Heterologous Antilymphocyte Serum Hastens the Growth of 7,12-Dimethylbenz(��)Anthracene Induced Tumours in Mice

The present paper describes the effects of repeated administration of rabbit anti-mouse lymphocyte serum (ALS) or normal rabbit serum (NRS) on tumours induced in Charles-River mice by 7,12-dimethylbenz(α)anthracene (DMBA) given at birth. ALS or NRS were given either at the time of DMBA administration and subsequently at weekly intervals for the first 10 weeks of life, or at daily intervals for 7 days during the first, second, third or fourth week of life. The incidence and histology of the tumours were studied. It was found that treatment of very young mice with ALS greatly reduced the mean survival time of mice and significantly increased the incidence of malignant lymphoma. The incidence of lung tumours was found to be significantly increased in the animals injected with ALS during the second week of life.     

Retroperitoneoscopy for biopsy of pelvic and medium-low para-aortic lymph nodes and tissues

A mediastinoscope is used for pelvic, low and medium retroperitoneoscopy. Twelve procedures have been performed in 11 selected patients. The method is proposed for diagnosis and staging of lymphomas, genitourinary tumors and other miscellaneous pathology of the retroperitoneum.     

Dynamic CT evaluation of the central airways in patients undergoing tracheoplasty for tracheobronchomalacia

OBJECTIVE: The objective of this study was to describe the role of pre- and postoperative dynamic CT in patients undergoing tracheoplasty, a novel surgical method for treatment of severely symptomatic tracheobronchomalacia. CONCLUSION: Five patients were referred for dynamic MDCT before and after undergoing tracheoplasty at our institution. Preoperatively, all patients showed signs of tracheobronchomalacia (> or = 50% airway collapse) on bronchoscopy, and four (80%) of these five patients showed evidence of malacia on dynamic forceful expiratory CT scans. In all five cases, postoperative CT showed a reduction in the degree of airway collapse during expiration, changes in shape of the trachea during inspiration, and posterior wall thickening related to the procedure. Our preliminary results suggest a potentially important role for CT in the pre- and postoperative assessments of patients with tracheobronchomalacia referred for tracheoplasty.