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Tarcisio Vieira de Brito Rafael da Silva Prudêncio Adriano Bezerra Sales Francisco das Chagas Vieira Júnior Starley Jone Nogueira Candeira Álvaro Xavier Franco Karoline Sabóia Aragão Ronaldo de Albuquerque Ribeiro Marcellus Henrique Loiola Ponte de Souza Luciano de Sousa Chaves Ana Lúcia Ponte Freitas Jand‐Venes Rolim Medeiros André Luiz dos Reis Barbosa 《The Journal of pharmacy and pharmacology》2013,65(5):724-733
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Helena Lutéscia L. Coelho Luís Carlos Rey Marina S.G. de Medeiros Ronaldo A. Barbosa Said G. da Cruz Fonseca Patricia Q. da Costa 《Jornal de pediatria》2013,89(2):171-178
ObjectiveTo perform a critical comparison between the Brazilian national essential medicines list (Rename, 2012) with the list of essential medicines for children (LEMC, 2011) of the World Health Organization (WHO), regarding the differences among drugs and formulations listed for children.MethodsThe LEMC drugs were classified into four categories: 1) absent in Rename; 2) included in Rename but without any formulation suitable for children; 3) listed in Rename only in some formulations; 4) present in Rename in all formulations. The missing formulations were analyzed by therapeutic group. Alternatives present in Rename were searched.ResultsFrom the 261 drugs of interest on the LEMC, 30.3% are absent from Rename, 11.1% are in Rename but without any pediatric formulation, and 32.2% are present in some but not all formulations listed in LEMC. Considering all formulations items listed in the LEMC (n = 577), 349 are missing from Rename, of these 19.6% due to their strength, and 18.5% due to the the dosage form. Useful formulations specific for neonatal care, respiratory tract, central nervous system, and anti-infectives, among other groups, are missing.ConclusionThe lack of age-appropriate formulations of essential medicines for children in Brazil includes important therapeutic groups and indispensable drugs for severe clinical conditions. Some of these products exist in the Brazilian pharmaceutical market, but not in public facilities; others could be produced by national laboratories with commercial interest or stimulated by a specific governmental policy, as in other countries. 相似文献
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Camila Padilha Barbosa Juliana Barbosa Aires Isabela Yasmin dos Santos Farias Francisca Márcia Pereira Linhares Silvana Maria Sobral Griz 《Revista brasileira de otorrinolaringologia (English ed.)》2013,79(2):226-232
Hearing loss is a sensory deprivation, which can brings several consequences, among them: language development delay, emotional and social problems, and school difficulties. In such settings, we stress the role of nursing professional, who can expand their knowledge about children's hearing health, all the way from pre-natal care.ObjectiveTo check the knowledge of nursing professional after the educational actions on pediatric hearing.MethodA quasi-experimental design with time-series outline. We had 82 nursing professional participating (nurses, technicians and assistants) working in a university hospital between March and September of 2011. All of the interviewees answered a semi-structured questionnaire before and after the educational actions.ResultsWe observed a significant change in the knowledge of the nursing professionals after the educational activity in most of the variables; such as: ideal age to perform the newborn hearing screening; ideal age to diagnose hearing loss; ideal age to start intervention against hearing loss and risk indicators for hearing loss.ConclusionIt is believed that the methodology used in educational activities, based on problems found in professional practice, education may have contributed greatly to increase knowledge about hearing health, especially concerning neonates and infants. 相似文献
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J.S.M. Alves J.H. Leal-Cardoso F.F.U. Santos-Júnior P.S. Carlos R.C. Silva C.M. Lucci S.N. Báo V.M. Ceccatto R. Barbosa 《Brazilian journal of medical and biological research》2013,46(8):715-721
Immobilization, used in clinical practice to treat traumatologic problems, causes
changes in muscle, but it is not known whether changes also occur in nerves. We
investigated the effects of immobilization on excitability and compound action
potential (CAP) and the ultrastructure of the rat sciatic nerve. Fourteen days after
immobilization of the right leg of adult male Wistar rats (n=34), animals were killed
and the right sciatic nerve was dissected and mounted in a moist chamber. Nerves were
stimulated at a baseline frequency of 0.2 Hz and tested for 2 min at 20, 50, and 100
Hz. Immobilization altered nerve excitability. Rheobase and chronaxy changed from
3.13±0.05 V and 52.31±1.95 µs (control group, n=13) to 2.84±0.06 V and 59.71±2.79 µs
(immobilized group, n=15), respectively. Immobilization altered the amplitude of CAP
waves and decreased the conduction velocity of the first CAP wave (from 93.63±7.49 to
79.14±5.59 m/s) but not of the second wave. Transmission electron microscopy showed
fragmentation of the myelin sheath of the sciatic nerve of immobilized limbs and
degeneration of the axon. In conclusion, we demonstrated that long-lasting leg
immobilization can induce alterations in nerve function. 相似文献
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