation, particularly if TTD is <6?months. This systematic review aims to identify studies reporting TTD of retinoblastoma in Latin America, highlighting factors affecting TTD, alongside proposals and initiatives to obtain shorter intervals. The review also aims to discuss the methodology linked to cancer pathways studies. The study respected PRISMA recommendations, was registered on Prospero, an international database for systematic review registries under number CRD42017076777. MEDLINE/PUBMED, LILACS and SCIELO databases were searched. Studies from Latin America and the Caribbean, published between 1997 and 2017, reporting TTD and age at diagnosis of patients with retinoblastoma were selected. Nine studies were selected, concerning 1560 patients from Argentina, Brazil, Chile, Honduras, Mexico and Peru. The median TTD ranged from 3 to 5?months and the median age at diagnosis ranged from 16.5 to 22.2?months. A prolonged TTD was observed and was associated to damaging results on retinoblastoma outcomes, particularly increasing extraocular disease, and mortality rates. Methodological heterogeneity was observed and reiterates the importance of standardization of TTD studies, allowing more reliable comparisons and greater knowledge about retinoblastoma pathways before diagnosis. Reports on successful initiatives against delayed diagnosis were scarce, emphasizing a need for further studies. 相似文献
53.
Biswa Nath Sharma Manfred Marschall Stian Henriksen Christine Hanssen Rinaldo 《Antimicrobial agents and chemotherapy》2014,58(1):279-289
Polyomavirus BK (BKV) causes polyomavirus-associated nephropathy (PyVAN) and hemorrhagic cystitis (PyVHC) in renal and bone marrow transplant patients, respectively. Antiviral drugs with targeted activity against BKV are lacking. Since the antimalarial drug artesunate was recently demonstrated to have antiviral activity, the possible effects of artesunate on BKV replication in human primary renal proximal tubular epithelial cells (RPTECs), the host cells in PyVAN, were explored. At 2 h postinfection (hpi), RPTECs were treated with artesunate at concentrations ranging from 0.3 to 80 μM. After one viral replication cycle (approximately 72 hpi), the loads of extracellular BKV DNA, reflecting viral progeny production, were reduced in a concentration-dependent manner. Artesunate at 10 μM reduced the extracellular BKV load by 65%; early large T antigen mRNA and protein expression by 30% and 75%, respectively; DNA replication by 73%; and late VP1 mRNA and protein expression by 47% and 64%, respectively. Importantly, the proliferation of RPTECs was also inhibited in a concentration-dependent manner. At 72 hpi, artesunate at 10 μM reduced cellular DNA replication by 68% and total metabolic activity by 47%. Cell impedance and lactate dehydrogenase measurements indicated a cytostatic but not a cytotoxic mechanism. Flow cytometry and 5-ethynyl-2′-deoxyuridine incorporation revealed a decreased number of cells in S phase and suggested cell cycle arrest in G0 or G2 phase. Both the antiproliferative and antiviral effects of artesunate at 10 μM were reversible. Thus, artesunate inhibits BKV replication in RPTECs in a concentration-dependent manner by inhibiting BKV gene expression and genome replication. The antiviral mechanism appears to be closely connected to cytostatic effects on the host cell, underscoring the dependence of BKV on host cell proliferative functions. 相似文献
54.
Amy Henderson Riley Suruchi Sood Paramita Dasgupta Mazumdar Narendra Nath Choudary Alka Malhotra Naysan Sahba 《Journal of health communication》2017,22(1):66-74
Entertainment-education is an effective health communication strategy that combines or embeds educational messages into entertainment programs to bring about social and behavior change. For years, scholars have considered how entertainment-education works. Some contemporary theories posit that entertainment-education does not engender behavior change directly but does so through mediating variables. This study adds to the literature on this topic by exploring the direct relationship between exposure and social norms instead of their relationship through behavior as a mediator. Novel to this study is the use of encoded exposure, a continuous and recognition-based measure of exposure that includes ever watching, recall, involvement, and dose in its operationalization. Using cross-sectional data from Kyunki … Jeena Issi Ka Naam Hai, an entertainment-education program in India, this exploratory analysis indicates a positive and significant relationship between encoded exposure and social norms. How can this finding be applied to future programs? Questions remain, and replication is needed, but if it is not essential to go through behavior in order to change social norms, then implications emerge for the theory and practice of entertainment-education. 相似文献
55.
Arnab Bhattacharya Shyamanta Das Kamal Nath Dipak Dutta Sahoo Saddichha 《Annals of Indian Academy of Neurology》2012,15(2):161-162
Tuberous Sclerosis (TSC) is clinically marked by a triad of adenoma sebaceum, epilepsy and mental retardation. It can however manifest as various neuropsychiatric disorders. We report a patient who presented with TSC and co-morbid Obsessive Compulsive Disorder. 相似文献
56.
Compound muscle action potential (CMAP) amplitude declines during a paralytic attack in patients with hypokalemic periodic paralysis (HPP). However, serial motor nerve conduction studies in hypokalemic paralysis have not been commonly reported. We report two cases with hypokalemic paralysis, who had severely reduced CMAPs in all motor nerves at presentation during the episode of quadriparesis. However, the amplitude of CMAPs increased and reached normal levels, as the serum potassium concentration and motor power returned to normal state. 相似文献
57.
58.
Sripad V. Khairnar Ranjit Kumar Nath Balram Yadav Kakasaheb Bhosale Sulabh Chandraker 《Indian heart journal》2021,73(1):44-48
ObjectiveThe study aimed at to find out prevalence of abnormal upper limb arterial anatomy and its correlation with access failure during transradial coronary angiography.MethodThis was a prospective observational study of 1512 patients who had undergone transradial coronary angiography (CAG). Angiographic assessment of upper limb arterial tree was performed when the angiographic guidewire or the diagnostic catheter followed an abnormal path or got stuck in its course.ResultsAbout 5.29% patients (80/1512) were noted to have abnormal upper limb arterial anatomy. The most common abnormality detected were radio-ulnar loop in 22 (1.46%) patients, tortuous upper limb arteries 19 (1.25%) and abnormal high origin of radial artery 10 (0.66%) patients. Access failure was encountered in 4.4% (67/1512) of total patients and 64.17% (43/67) access failure was due to abnormal upper limb arterial anatomy.ConclusionAbnormal upper limb arterial anatomy was the most common cause of access failure in transradial coronary angiography in this study. 相似文献
59.
Effects of cyclosporine on the renin-angiotensin-aldosterone system and potassium excretion in renal transplant recipients 总被引:2,自引:0,他引:2
J P Bantle K A Nath D E Sutherland J S Najarian T F Ferris 《Archives of internal medicine》1985,145(3):505-508
To evaluate the mechanism of cyclosporine-induced hyperkalemia, the renin-angiotensin-aldosterone system and renal potassium clearance were compared in ten renal transplant recipients treated with cyclosporine and treated with azathioprine. After stimulation by a low-sodium diet and furosemide, cyclosporine-treated patients demonstrated lower plasma renin activity when supine (1.9 +/- 0.3 v 7.8 +/- 1.4 ng/mL/hr) and after standing (3.0 +/- 0.7 v 12.2 +/- 1.5 ng/mL/hr). Supine plasma aldosterone levels tended to be lower in cyclosporine-treated patients, (4.8 +/- v 10.5 +/- 2.6 ng/dL), although standing plasma aldosterone levels were not different (10.8 +/- 3.0 v 12.3 +/- 2.0 ng/dL). After administration of 0.75 mEq of potassium chloride per kilogram of body weight, cyclosporine-treated patients excreted 52% +/- 7.1% of the potassium load in six hours compared with excretion of 67% +/- 7.0% by the azathioprine-treated patients, although there was no difference in plasma aldosterone levels in response to the potassium load in the two groups. These data suggest that cyclosporine causes suppression of plasma renin activity and a tubular insensitivity to aldosterone, both of which may impair potassium excretion. 相似文献
60.
Latika Nath Prabhdeep Kaur Saurabh Tripathi 《Indian Journal of Community Medicine》2015,40(4):239-245